Cited by 107Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionPhytochemicals and Antioxidant Activities

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease

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Amato, Antonella, Terzo, Simona, Mulè, Flavia·2019·Antioxidants

Abstract

The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs. In particular, diets enriched with natural compounds have become an increasingly attractive, non-invasive, and inexpensive option to support a healthy brain and to potentially treat NDs. Bioactive compounds found in vegetables or microalgae possess special properties able to counteract oxidative stress, which is involved as a triggering factor in neurodegeneration. Here, we briefly review the relevant experimental data on curcuminoids, silymarin, chlorogenic acid, and compounds derived from the microalga Aphanizomenon flos aquae (AFA) which have been demonstrated to possess encouraging beneficial effects on neurodegeneration, in particular on Alzheimer’s disease models.

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  1. [1]Yacoubian T.A. Neurodegenerative disorders: Why do we need new therapies? Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders Adejare A. Academic Press London, UK 2017 1 16
  2. [58]Kamran A. Sadia S. A comprehensive review on Curcuma longa Linn.: Phytochemical, pharmacological, and molecular study IJGP 2017 11 S671

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Authors
Amato, A., Terzo, S., & Mulè, F.
Affiliations
University of Palermo (IT)
Corresponding author
Amato, Antonella
Venue
Antioxidants
Publisher
MDPI AG
Published
2019-11-30
Volume
8
Issue
12
Pages
608
ISSN
2076-3921 (ISSN-L)
OpenAlex
W2990286460
Cited by
107
References
140
Citations by year
2026: 9 · 2025: 7 · 2024: 15 · 2023: 21 · 2022: 21 · 2021: 26 · 2020: 7 · 2019: 1
FWCI
1.62
Type
journal article
Language
en
Open access
Locations
  • Antioxidants (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
natural compounds, neurodegenerative diseases, Alzheimer's disease, oxidative stress, dietary intervention, curcuminoids, silymarin, chlorogenic acid, Aphanizomenon flos-aquae, microalgae, neuroprotection

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