Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity

Forecasting the global burden of Alzheimer's disease

Brookmeyer, R., Johnson, E., Ziegler‐Graham, K., & Arrighi, H. M. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.04.381 · Cited by 3,370 · see citing works

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975 · see citing works

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

Hanger, D. P., Anderton, B. H., & Noble, W. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.01.003 · Cited by 965 · see citing works

Tau protein kinases: Involvement in Alzheimer's disease

Martin, L., Latypova, X., Wilson, C. M., Magnaudeix, A., Perrin, M.-L., Yardin, C., & Terro, F. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.003 · Cited by 631 · see citing works

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

Wang, J., Grundke, I., & Iqbal, K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05226.x · Cited by 553 · see citing works

Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

Gong, C., Singh, T. J., Grundke‐Iqbal, I., & Iqbal, K. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03603.x · Cited by 527 · see citing works

Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslatica

Brinkhaus, B., Lindner, M., Schuppan, D., & Hahn, E. G. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80065-3 · Cited by 525 · see citing works

The molecular bases of Alzheimer’s disease and other neurodegenerative disorders

Maccioni, R. B., Muñoz, J. P., & Barbeito, L. (2001) · Archives of Medical Research · doi:10.1016/s0188-4409(01)00316-2 · Cited by 474 · see citing works

Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain

Gong, C., Shaikh, S., Wang, J., Zaidi, T., Grundke, I., & Iqbal, K. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65020732.x · Cited by 440 · see citing works

Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban

James, J. T., & Dubery, I. A. (2009) · Molecules · doi:10.3390/molecules14103922 · Cited by 399 · see citing works

Complementary and alternative medicine use among elderly persons: one-year analysis of a Blue Shield Medicare supplement

Astin, J. A., Pelletier, K. R., Marie, A., & Haskell, W. L. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.1.m4 · Cited by 291 · see citing works

PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus

Vogelsberg-Ragaglia, V., Schuck, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7630 · Cited by 281 · see citing works

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B

Wang, J.-Z., Gong, C.-X., Zaidi, T., Grundke-Iqbal, I., & Iqbal, K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4854 · Cited by 269 · see citing works

Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats

Gupta, Y. K., Kumar, M., & Srivastava, A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01044-4 · Cited by 253 · see citing works

Effect of <i>Centella asiatica</i> on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats

Veerendra Kumar, M., & Gupta, Y. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03842.x · Cited by 249 · see citing works

Tanshinones Inhibit Amyloid Aggregation by Amyloid-β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells

Wang, Q., Yu, X., Patal, K., Hu, R., Chuang, S. S. C., Zhang, G., & Zheng, J. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400051e · Cited by 205 · see citing works

Oligomerization and Toxicity of β-Amyloid-42 Implicated in Alzheimer's Disease

El‐Agnaf, O. M. A., Mahil, D. S., PATEL, B. P., & Austen, B. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3051 · Cited by 196 · see citing works

Signaling Events in Amyloid β-Peptide-induced Neuronal Death and Insulin-like Growth Factor I Protection

Wei, W., Wang, X., & Kusiak, J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111704200 · Cited by 190 · see citing works

Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica

Wattanathorn, J., Mator, L., Muchimapura, S., Tong-un, T., Pasurivong, O., Piyawatkul, N., Yimtae, K., Sripanidkulchai, B., & Singkhoraard, J. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.11.038 · Cited by 179 · see citing works

<i>Centella asiatica</i> extract selectively decreases amyloid <i>β</i> levels in hippocampus of Alzheimer's disease animal model

Dhanasekaran, M., Holcomb, L. A., Hitt, A. R., Tharakan, B., Porter, J. W., Young, K. A., & Manyam, B. V. (2009) · Phytotherapy Research · doi:10.1002/ptr.2405 · Cited by 175 · see citing works

Accuracy, precision, and reliability of chemical measurements in natural products research

Betz, J. M., Brown, P. N., & Roman, M. C. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.09.011 · Cited by 171 · see citing works

Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

Xu, M.-F., Xiong, Y.-Y., Liu, J.-K., Qian, J.-J., Zhu, L., & Gao, J. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.3 · Cited by 156 · see citing works

Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis

Wei, W. (2002) · Brain · doi:10.1093/brain/awf205 · Cited by 155 · see citing works

Restoration of biological activity of Alzheimer abnormally phosphorylated τ by dephosphorylation with protein phosphatase-2A, −2B and −1

Wang, J., Grundke, I., & Iqbal, K. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00316-k · Cited by 154 · see citing works

<i>Centella asiatica</i> accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro

Soumyanath, A., Zhong, Y.-P., Yu, X., Bourdette, D., Koop, D. R., Gold, S. A., & Gold, B. G. (2005) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.57.9.0018 · Cited by 150 · see citing works

Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1

Han, J., Miyamae, Y., Shigemori, H., & Isoda, H. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.049 · Cited by 146 · see citing works

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

Braak, H., Zetterberg, H., Tredici, K. D., & Blennow, K. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1139-0 · Cited by 141 · see citing works

Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H2O2-induced apoptosis in primary cortical neurons

Kim, J., Lee, S., Shim, J., Kim, H. W., Kim, J., Jang, Y. J., Yang, H. S., Park, J., Choi, S. H., Yoon, J. H., et al. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.02.004 · Cited by 131 · see citing works

Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats

Haleagrahara, N., & Ponnusamy, K. (2010) · The Journal of Toxicological Sciences · doi:10.2131/jts.35.41 · Cited by 123 · see citing works

Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

Bang, O. Y., Hong, H., Kim, D. H., Kim, H., Boo, J. H., Huh, K., & Mook‐Jung, I. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.017 · Cited by 123 · see citing works

Transgenic mice expressing Alzheimer amyloid precursor proteins

Hsiao, K. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00045-x · Cited by 119 · see citing works

