Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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Anticancer activities of histone deacetylase inhibitors

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Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

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Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

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Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of Action

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Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

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Microglial activation correlates with severity in Huntington disease: A clinical and PET study

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Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease

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Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

Ren, M., Leng, Y., Jeong, M. R., Leeds, P. R., & Chuang, D. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02406.x · Cited by 375

Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes

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Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation

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Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.

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Regulation of microglial inflammatory response by sodium butyrate and short‐chain fatty acids

Huuskonen, J., Suuronen, T., Nuutinen, T., Kyrylenko, S., & Salminen, A. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705682 · Cited by 281

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

Minamiyama, M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh131 · Cited by 260

Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases?

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Endogenous α-Synuclein Is Induced by Valproic Acid through Histone Deacetylase Inhibition and Participates in Neuroprotection against Glutamate-Induced Excitotoxicity

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Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia

Peng, G.-S., Li, G., Tzeng, N., Chen, P.-S., Chuang, D., Hsu, Y., Yang, S., & Hong, J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.10.021 · Cited by 169

Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis

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The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

Moreira, J. M. A., Scheipers, P., & Sørensen, P. (2003) · BMC Cancer · doi:10.1186/1471-2407-3-30 · Cited by 143

Microglial Phagocytosis of Apoptotic Inflammatory T Cells Leads to Down-Regulation of Microglial Immune Activation

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Downregulation of lipopolysaccharide response in drosophila by negative crosstalk between the AP1 and NF-κB signaling modules

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Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition

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Valproic acid inhibits histone deacetylase activity and suppresses excitotoxicity-induced GAPDH nuclear accumulation and apoptotic death in neurons

Kanai, H., Sawa, A., Chen, R.-W., Leeds, P. R., & Chuang, D. M. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500269 · Cited by 124

Linear Relationship of Valproate Serum Concentration to Response and Optimal Serum Levels for Acute Mania

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Regulation of microglial inflammatory response by histone deacetylase inhibitors

Suuronen, T., Huuskonen, J., Pihlaja, R., Kyrylenko, S., & Salminen, A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02004.x · Cited by 123

Neuroprotective Activities of Sodium Valproate in a Murine Model of Human Immunodeficiency Virus-1 Encephalitis

Dou, H., Birusingh, K., Faraci, J., Gorantla, S., Poluektova, L. Y., Maggirwar, S. B., Dewhurst, S., Gelbard, H. A., & Gendelman, H. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09162.2003 · Cited by 120

Phagocytosis of Apoptotic Cells by Macrophages Induces Novel Signaling Events Leading to Cytokine-Independent Survival and Inhibition of Proliferation: Activation of Akt and Inhibition of Extracellular Signal-Regulated Kinases 1 and 2

Reddy, S. M., Hsiao, K.-C., Abernethy, V. E., Fan, H., Longacre, A., Lieberthal, W., Rauch, J., Koh, J. S., & Levine, J. S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.702 · Cited by 110

Neuroprotective Effects of Phenylbutyrate Against MPTP Neurotoxicity

Gárdián, G., Yang, L., Cléren, C., Calingasan, N. Y., Klivènyi, P., & Beal, M. F. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:3:235 · Cited by 107

T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients.

Kim, Y.-K., Myint, A.-M., Lee, B.-H., Han, C.-S., Lee, S.-W., Leonard, B. E., & Steinbusch, H. W. M. (2004) · Psychiatry Research · doi:10.1016/j.psychres.2004.08.005 · Cited by 100

Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: Termination of CNS autoimmune inflammation and modulation by interferon‐beta

Chan, A., Seguin, R. M., Magnus, T., Papadimitriou, C., Toyka, K. V., Antel, J. P., & Gold, R. (2003) · Glia · doi:10.1002/glia.10258 · Cited by 74

Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia

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Valproic acid induces caspase 3-mediated apoptosis in microglial cells

Dragunow, M., Greenwood, J. M., Cameron, R. E., Narayan, P. J., O’Carroll, S. J., Pearson, A. G., & Gibbons, H. M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.065 · Cited by 67

New method to detect histone acetylation levels by flow cytometry

Ronzoni, S., Faretta, M., Ballarini, M., Pelicci, P. G., & Minucci, S. (2005) · Cytometry Part A · doi:10.1002/cyto.a.20151 · Cited by 66

CYP2E1-mediated modulation of valproic acid-induced hepatocytotoxicity

Neuman, M. G., Shear, N. H., Jacobson-Brown, P., Katz, G. G., Neilson, H. K., Malkiewicz, I. M., Cameron, R., & Abbott, F. S. (2001) · Clinical Biochemistry · doi:10.1016/s0009-9120(01)00217-x · Cited by 63

Repression of interferon-γ-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways

Park, J., Woo, M.-S., Kim, S. Y., Kim, W.-K., & Kim, H.-S. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.07.003 · Cited by 63

Actions of a Histone Deacetylase Inhibitor NSC3852 (5-Nitroso-8-quinolinol) Link Reactive Oxygen Species to Cell Differentiation and Apoptosis in MCF-7 Human Mammary Tumor Cells

Martirosyan, A., Leonard, S. S., Shi, X., Griffith, B. N., Gannett, P. M., & Strobl, J. S. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.096891 · Cited by 62

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells

Wiebe, J. P., & Lewis, M. J. (2003) · BMC Cancer · doi:10.1186/1471-2407-3-9 · Cited by 58

Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide-mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia

Kim, H.-S., Whang, S.-Y., Woo, M.-S., Park, J., Kim, W.-K., & Han, I. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.02.006 · Cited by 43

Microglial distribution and apoptosis in fetal rat brain

Wang, C.-C., Wu, C., Shieh, J.-Y., & Wen, C.-Y. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00584-9 · Cited by 23

Evidence for Epigenetic Mechanisms That Silence Both Basal and Immune-Stimulated Transcription of the IL-8 Gene

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Untitled work

Nolte (2001) · doi:10.1002/1098-1136(20010101)33:1

Regulation of inflammation by short chain fatty acids

Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724

Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

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The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis

Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891

Multiple roles of HDAC inhibition in neurodegenerative conditions

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The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

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Histone deacetylase inhibition leads to neuroprotection through regulation on glial function

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Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia

Singh, V., Bhatia, H. S., Kumar, A., de Oliveira, A. C. P., & Fiebich, B. L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.037 · Cited by 53

Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia

Peng, G.-S., Li, G., Tzeng, N., Chen, P.-S., Chuang, D., Hsu, Y., Yang, S., & Hong, J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.10.021 · Cited by 169

Valproic acid inhibits histone deacetylase activity and suppresses excitotoxicity-induced GAPDH nuclear accumulation and apoptotic death in neurons

Kanai, H., Sawa, A., Chen, R.-W., Leeds, P. R., & Chuang, D. M. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500269 · Cited by 124

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

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