Multiple roles of HDAC inhibition in neurodegenerative conditions

Chuang, De-Maw; Leng, Yan; Marinova, Zoya; Kim, Hyeon-Ju; Chiu, Chi-Tso

doi:10.1016/j.tins.2009.06.002

Cited by 676Histone Deacetylase Inhibitors ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Multiple roles of HDAC inhibition in neurodegenerative conditions

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Chuang, De-Maw, Leng, Yan, Marinova, Zoya, Kim, Hyeon-Ju, Chiu, Chi-Tso·2009·Trends in Neurosciences

DOI 10.1016/j.tins.2009.06.002PMC PMC2771446

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Abstract

Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histones and other proteins and in regulating fundamental cellular activities such as transcription. A wide range of brain disorders are associated with imbalances in protein acetylation levels and transcriptional dysfunctions. Treatment with various HDAC inhibitors can correct these deficiencies and has emerged as a promising new strategy for therapeutic intervention in neurodegenerative disease. Here, we review and discuss intriguing recent developments in the use of HDAC inhibitors to combat neurodegenerative conditions in cellular and disease models. HDAC inhibitors have neuroprotective, neurotrophic and anti-inflammatory properties; improvements in neurological performance, learning/memory and other disease phenotypes are frequently seen in these models. We discuss the targets and mechanisms underlying these effects of HDAC inhibition and comment on the potential for some HDAC inhibitors to prove clinically effective in the treatment of neurodegenerative disorders.

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HDAC inhibitors exert neuroprotective effects through anti-inflammatory mechanisms such as reduced microglial activation and through non-transcriptional actions including microtubule acetylation-mediated support of axonal transport and plasticity.
“HDAC inhibitors exert neuroprotective effects through both anti-inflammatory mechanisms, such as reduced microglial activation, and non-transcriptional actions, including microtubule acetylation–mediated support of axonal transport and plasticity (Glozak et al., 2005; Chuang et al., 2009; Suh et al., 2010).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Chuang et al., 2009
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Authors: Chuang, D.-M., Leng, Y., Marinova, Z., Kim, H.-J., & Chiu, C.-T.
Affiliations: National Institutes of Health (US)
Corresponding author: Chuang, De-Maw
ORCID: Leng, Yan
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2009-11
Volume: 32
Issue: 11
Pages: 591-601
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2009.06.002
PMC: PMC2771446
OpenAlex: W1964951942
Cited by: 676
References: 106
Citations by year: 2026: 22 · 2025: 33 · 2024: 40 · 2023: 38 · 2022: 29 · 2021: 39 · 2020: 36 · 2019: 30 · 2018: 34 · 2017: 45 · 2016: 46 · 2015: 40 · 2014: 55 · 2013: 62 · 2012: 44
FWCI: 3.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (Z01MH002468)
National Institute of Environmental Health Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: histone deacetylase, histone deacetylase inhibitors, neurodegenerative diseases, protein acetylation, transcriptional regulation, neuroprotection, neurotrophic effects, anti-inflammatory activity, learning and memory, disease models
MeSH terms: Acetylation, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Animals, Disease Models, Animal, Histone Deacetylases, Histones, Humans, Huntington Disease, Muscular Atrophy, Spinal, Parkinson Disease, Neuroprotective Agents, Neurodegenerative Diseases, Stroke, Rats, Histone Deacetylase Inhibitors

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