Hyperphosphorylation of Tau Induced by Naturally Secreted Amyloid-β at Nanomolar Concentrations Is Modulated by Insulin-dependent Akt-GSK3β Signaling Pathway

Tokutake, T., Kasuga, K., Yajima, R., Sekine, Y., Tezuka, T., Nishizawa, M., & Ikeuchi, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.348300 · Cited by 117 · see citing works

Centella asiaticaExtract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action

Soumyanath, A., Zhong, Y.-P., Henson, E., Wadsworth, T. L., Bishop, J., Gold, B. G., & Quinn, J. F. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/381974 · Cited by 112 · see citing works

Inhibitory Effects ofCentella asiaticaWater Extract and Asiaticoside on Inducible Nitric Oxide Synthase During Gastric Ulcer Healing in Rats

Guo, J., Cheng, C. L., & Koo, M. W. L. (2004) · Planta Medica · doi:10.1055/s-2004-835843 · Cited by 110 · see citing works

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis

Zhang, X., Wu, J., Dou, Y., Xia, B., Rong, W., Rimbach, G., & Lou, Y. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.01.006 · Cited by 99 · see citing works

Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway

Huang, H.-C., Tang, D., Xu, K., & Jiang, Z.-F. (2014) · Journal of Receptor and Signal Transduction Research · doi:10.3109/10799893.2013.848891 · Cited by 97 · see citing works

Attenuation of β -Amyloid-Induced Oxidative Cell Death by Sulforaphane via Activation of NF-E2-Related Factor 2

Lee, C., Park, G. H., Lee, S., & Jang, J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/313510 · Cited by 97 · see citing works

Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats

Gupta, R., & Flora, S. J. S. (2006) · Journal of Applied Toxicology · doi:10.1002/jat.1131 · Cited by 94 · see citing works

Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein

Miyamae, Y., Kurisu, M., Murakami, K., Han, J., Isoda, H., Irie, K., & Shigemori, H. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.08.001 · Cited by 86 · see citing works

Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the β-amyloid precursor protein

Sopher, B. L., Fukuchi, K.-I., Smith, A. C., Leppig, K. A., Furlong, C. E., & Martin, G. M. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90092-2 · Cited by 84 · see citing works

Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats

(2012) · doi:10.1007/s10072-012-1163-1 · Cited by 82 · see citing works

Use of Alternative Therapies in Older Outpatients in the United States and Japan: Prevalence, Reporting Patterns, and Perceived Effectiveness

Flaherty, J. H., Takahashi, R., Teoh, J. Y., Kim, J. I., Habib, S., Ito, M., & Matsushita, S. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.10.m650 · Cited by 76 · see citing works

Neurodegenerative mechanisms in alzheimer disease

Sopher, B. L., Fukuchi, K., Kavanagh, T. J., Furlong, C. E., & Martin, G. M. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02814999 · Cited by 75 · see citing works

Mitochondrial Ferritin Attenuates β -Amyloid-Induced Neurotoxicity: Reduction in Oxidative Damage Through the Erk/P38 Mitogen-Activated Protein Kinase Pathways

Wu, W.-S., Zhao, Y., Shi, Z.-H., Chang, S.-Y., Nie, G., Duan, X.-L., Zhao, S.-M., Wu, Q., Yang, Z.-L., Zhao, B.-L., et al. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4285 · Cited by 73 · see citing works

In vitro model of neurotoxicity of A? 1?42 and neuroprotection by a pentapeptide: irreversible events during the first hour

Datki, Z., Papp, R., Zádori, D., Soós, K., Fülöp, L., Juhász, A., Laskay, G., Hetényi, C., MIHALIK, E., & Zarándi, M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.08.007 · Cited by 72 · see citing works

Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria

Shinomol, G. K., & ., M. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.04.010 · Cited by 69 · see citing works

Advanced glycation endproduct precursor alters intracellular amyloid- β/AβPP carboxy-terminal fragment aggregation and cytotoxicity

Woltjer, R. L., Maezawa, I., Ou, J. J., Montine, K. S., & Montine, T. J. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2003-5607 · Cited by 69 · see citing works

Caffeoylquinic Acid-Rich Purple Sweet Potato Extract, with or without Anthocyanin, Imparts Neuroprotection and Contributes to the Improvement of Spatial Learning and Memory of SAMP8 Mouse

Sasaki, K., Han, J., Shimozono, H., Villareal, M. O., & Isoda, H. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3041484 · Cited by 60 · see citing works

Proteomic study of amyloid beta (25–35) peptide exposure to neuronal cells: Impact on APE1/Ref‐1's protein–protein interaction

Mantha, A. K., Dhiman, M., Taglialatela, G., Perez‐Polo, R. J., & MITRA, S. P. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23018 · Cited by 56 · see citing works

Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells

Wanakhachornkrai, O., Pongrakhananon, V., Chunhacha, P., Wanasuntronwong, A., Vattanajun, A., Tantisira, B., Pithi Chanvorachote, B., & Tantisira, M. H. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-204 · Cited by 56 · see citing works

Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons

Zhang, Z., Zhao, R., Qi, J., Wen, S., Tang, Y., & Wang, D. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22563 · Cited by 48 · see citing works

Enhancement of Amygdaloid Neuronal Dendritic Arborization by Fresh Leaf Juice of Centella asiatica (Linn) during Growth Spurt Period in Rats

Mohandas Rao, K. G., Rao, M. S. R., & Rao, S. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nem079 · Cited by 45 · see citing works

Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment

Woltjer, R. L., McMahan, W., Milatović, D., Kjerulf, J. D., Shie, F., Rung, L. G., Montine, K. S., & Montine, T. J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.10.003 · Cited by 38 · see citing works

Neuroprotection of Ilex latifolia and caffeoylquinic acid derivatives against excitotoxic and hypoxic damage of cultured rat cortical neurons

