The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity
Open accessAbstract
Valproic acid (VPA), a widely prescribed drug for seizures and bipolar disorder, has been shown to be an inhibitor of histone deacetylase (HDAC). Our previous study has demonstrated that VPA pretreatment reduces lipopolysaccharide (LPS)-induced dopaminergic (DA) neurotoxicity through the inhibition of microglia over-activation. The aim of this study was to determine the mechanism underlying VPA-induced attenuation of microglia over-activation using rodent primary neuron/glia or enriched glia cultures. Other histone deacetylase inhibitors (HDACIs) were compared with VPA for their effects on microglial activity. We found that VPA induced apoptosis of microglia cells in a time- and concentration-dependent manner. VPA-treated microglial cells showed typical apoptotic hallmarks including phosphatidylserine externalization, chromatin condensation and DNA fragmentation. Further studies revealed that trichostatin A (TSA) and sodium butyrate (SB), two structurally dissimilar HDACIs, also induced microglial apoptosis. The apoptosis of microglia was accompanied by the disruption of mitochondrial membrane potential and the enhancement of acetylation levels of the histone H3 protein. Moreover, pretreatment with SB or TSA caused a robust decrease in LPS-induced pro-inflammatory responses and protected DA neurons from damage in mesencephalic neuron-glia cultures. Taken together, our results shed light on a novel mechanism whereby HDACIs induce neuroprotection and underscore the potential utility of HDACIs in preventing inflammation-related neurodegenerative disorders such as Parkinson's disease.
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“Indeed, treatment of microglial cells in vitro with various SCFAs, including valproic acid and butyric acid, elevates levels of acetylation of histone H3 (Chen et al., 2007).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Chen et al., 2007
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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
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Self-citationAnticancer activities of histone deacetylase inhibitors
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Microglial activation correlates with severity in Huntington disease: A clinical and PET study
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Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891
Multiple roles of HDAC inhibition in neurodegenerative conditions
Chuang, D.-M., Leng, Y., Marinova, Z., Kim, H.-J., & Chiu, C.-T. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.06.002 · Cited by 676
The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Réus, G. Z., Fries, G. R., Stertz, L., Badawy, M., Passos, I. C., Barichello, T., Kapczinski, F., & Quevedo, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.018 · Cited by 594
Metadata
- Authors
- Chen, P. S., Wang, C.-C., Bortner, C. D., Peng, G.-S., Wu, X., Pang, H., Lu, R.-B., Gean, P.-W., Chuang, D.-M., & Hong, J.-S.
- Affiliations
- National Institutes of Health (US)
- Tri-Service General Hospital (TW)
- National Cheng Kung University (TW)
- Corresponding author
- Hong, J.-S.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 149
- Issue
- 1
- Pages
- 203-212
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2741413
- OpenAlex
- W2039098916
- Cited by
- 262
- References
- 43
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 10 · 2023: 12 · 2022: 14 · 2021: 14 · 2020: 10 · 2019: 13 · 2018: 13 · 2017: 13 · 2016: 14 · 2015: 22 · 2014: 18 · 2013: 17 · 2012: 16
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences (Z01ES090082)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- valproic acid, histone deacetylase inhibitors, microglial apoptosis, lipopolysaccharide, dopaminergic neurotoxicity, trichostatin A, sodium butyrate, mitochondrial membrane potential, histone H3 acetylation, neuroinflammation, neuroprotection, Parkinson's disease, microglial activation
- MeSH terms
- Animals, Animals, Newborn, Brain, Cell Cycle, Cells, Cultured, Dopamine, Dose-Response Relationship, Drug, Enzyme Inhibitors, Female, Lipopolysaccharides, Neuroglia, Neurons, Nitrites, Pregnancy, Rats, Inbred F344, Tumor Necrosis Factor-alpha, Valproic Acid, Apoptosis, In Situ Nick-End Labeling, Rats, Histone Acetyltransferases, Membrane Potential, Mitochondrial
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