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Cited by 406Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionIon channel regulation and function

Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity

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Caillard, Olivier, Moreno, Herman, Schwaller, Beat, Llano, Isabel, Celio, Marco R., Marty, Alain·2000·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.230362997PMC PMC27231
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Abstract

GABAergic (GABA = γ-aminobutyric acid) neurons from different brain regions contain high levels of parvalbumin, both in their soma and in their neurites. Parvalbumin is a slow Ca 2+ buffer that may affect the amplitude and time course of intracellular Ca 2+ transients in terminals after an action potential, and hence may regulate short-term synaptic plasticity. To test this possibility, we have applied paired-pulse stimulations (with 30- to 300-ms intervals) at GABAergic synapses between interneurons and Purkinje cells, both in wild-type (PV+/+) mice and in parvalbumin knockout (PV−/−) mice. We observed paired-pulse depression in PV+/+ mice, but paired-pulse facilitation in PV−/− mice. In paired recordings of connected interneuron-Purkinje cells, dialysis of the presynaptic interneuron with the slow Ca 2+ buffer EGTA (1 mM) rescues paired-pulse depression in PV−/− mice. These data show that parvalbumin potently modulates short-term synaptic plasticity.

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  • ODP may be promoted by reducing parvalbumin-expressing interneuron activity in bV1.

    “ODP may be promoted by reducing parvalbumin-expressing (PVs) interneuron activity in bV1 (Caillard et al., 2000;Donato et al., 2013;Reh et al., 2020).”

    From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Caillard et al., 2000

    The Abstract and Results examine parvalbumin loss at cerebellar interneuron–Purkinje cell synapses and report changes in paired-pulse plasticity. Searches for ocular dominance plasticity, bV1, and reduced parvalbumin-expressing interneuron activity found no passage addressing whether that intervention promotes ODP. (LLM, conf=0.76)

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  • PV increases the rate of calcium sequestration, lowers presynaptic calcium levels, modulates short-term synaptic plasticity, and prevents cumulative facilitation.

    “PV increases the rate of Ca 2+ sequestration, reduces presynaptic Ca 2+ levels, modulates short-term synaptic plasticity, and prevents cumulative facilitation (Fig. 1), [67,68].”

    From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [67]

  • Absence of PV in PV-/- Pvalb neurons does not affect basal synaptic transmission but enhances facilitation and shortens delayed transmitter release.

    “The absence of PV in PV-/- Pvalb neurons does not affect basal synaptic transmission, but enhances facilitation [49, 50] and shortens delayed transmitter release [51].”

    From Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism (2016) · cites this paper as [49]

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Authors
Caillard, O., Moreno, H., Schwaller, B., Llano, I., Celio, M. R., & Marty, A.
Affiliations
Max Planck Institute for Biophysical Chemistry (DE)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2000-11-07
Volume
97
Issue
24
Pages
13372-13377
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.230362997
PMC
PMC27231
OpenAlex
W2059675111
Cited by
406
References
46
Citations by year
2026: 7 · 2025: 16 · 2024: 24 · 2023: 10 · 2022: 28 · 2021: 21 · 2020: 19 · 2019: 24 · 2018: 17 · 2017: 9 · 2016: 12 · 2015: 10 · 2014: 24 · 2013: 12 · 2012: 17
FWCI
4.00
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
parvalbumin, short-term plasticity, paired-pulse depression, paired-pulse facilitation, GABAergic interneurons, Purkinje cells, calcium buffering, calcium transients, EGTA, presynaptic terminals
MeSH terms
Animals, Cerebellum, Egtazic Acid, Electric Stimulation, Electrophysiology, Interneurons, Neuronal Plasticity, Parvalbumins, Purkinje Cells, Quinoxalines, Synapses, 2-Amino-5-phosphonovalerate, Mice, Knockout, Excitatory Amino Acid Antagonists, Mice, In Vitro Techniques

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