Kim, J. Y., Lee, H. K., Hwang, B. Y., Kim, S., Yoo, J. K., & Seong, Y. H. (2012) · Archives of Pharmacal Research · doi:10.1007/s12272-012-0620-y · Cited by 37 · see citing works

The antiepileptic effect of Centella asiatica on the activities of Na + /K + , Mg 2+ and Ca 2+ -ATPases in rat brain during pentylenetetrazol-induced epilepsy

Rajendra, W., Visweswari, G., Prasad, K. S. S., & Lokanatha, V. (2010) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.64504 · Cited by 36 · see citing works

3,4,5-tri-O-caffeoylquinic acid inhibits amyloid β-mediated cellular toxicity on SH-SY5Y cells through the upregulation of PGAM1 and G3PDH

Miyamae, Y., Han, J., Sasaki, K., Terakawa, M., Isoda, H., & Shigemori, H. (2011) · Cytotechnology · doi:10.1007/s10616-011-9341-1 · Cited by 32 · see citing works

Caffeic acid ester fraction from Erigeron breviscapus inhibits microglial activation and provides neuroprotection

Wang, S., Guo, H., Hu, L., Liu, Y., Wang, Y.-F., Kang, L.-Y., & Gao, X. (2012) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-012-1114-y · Cited by 25 · see citing works

Dose-dependent folic acid and memantine treatments promote synergistic or additive protection against Aβ(25–35) peptide-induced apoptosis in SH-SY5Y cells mediated by mitochondria stress-associated death signals

Chen, T., Tang, M.-C., Chou, C.-H., Chiu, M., & Huang, R.-F. S. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.09.015 · Cited by 22 · see citing works

Indirubin-3′-monoxime inhibits β-amyloid-induced neurotoxicity in neuroblastoma SH-SY5Y cells

Zhang, S., Zhang, Y., Xu, L., Lin, X., Lu, J., Di, Q., Shi, J., & Xu, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.11.030 · Cited by 22 · see citing works

Caffeic Acid Ester Fraction from Erigeron Breviscapus Inhibits Microglial Activation and Provides Neuroprotection

王少峡, 郭虹, 胡利民, Liu, Y., 王跃飞, 康立源, & 高秀梅 (2012) · Chinese Journal of Integrative Medicine · Cited by 22 · see citing works

1,5-dicaffeoylquinic acid protects primary neurons from amyloid β 1-42-induced apoptosis via PI3K/Akt signaling pathway.

Xiao, H., Cao, X., Wang, L., Run, X., Su, Y., Cheng, T., Sheng-gang, S., & Liang, Z. (2011) · PubMed · Cited by 21 · see citing works

Quality Assurance of Herbal Raw Materials in Supply Chain: Challenges and Opportunities

Govindaraghavan, S. (2008) · Journal of Dietary Supplements · doi:10.1080/19390210802332810 · Cited by 15 · see citing works

Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity

Park, S. S., Jung, H., Kim, Y., Park, T. K., Kim, C., Choi, H., Mook‐Jung, I. H., Koo, E. H., & Park, S. A. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12032 · Cited by 14 · see citing works

Pre-aggregated Aβ1–42 peptide increases tau aggregation and hyperphosphorylation after short-term application

Ott, S., Henkel, A. W., Henkel, M. K., Redzic, Z. B., Kornhuber, J., & Wiltfang, J. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0671-7 · Cited by 13 · see citing works

Wild‐type, Flemish, and Dutch amyloid‐β exhibit different cytotoxicities depending on Aβ40 to Aβ42 interaction time and concentration ratio

Shahnawaz, M., Sharoar, M. G., Shin, S. Y., & Park, I. (2013) · Journal of Peptide Science · doi:10.1002/psc.2531 · Cited by 9 · see citing works

EVALUATION OF PHYTOCHEMICALS, ANTIOXIDANT ACTIVITY AND NUTRIENT CONTENT OF CENTELLA ASIATICA (L.) URBAN LEAVES FROM DIFFERENT LOCALITIES OF ASSAM

Saikia, S. U. A. L. R. (2012) · International Journal of Pharma and Bio Sciences · Cited by 7 · see citing works

NRF2 as a Therapeutic Target in Neurodegenerative Diseases

Brandes, M. S., & Gray, N. E. (2020) · ASN Neuro · doi:10.1177/1759091419899782 · Cited by 297 · see citing works

Centella asiatica: Phytochemistry and mechanisms of neuroprotection and cognitive enhancement

Gray, N. E., Alcazar Magana, A., Lak, P., Wright, K. M., Quinn, J., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-017-9528-y · Cited by 299 · see citing works

Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

Magaña, A. A., Kamimura, N., Soumyanath, A., Stevens, J. F., & Maier, C. S. (2021) · The Plant Journal · doi:10.1111/tpj.15390 · Cited by 285 · see citing works

Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine

Nabavi, S. F., Tejada, S., Setzer, W. N., Gortzi, O., Sureda, A., Braidy, N., Daglia, M., Manayi, A., & Nabavi, S. M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160325120625 · Cited by 152 · see citing works

Current Advances in Naturally Occurring Caffeoylquinic Acids: Structure, Bioactivity, and Synthesis

Liu, W., Li, J., Zhang, X., Zu, Y., Yue, Y., Liu, W., Xu, Z., Gao, H., Sun, X., Jiang, X., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03804 · Cited by 140 · see citing works

Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death

Huang, L., McClatchy, D. B., Maher, P. A., Liang, Z., Diedrich, J. K., Soriano‐Castell, D., Goldberg, J., Shokhirev, M. N., Yates, J. R., Schubert, D. A., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03020-9 · Cited by 129 · see citing works

Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice

Gray, N. E., Harris, C. J., Quinn, J. F., & Soumyanath, A. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.01.013 · Cited by 123 · see citing works

Protective effect of Centella asiatica against D-galactose and aluminium chloride induced rats: Behavioral and ultrastructural approaches

Chiroma, S. M., Baharuldin, M. T. H., Taib, C. N. M., Amom, Z., Jagadeesan, S., Adenan, M. I., & Moklas, M. A. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.111 · Cited by 96 · see citing works

Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction

Gray, N. E., Sampath, H., Zweig, J. A., Quinn, J. F., & Soumyanath, A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142217 · Cited by 90 · see citing works

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86 · see citing works

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice

Gray, N. E., Zweig, J. A., Caruso, M., Zhu, J. Y., Wright, K. M., Quinn, J. F., & Soumyanath, A. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.09.002 · Cited by 85 · see citing works

Recent Updates in Neuroprotective and Neuroregenerative Potential of Centella asiatica.

