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Cited by 19Neural and Behavioral Psychology StudiesNeural dynamics and brain functionMemory and Neural Mechanisms

Neuronal responses to a delayed-response delayed-reward go/nogo task in the monkey posterior insular cortex

Asahi, T., Uwano, T., Eifuku, S., Tamura, R., Endo, S., Ono, T., Nishijo, H.·2006·Neuroscience
DOI 10.1016/j.neuroscience.2006.08.008
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Abstract

Anatomical connections of the insular cortex suggest its involvement in cognition, emotion, memory, and behavioral manifestation. However, there have been few neurophysiological studies on the insular cortex in primates, in relation to such higher cognitive functions. In the present study, neural activity was recorded from the monkey insular cortex during performance of a delayed-response delayed-reward go/nogo task. In this task, visual stimuli indicating go or nogo responses associated with reward (reward trials) and with no reward (no-reward trials) were presented after eye fixation. In the reward trials, the monkey was required to release a button during presentation of the 2nd visual stimuli after a delay period (delay 1). Then, a juice reward was delivered after another delay (delay 2). The results indicated that the neurons responding in each epoch of the task were topographically localized within the insular cortex, consistent with the previous anatomical studies indicating topographical distributions of afferent inputs from other subcortical and cortical sensory areas. Furthermore, some insular neurons 1) nonspecifically responded to the visual cues and during fixation; 2) responded to the visual cues predicting reward and during the delay period before reward delivery; 3) responded differentially in go/nogo trials during the delay 2; and 4) responded around button manipulation. The observed patterns of insular-neuron responses and the correspondence of their topographical localization to those in previous anatomical studies suggest that the insular cortex is involved in attention- and reward-related functions and might monitor and integrate activities of other brain regions during cognition and behavioral manifestation.

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  • Activity in areas subserving interoception, including the insula and ACC, shows patterns consistent with the representation of risk and risk and reward prediction errors.

    “Studies using this technique have demonstrated that activity in areas subserving interoception, including the insula and ACC, show patterns of activity consistent with the representation of risk (formally the variance associated with the outcome of a particular stimulus) and risk and reward prediction errors (Asahi et al., 2006; Mizuhiki et al., 2012; Paulus, Rogalsky, et al., 2003; Preuschoff et”

    From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Asahi et al., 2006

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Authors
Asahi, T., Uwano, T., Eifuku, S., Tamura, R., Endo, S., Ono, T., & Nishijo, H.
Affiliations
University of Toyama (JP)
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2006-12
Volume
143
Issue
2
Pages
627-639
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2006.08.008
OpenAlex
W2292173616
Cited by
19
References
70
Citations by year
2026: 1 · 2025: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 2 · 2012: 2
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
posterior insular cortex, go/no-go task, delayed response, delayed rewards, neural responses, topographic localization, reward prediction, attention, cognitive control, afferent connections, delay period
MeSH terms
Analysis of Variance, Animals, Behavior, Animal, Brain Mapping, Cerebral Cortex, Choice Behavior, Electromyography, Macaca mulatta, Neurons, Reaction Time, Reward

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