Morphology and distribution of chandelier cell axon terminals in the mouse cerebral cortex and claustroamygdaloid complex

Inda, M. C.; DeFelipe, J.; Munoz, A.

doi:10.1093/cercor/bhn057

Cited by 52Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Morphology and distribution of chandelier cell axon terminals in the mouse cerebral cortex and claustroamygdaloid complex

Inda, M. C., DeFelipe, J., Munoz, A.·2009·Cerebral Cortex

DOI 10.1093/cercor/bhn057

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Abstract

Chandelier cells represent a unique type of cortical gamma-aminobutityric acidergic interneuron whose axon terminals (Ch-terminals) only form synapses with the axon initial segments of some pyramidal cells. Here, we have used immunocytochemistry for the high-affinity plasma membrane transporter GAT-1 and the calcium-binding protein parvalbumin to analyze the morphology and distribution of Ch-terminals in the mouse cerebral cortex and claustroamygdaloid complex. In general, 2 types of Ch-terminals were distinguished on the basis of their size and the density of the axonal boutons that made up the terminal. Simple Ch-terminals were made up of 1 or 2 rows of labeled boutons, each row consisting of only 3-5 boutons. In contrast, complex Ch-terminals were tight cylinder-like structures made up of multiple rows of boutons. Simple Ch-terminals were detected throughout the cerebral cortex and claustroamygdaloid complex, the complex type was only occasionally found in certain regions, whereas in others they were very abundant. These results indicate that there are substantial differences in the morphology and distribution of Ch-terminals between different areas and layers of the mouse cerebral cortex. Furthermore, we suggest that the distribution of complex Ch-terminals may be related to the developmental origin of the different brain regions analyzed.

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Chandelier cells are particularly abundant at the border between layers 1 and 2 and in layer 6, and their regional distribution is very heterogeneous.
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Authors: Inda, M. C., DeFelipe, J., & Munoz, A.
Affiliations: Universidad Complutense de Madrid (ES)
Consejo Superior de Investigaciones Científicas (ES)
ORCID: DeFelipe, J.
Venue: Cerebral Cortex
Publisher: Oxford University Press (OUP)
Published: 2008-04-24
Volume: 19
Issue: 1
Pages: 41-54
ISSN: 1047-3211 (ISSN-L)
1460-2199
DOI: 10.1093/cercor/bhn057
OpenAlex: W2150824195
Cited by: 51
References: 89
Citations by year: 2023: 3 · 2022: 7 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 9 · 2013: 3 · 2012: 3
FWCI: 1.59
Type: journal article
Language: en
Open access: closed
Locations: Cerebral Cortex (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: chandelier cells, axon terminals, GABAergic interneurons, axon initial segment, pyramidal neurons, GABA transporter 1, parvalbumin, axonal boutons, cortical layers, brain development, mice
MeSH terms: Amygdala, Animals, Axons, Cerebral Cortex, Female, Male, Mice, Inbred C57BL, Neural Pathways, Mice

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Morphology and distribution of chandelier cell axon terminals in the mouse cerebral cortex and claustroamygdaloid complex

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