Lokanathan, Y., Omar, N., Puzi, N. N. A., Saim, A. B., & Idrus, R. B. H. (2016) · Europe PMC (PubMed Central) · Cited by 82 · see citing works

<i>Centella asiatica</i> increases hippocampal synaptic density and improves memory and executive function in aged mice

Gray, N. E., Zweig, J. A., Caruso, M., Martin, M. D., Zhu, J. Y., Quinn, J. F., & Soumyanath, A. (2018) · Brain and Behavior · doi:10.1002/brb3.1024 · Cited by 76 · see citing works

Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus

Chiroma, S. M., Baharuldin, M. T. H., Taib, C. N. M., Amom, Z., Jagadeesan, S., Adenan, M. I., Mahdi, O., & Moklas, M. A. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081871 · Cited by 69 · see citing works

Chemical Structure and Biological Activities of Secondary Metabolites from Salicornia europaea L.

Kim, S., Lee, E.-Y., Hillman, P. F., Ko, J., Yang, I., & Nam, S. (2021) · Molecules · doi:10.3390/molecules26082252 · Cited by 64 · see citing works

C-Glycosylflavones Alleviate Tau Phosphorylation and Amyloid Neurotoxicity through GSK3β Inhibition

Liang, Z., Zhang, B., Su, W., Williams, P. G., & Li, Q. X. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00059 · Cited by 64 · see citing works

Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice

Matthews, D. G., Caruso, M. A., Magaña, A. A., Wright, K. M., Maier, C. S., Stevens, J. F., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2020) · Nutrients · doi:10.3390/nu12113488 · Cited by 59 · see citing works

<i>Centella asiatica</i> Attenuates Mitochondrial Dysfunction and Oxidative Stress in A<i>β</i>‐Exposed Hippocampal Neurons

Gray, N. E., Zweig, J. A., Matthews, D. G., Caruso, M., Quinn, J. F., & Soumyanath, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7023091 · Cited by 60 · see citing works

The Regulatory effect of chlorogenic acid on gut-brain function and its mechanism: A systematic review

Zeng, L., Xiang, R., Fu, C.-Y., Qu, Z., & Liu, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112831 · Cited by 54 · see citing works

A Comprehensive Review of C. capsularis and C. olitorius: A Source of Nutrition, Essential Phytoconstituents and Pharmacological Activities

Biswas, A., Dey, S., Huang, S., Deng, Y. J., Birhanie, Z. M., Zhang, J., Akhter, D., Liu, L., & Li, D. (2022) · Antioxidants · doi:10.3390/antiox11071358 · Cited by 51 · see citing works

Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification

Gray, N. E., Zweig, J. A., Murchison, C., Caruso, M., Matthews, D. G., Kawamoto, C., Harris, C. J., Quinn, J. F., & Soumyanath, A. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.072 · Cited by 49 · see citing works

Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial

Wright, K. M., Bollen, M., David, J., Speers, A. B., Brandes, M. S., Gray, N. E., Magaña, A. A., McClure, C., Stevens, J. F., Maier, C. S., et al. (2022) · Antioxidants · doi:10.3390/antiox11020215 · Cited by 48 · see citing works

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes, M. Y. S. D., Dobrachinski, F., Silva, H. B. L., Lopes, J. P., Gonçalves, F. Q., Soares, F. A. A., Porciúncula, L. O., de Andrade, G. M., Cunha, R. A., & Tomé, Â. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-89964-0 · Cited by 47 · see citing works

Free radical biology in neurological manifestations: mechanisms to therapeutics interventions

Tripathi, R. S., Gupta, R. V., Sahu, M., Srivastava, D., Das, A., Ambasta, R. K., & Kumar, P. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16693-2 · Cited by 52 · see citing works

Integration of mass spectral fingerprinting analysis with precursor ion (MS1) quantification for the characterisation of botanical extracts: application to extracts of Centella asiatica (L.) Urban

Magaña, A. A., Wright, K. M., Vaswani, A., Caruso, M. A., Reed, R. L., Bailey, C. F., Nguyen, T. T. M., Gray, N. E., Soumyanath, A., Quinn, J. F., et al. (2020) · Phytochemical Analysis · doi:10.1002/pca.2936 · Cited by 43 · see citing works

Toxicological evaluation of ethanolic extract from Stevia rebaudiana Bertoni leaves: Genotoxicity and subchronic oral toxicity

Zhang, Q., Yang, H., Li, Y., Liu, H., & Jia, X. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.03.021 · Cited by 45 · see citing works

Molecular mechanism of the binding of 3,4,5-tri-O-caffeoylquinic acid to human serum albumin: Saturation transfer difference NMR, multi-spectroscopy, and docking studies

Tang, B., Huang, Y., Yang, H., Tang, P., & Li, H. (2016) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2016.10.017 · Cited by 44 · see citing works

Prolonged Treatment with Centella asiatica Improves Memory, Reduces Amyloid-β Pathology, and Activates NRF2-Regulated Antioxidant Response Pathway in 5xFAD Mice

