Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease
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The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs. In particular, diets enriched with natural compounds have become an increasingly attractive, non-invasive, and inexpensive option to support a healthy brain and to potentially treat NDs. Bioactive compounds found in vegetables or microalgae possess special properties able to counteract oxidative stress, which is involved as a triggering factor in neurodegeneration. Here, we briefly review the relevant experimental data on curcuminoids, silymarin, chlorogenic acid, and compounds derived from the microalga Aphanizomenon flos aquae (AFA) which have been demonstrated to possess encouraging beneficial effects on neurodegeneration, in particular on Alzheimer’s disease models.
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The fraction of phenolic compounds, consisting mainly of caffeic acid, quinic acid, and the chlorogenic acids family, is suggested to be the main compounds responsible for the antioxidant and anti-inflammatory properties of coffee ground extracts.
“It is suggested that the fraction of phenolic compounds, consisting mainly of caffeic acid (CA), quinic acid (QA), and the chlorogenic acids family, are the main compounds responsible for these properties [145,146,147,148,149,150,151].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [145]
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- Authors
- Amato, A., Terzo, S., & Mulè, F.
- Affiliations
- University of Palermo (IT)
- Corresponding author
- Amato, Antonella
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2019-11-30
- Volume
- 8
- Issue
- 12
- Pages
- 608
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC6943487
- OpenAlex
- W2990286460
- Cited by
- 107
- References
- 140
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 15 · 2023: 21 · 2022: 21 · 2021: 26 · 2020: 7 · 2019: 1
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- natural compounds, neurodegenerative diseases, Alzheimer's disease, oxidative stress, dietary intervention, curcuminoids, silymarin, chlorogenic acid, Aphanizomenon flos-aquae, microalgae, neuroprotection
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