Zweig, J. A., Brandes, M. S., Brumbach, B. H., Caruso, M. A., Wright, K. M., Quinn, J. F., Soumyanath, A., & Gray, N. E. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210271 · Cited by 43 · see citing works

Carqueja (Baccharis trimera) Protects against Oxidative Stress andβ-Amyloid-Induced Toxicity inCaenorhabditis elegans

Paiva, F. A., Bonomo, L., Boasquívis, P. F., de Paula, I. T. B. R., Guerra, J. F. D. C., Leal, W. M., Silva, M. E., Pedrosa, M. L., & Oliveira, R. D. P. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/740162 · Cited by 38 · see citing works

Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging

Zweig, J. A., Brandes, M. S., Brumbach, B. H., Caruso, M. A., Wright, K. M., Quinn, J. F., Soumyanath, A., & Gray, N. E. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.11.019 · Cited by 35 · see citing works

Metabolomics-derived insights into the manipulation of terpenoid synthesis in Centella asiatica cells by methyl jasmonate

Tugizimana, F., Ncube, E. N., Steenkamp, P. A., & Dubery, I. A. (2015) · Plant Biotechnology Reports · doi:10.1007/s11816-015-0350-y · Cited by 29 · see citing works

Differentiation of Three Centella Species in Australia as Inferred from Morphological Characteristics, ISSR Molecular Fingerprinting and Phytochemical Composition

Alqahtani, A. S., Cho, J., Wong, K. H., Li, K. M., Razmovski‐Naumovski, V., & Li, G. Q. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01980 · Cited by 26 · see citing works

Quinic and caffeic acids derivatives: Affecting antioxidant capacities and phenolics contents of certain therapeutic and specialty crops employing water and ethanolic extracts

Islam, S., Adam, Z., & Akanda, J. H. (2024) · Food Chemistry Advances · doi:10.1016/j.focha.2024.100693 · Cited by 25 · see citing works

STX, a Novel Membrane Estrogen Receptor Ligand, Protects Against Amyloid-β Toxicity

Gray, N. E., Zweig, J. A., Kawamoto, C., Quinn, J. F., & Copenhaver, P. F. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150756 · Cited by 25 · see citing works

Isochlorogenic acid A promotes melanin synthesis in B16 cell through the β-catenin signal pathway

Mamat, N., Dou, J., Lu, X., Eblimit, A., & Akber, A. H. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx072 · Cited by 25 · see citing works

Structural Stabilization of Human Transthyretin by Centella asiatica (L.) Urban Extract: Implications for TTR Amyloidosis

Eze, F. N., Leelawatwattana, L., & Prapunpoj, P. (2019) · Biomolecules · doi:10.3390/biom9040128 · Cited by 24 · see citing works

Variability, association and path analysis of centellosides and agro-morphological characteristics in Iranian Centella asiatica (L.) Urban ecotypes

Nav, S. N., Ebrahimi, S. N., Sonboli, A., & Mirjalili, M. H. (2021) · South African Journal of Botany · doi:10.1016/j.sajb.2021.03.006 · Cited by 24 · see citing works

Metabolite profiling of the undifferentiated cultured cells and differentiated leaf tissues of Centella asiatica

Ncube, E. N., Steenkamp, P. A., Madala, N. E., & Dubery, I. A. (2017) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1189-4 · Cited by 21 · see citing works

Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges

Wright, K. M., McFerrin, J., Magaña, A. A., Roberts, J., Caruso, M. A., Kretzschmar, D., Stevens, J. F., Maier, C. S., Quinn, J. F., & Soumyanath, A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.799137 · Cited by 20 · see citing works

Phytochemical Analysis of Polyphenols in Leaf Extract from Vernonia amygdalina Delile Plant Growing in Uganda

Nowak, J., Kiss, A. K., Wambebe, C. O., Katuura, E., & Kuźma, Ł. (2022) · Applied Sciences · doi:10.3390/app12020912 · Cited by 20 · see citing works

Quantification of caffeoylquinic acids and triterpenes as targeted bioactive compounds of Centella Asiatica in extracts and formulations by liquid chromatography mass spectrometry

Yang, L., Marney, L. C., Magaña, A. A., Choi, J., Wright, K. M., McFerrin, J., Gray, N. E., Soumyanath, A., Stevens, J. F., & Maier, C. S. (2023) · Journal of Chromatography Open · doi:10.1016/j.jcoa.2023.100091 · Cited by 19 · see citing works

A GDSL lipase-like from Ipomoea batatas catalyzes efficient production of 3,5-diCQA when expressed in Pichia pastoris

Miguel, S., Legrand, G., Duriot, L., Delporte, M., Menin, B., Michel, C., Olry, A., Châtaigné, G., Salwiński, A., Bygdell, J., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01387-1 · Cited by 19 · see citing works

Chlorogenic Acids Biosynthesis in Centella asiatica Cells Is not Stimulated by Salicylic Acid Manipulation

Ncube, E. N., Steenkamp, P. A., Madala, N. E., & Dubery, I. A. (2016) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-016-2024-9 · Cited by 18 · see citing works

Caffeoylquinic Acids with Potential Biological Activity from Plant In vitro Cultures as Alternative Sources of Valuable Natural Products

Skała, E., Makowczyńska, J., Wieczfińska, J., Kowalczyk, T., & Sitarek, P. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200212115826 · Cited by 18 · see citing works

Neuromodulatory Activity of Dietary Phenolics Derived from Corchorus olitorius L.

Wagdy, R., Abdel-Kader, R. M., El‐Khatib, A. H., Linscheid, M. W., Hamdi, N., & Handoussa, H. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14587 · Cited by 17 · see citing works

Centella asiatica Water Extract Shows Low Potential for Cytochrome P450–Mediated Drug Interactions

Wright, K. M., Magaña, A. A., Laethem, R. M., Moseley, C. L., Banks, T. T., Maier, C. S., Stevens, J. F., Quinn, J. F., & Soumyanath, A. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.090860 · Cited by 15 · see citing works

Attenuation of methylglyoxal-induced glycation and cellular dysfunction in wound healing by Centella cordifolia

Alqahtani, A. S., Li, K. M., Razmovski‐Naumovski, V., Kam, A., Alam, P., & Li, G. Q. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.11.016 · Cited by 15 · see citing works

Organic anion transporter 3 (OAT3)-mediated transport of dicaffeoylquinic acids and prediction of potential drug-drug interaction

Wang, Y., Ren, J., Sun, Q., Zhang, Z., Lin, Y., Deng, S., Wang, C., Huo, X., Sun, C., Tian, X., et al. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.03.022 · Cited by 15 · see citing works

3,5-Dicaffeoylquinic Acid Lowers 3T3-L1 Mitotic Clonal Expansion and Adipocyte Differentiation by Enhancing Heme Oxygenase-1 Expression

Raineri, A., Campagnari, R., Toso, R. D., Copetti, S., Gomez‐Lira, M., & Menegazzi, M. (2021) · Molecules · doi:10.3390/molecules26165027 · Cited by 14 · see citing works

Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression

Schuck, F., Schmitt, U., Reinhardt, S., Freese, C., Lee, I., Thines, E., Efferth, T., & Endres, K. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.08.001 · Cited by 14 · see citing works

Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults

Wright, K. M., Bollen, M., David, J., Mepham, B., Magaña, A. A., McClure, C., Maier, C. S., Quinn, J. F., & Soumyanath, A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1228030 · Cited by 13 · see citing works

The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule

Maezawa, I., Zou, B., Lucente, J. D., Cao, W., Pascual, C., Weerasekara, S., Zhang, M., Xie, X., Hua, D. H., & Jin, L. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161175 · Cited by 13 · see citing works

A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease

Abbas, S., Latif, M. S., Shafie, N. S., Ghazali, M. I., Abidin, N. A. Z., Mustafa, M. K., & Kormin, F. B. (2021) · Food Research · doi:10.26656/fr.2017.5(2).355 · Cited by 12 · see citing works

Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants

Meineck, M., Schuck, F., Abdelfatah, S., Efferth, T., & Endres, K. (2016) · Medicines · doi:10.3390/medicines3040030 · Cited by 12 · see citing works

Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila melanogaster

Holvoet, H., Long, D. M., Yang, L., Choi, J., Marney, L. C., Poeck, B., Maier, C. S., Soumyanath, A., Kretzschmar, D., & Strauß, R. (2023) · Nutrients · doi:10.3390/nu15184016 · Cited by 11 · see citing works

Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice

Varada, S., Chamberlin, S. R., Bui, L., Brandes, M. S., Gladen-Kolarsky, N., Harris, C., Hack, W. R., Neff, C. J., Brumbach, B. H., Soumyanath, A., et al. (2025) · Nutrients · doi:10.3390/nu17040729 · Cited by 13 · see citing works

Effect of high-frequency low-intensity pulsed electric field on protecting SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury via ERK pathway

Chen, W., Lin, G.-B., Kuo, Y.-Y., Hsieh, C.-H., Lu, C., Sun, Y., & Chao, C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250491 · Cited by 10 · see citing works

Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments

Pattanaik, S. K., Anil, P. M., Jena, S., & Rath, D. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120092 · Cited by 10 · see citing works

Identification of TrkB Binders from Complex Matrices Using a Magnetic Drug Screening Nanoplatform

Arituluk, Z. C., Horne, J., Adhikari, B., Steltzner, J., Mansur, S., Ahirwar, P., Velu, S. E., Gray, N. E., Ciesla, L. M., & Bao, Y. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00552 · Cited by 10 · see citing works

Stimulatory Effects of Acibenzolar-S-Methyl on Chlorogenic Acids Biosynthesis in Centella asiatica Cells

Ncube, E. N., Steenkamp, P. A., Madala, N. E., & Dubery, I. A. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01469 · Cited by 8 · see citing works

Comparative Analysis of Root Phenolic Profiles and Antioxidant Activity of Five Native and Invasive Solidago L. Species

Radušienė, J., Karpavičienė, B., Vilkickytė, G., Marksa, M., & Raudonė, L. (2024) · Plants · doi:10.3390/plants13010132 · Cited by 9 · see citing works

Safety Assessment of Centella asiatica -Derived Ingredients as Used in Cosmetics

Johnson, W., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., et al. (2023) · International Journal of Toxicology · doi:10.1177/10915818231158272 · Cited by 9 · see citing works

Perspective: Council for Responsible Nutrition Science in Session. Optimizing Health with Nutrition—Opportunities, Gaps, and the Future

Ho, E., Drake, V., Michels, A. J., Nkrumah-Elie, Y. M., Brown, L. L., Scott, J. M., Newman, J. W. I., Shukitt‐Hale, B., Soumyanath, A., Chilton, F. H., et al. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.05.015 · Cited by 9 · see citing works

Identification and evaluation of a novel tribenzamide derivative as an inhibitor targeting the entry of the respiratory syncytial virus

Issmail, L., Ramsbeck, D., Jäger, C., Henning, T., Kleinschmidt, M., Buchholz, M., & Grunwald, T. (2023) · Antiviral Research · doi:10.1016/j.antiviral.2023.105547 · Cited by 8 · see citing works

Characteristics of Phenolic Compounds in Peucedanum japonicum According to Various Stem and Seed Colors

Lee, C.-D., Cho, H., Shim, J., Tran, G. H., Lee, H.-D., Ahn, K. H., Yoo, E., Chung, M. J., & Lee, S. (2023) · Molecules · doi:10.3390/molecules28176266 · Cited by 8 · see citing works

Effects of Cooking Methods on Caffeoylquinic Acids and Radical Scavenging Activity of Sweet Potato

Kido, M., Yoshimoto, M., Sakao, K., Wada, K., & Hou, D. (2024) · Foods · doi:10.3390/foods13071101 · Cited by 8 · see citing works

Caffeoylquinic Acids

Woźniak, D., Nawrot-Hadzik, I., Kozłowska, W., Ślusarczyk, S., & Matkowski, A. (2021) · Springer eBooks · doi:10.1007/978-981-15-4148-3_23 · Cited by 8 · see citing works

Neuroprotective effect against amyloidogenic transthyretin aggregates - Induced cytotoxicity on human neuroblastoma cell by phenolic-rich Centella asiatica extract

Eze, F. N., Bunyapongpan, A., & Prapunpoj, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39159 · Cited by 7 · see citing works

Polymeric colloidal nanocarriers entrapped with Centella asiatica extract

Perez, A. G. M., Machado, J. M., Manhani, K. C., Léo, P., Noriega, P., & Zanin, M. H. A. (2020) · SN Applied Sciences · doi:10.1007/s42452-020-03681-3 · Cited by 7 · see citing works

Centella asiatica (Gotu kola) leaves

Thakurdesai, P. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00021-5 · Cited by 8 · see citing works

Lost in Translation? Finding Our Way To Effective Alzheimer’s Disease Therapies

Quinn, J. F. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179930 · Cited by 7 · see citing works

Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of C. asiatica Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity

Magaña, A. A., Vaswani, A., Brown, K., Jiang, Y., Alam, M. N., Caruso, M. A., Lak, P., Cheong, P. H., Gray, N. E., Quinn, J. F., et al. (2024) · Molecules · doi:10.3390/molecules29040838 · Cited by 6 · see citing works

Centella asiatica and its caffeoylquinic acid and triterpene constituents increase dendritic arborization of mouse primary hippocampal neurons and improve age-related locomotion deficits in Drosophila

Rowe, K., Gray, N. E., Zweig, J. A., Law, A. D., Techen, N., Maier, C. S., Soumyanath, A., & Kretzschmar, D. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1374905 · Cited by 6 · see citing works

Centella asiatica

Jantwal, A., Durgapal, S., Upadhyay, J., Rana, M. D., Tariq, M., Dhariwal, A., & Joshi, T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819212-2.00021-9 · Cited by 6 · see citing works

Phytochemical Profiling and Antioxidant Activity of True Leaves and Cotyledons of Adenocaulon himalaicum

Lee, S.-Y., Yoon, N., Uy, N. P., Choi, C.-H., & Lee, S. (2025) · ChemEngineering · doi:10.3390/chemengineering9020031 · Cited by 4 · see citing works

Potential Treatment Strategies of Dementia With Ayurvedic Medicines

Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816347-4.00009-x · Cited by 4 · see citing works

Centella asiatica and protection in neurodevelopment

Bolumbu, G., & Mitha, K. V. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90052-2.00042-1 · Cited by 4 · see citing works

Neuroprotective Role of Medicinal Plants from North Eastern Region of India

Bhattacharjee, B., Deka, B., Shivavedi, N., Bhat, H. R., Sinha, S. K., Ghosh, S. K., & Shakya, A. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815040197123010008 · Cited by 3 · see citing works

Reevaluating Alzheimer’s disease treatment: Can phytochemicals bridge the therapeutic Gap?

Roy, K. K., Mehta, D. K., & Das, R. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.04.014 · Cited by 3 · see citing works

Multiple broad spectrum Neuromodulatory effects of Bacopa monnieri and Centella asiatica: mechanistic considerations

Muralidhara, M., George, S., Rao, S. V., & Rajini, P. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19084-1.00020-x · Cited by 3 · see citing works

Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice

Matthews, D. G., Khorani, M., Bobe, G., Caruso, M. A., Magaña, A. A., Gray, N. E., Quinn, J. F., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2024) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823241296740 · Cited by 4 · see citing works

USP14 inhibitor IU1 alleviates amyloid-β mediated toxicity in Alzheimer's disease cell and worm models

Ariyath, A., Hone, E., Fernando, W. M. A. D. B., Pedrini, S., Martins, R. N., & Bharadwaj, P. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261422775 · Cited by 2 · see citing works

Unlocking the Power of Plant-Derived Natural Products: Therapeutic Benefits for Cognitive Health and Neuropsychiatric Symptoms in Dementia-Related Diseases

小山, 幸., Pham, L., Murakawa, Y., Ogawa, Y., 寺内加奈子, & Davis, K. (2026) · Plants · doi:10.3390/plants15111619 · Cited by 2 · see citing works

Influence of Bilberry Extract on Neuronal Cell Toxicity

König, S., Bakuradze, T., Jesser, S., Sreeja, H. A., Carlsson, M. J., Fahrer, J., Kins, S., & Richling, E. (2024) · Biology · doi:10.3390/biology13060376 · Cited by 2 · see citing works

Preparative isolation of caffeoylquinic acid isomers from Kuding tea by salt‐containing aqueous two‐phase extraction and purification by high‐speed countercurrent chromatography

Liu, D., Liu, X., & Zhang, X. (2019) · Separation Science Plus · doi:10.1002/sscp.201900017 · Cited by 2 · see citing works

Preventive Role and Mechanism of Herbal Medicine in Alzheimer’s Disease with Special Reference to Phenolic Compounds

Bhakshu, L. M., Kamsala, R. V., & Venkataraju, R. R. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-8158-5_17 · Cited by 2 · see citing works

Asiatic acid improves mitochondrial function, activates antioxidant response in the mouse brain and improves cognitive function in beta-amyloid overexpressing micePreprint

Varada, S., Chamberlin, S. R., Bui, L., Brandes, M. S., Gladen-Kolarsky, N., Harris, C., Hack, W. R., Brumbach, B. H., Quinn, J. F., & Gray, N. E. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.21.581270 · Cited by 2 · see citing works

Decoding eggplant fruit: Multi-omics profiling of caffeoyl-CoA-3-OMT expression

Dave, K., Kaushik, P., Patil, N., Dhariwal, R., Sharma, M., Yadav, A., Dhanda, P. S., & Jain, M. (2024) · South African Journal of Botany · doi:10.1016/j.sajb.2024.09.044 · Cited by 1 · see citing works

Development of a Proton Spin Network Fingerprint Library to Support Mass Spectrometry-Based Identification of Pharmacophore-Bearing Constituents in the Botanical Supplement Centella asiatica

Neiheisel, S., Uchenik, D., Marney, L. C., Maier, C. S., Gray, N. E., Soumyanath, A., & Harinantenaina, L. (2025) · Journal of Natural Products · doi:10.1021/acs.jnatprod.4c01486 · Cited by 1 · see citing works

Diversity, characterization of medicinal potential, and analysis of understory plant species on the lowland tropical forest floor in Mount Ciremai National Park, Indonesia

Sudiana, E., Ismail, A. Y., Permana, D. I., Supartono, T., Nasihin, I., Hendrayana, Y., Adhya, I., & Aminudin, S. A. A. (2025) · Brazilian Journal of Biology · doi:10.1590/1519-6984.299320 · Cited by 2 · see citing works

The Effects of Centella asiatica Aqueous Extract on some Blood Parameters in Rat Model of Alzheimer's Disease

Doulah, A., & Rafieirad, M. (2017) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works

Industrial Chicory and Its Specialized Metabolites: Diversification of Uses and Varietal Selection

Hilbert, J., & Rambaud, C. (2023) · Reference series in phytochemistry · doi:10.1007/978-3-031-04195-2_134-1 · Cited by 1 · see citing works

Caffeoylquinic Acid Mitigates Neuronal Loss and Cognitive Decline in 5XFAD Mice Without Reducing the Amyloid-β Plaque Burden

Suganuma, T., Hatori, S., Chen, C., Hori, S., Kanuka, M., Liu, C.-Y., Tatsuzawa, C., Yanagisawa, M., & Hayashi, Y. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240033 · Cited by 1 · see citing works

Industrial Chicory and Its Specialized Metabolites: Diversification of Uses and Varietal Selection

Hilbert, J., & Rambaud, C. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-38663-3_134 · Cited by 1 · see citing works

Caffeoylquinic Acids

Woźniak, D., Nawrot-Hadzik, I., Kozłowska, W., Ślusarczyk, S., & Matkowski, A. (2020) · Springer eBooks · doi:10.1007/978-981-13-1745-3_23-1

Dicaffeoylquinic Acid–Rich Sunflower Sprout Extract Attenuates High‐Fat Diet‐Induced Obesity in Rats

Chaisit, S., Limprasutr, V., Wongtayan, A., Islamie, R., Cheevarungnapakul, K., Sirikantaramas, S., & Rodsiri, R. (2026) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/adpp/3192392

Metabolomics-derived insights into the metabolic regulation and control of centellosides in hairy root cultures of Centella asiatica

Garcia-Baeza, A. (2023) · theses.fr (ABES) · doi:10.70675/fac89ff8z2aacz428ez92a9zc7680f67d72c

CERES: Cluster‑enabled regression of extract signatures for discovery of NRF2 activators in Centella asiatica by ion-mobility mass spectrometry, k-medoids clustering and ensemble Lasso regression

Marney, L. C., Choi, J., Alenicheva, V., Cabey, K., Beck, T., Milner, E. R., Gray, N. E., Soumyanath, A., Maier, C. S., Stevens, J. F., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0354664

Natural products targeting mitochondrial homeostasis: a four-dimensional framework integrating dynamics, mitophagy, pharmacokinetics, and translational safety

Xiang, Z.-Y., Yang, X.-H., Lan, W.-Y., Xiao, X.-Y., Huang, Q., & Yang, L. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1911495

Pharmacological Activities of Centella asiatica: A Systematic Review of Preclinical and Clinical Evidence on Cardiovascular, Neurological, Antioxidant, and Anti-inflammatory Effects

Yuwadee, A., Boonprasert, K., & Na‐Bangchang, K. (2026) · Planta Medica · doi:10.1055/a-2969-6239

Centella asiatica Protects Against the Toxic Effects of Intracellular beta-amyloid Accumulation

Gray, N. E., Morré, J., Kelley, J., Maier, C. S., Stevens, F., Quinn, J. F., & Soumyanath, A. (2013) · Planta Medica · doi:10.1055/s-0033-1348596 · Cited by 4 · see citing works

Caffeolyquinic Acid Protects against Alzheimer’s Disease through Inhibition of Amyloid Beta-Induced Toxicity

Han, J., Omri, A. E., Sasaki, K., & Isoda, H. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00081-4 · Cited by 2 · see citing works

Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction

Gray, N. E., Sampath, H., Zweig, J. A., Quinn, J. F., & Soumyanath, A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142217 · Cited by 90 · see citing works

Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification

Gray, N. E., Zweig, J. A., Murchison, C., Caruso, M., Matthews, D. G., Kawamoto, C., Harris, C. J., Quinn, J. F., & Soumyanath, A. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.072 · Cited by 49 · see citing works

Protective Effect of Di-O-Caffeoylquinic Acid on Human-Derived Neurotypic SH-SY5Y Cells Against Alzheimer’s Disease Amyloid-Beta-Induced Toxicity

Isoda, H., Han, J., & Shigemori, H. (2010) · Springer eBooks · doi:10.1007/978-90-481-3419-9_131