Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice

Gray, Nora E.; Harris, Christopher J.; Quinn, Joseph F.; Soumyanath, Amala

doi:10.1016/j.jep.2016.01.013

Cited by 124Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsNeurological Disorders and Treatments

Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice

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Gray, Nora E., Harris, Christopher J., Quinn, Joseph F., Soumyanath, Amala·2016·Journal of Ethnopharmacology

DOI 10.1016/j.jep.2016.01.013PMC PMC4764102

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Abstract

Ethnopharmacological relevance This study investigates the cognitive enhancing effects of the plant Centella asiatica which is widely used Ayurvedic and traditional Chinese medicine.Aim of the study The goal of this study was to determine the effects of a water extract of the medicinal plant Centella asiatica (CAW) on cognitive ability as well as mitochondrial and antioxidant response pathways in vivo.Materials and methods Old and young C57BL/6 mice were treated with CAW (2mg/mL) in their drinking water. Learning and memory was assessed using Morris Water Maze (MWM) and then tissue was collected and gene expression analyzed.Results CAW improved performance in the MWM in aged animals and had a modest effect on the performance of young animals. CAW also increased the expression of mitochondrial and antioxidant response genes in the brain and liver of both young and old animals. Expression of synaptic markers was also increased in the hippocampus and frontal cortex, but not in the cerebellum of CAW-treated animals.Conclusions These data indicate a cognitive enhancing effect of CAW in healthy mice. The gene expression changes caused by CAW suggest a possible effect on mitochondrial biogenesis, which in conjunction with activation of antioxidant response genes could contribute to cognitive improvement.

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Preclinical studies have demonstrated that Centella asiatica compounds exhibit antioxidant and anti-inflammatory activities, promote fibroblast proliferation, enhance collagen synthesis, and protect extracellular matrix integrity.
“Preclinical studies have demonstrated that these compounds exhibit potent antioxidant and anti-inflammatory activities, promote fibroblast proliferation, enhance collagen synthesis, and protect extracellular matrix integrity [16,17,19,22,23,24].”
From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [23]
The Results (page not provided) report that a Centella asiatica water extract increased antioxidant-response gene expression in young and aged mice. The Discussion cautions that the study measured gene expression, not antioxidant function. Our copy does not establish anti-inflammatory activity, fibroblast proliferation, collagen synthesis, or protection of extracellular matrix integrity. (LLM, conf=0.86)
Experimental — accuracy not yet measured
CAW treatment (200 mg/kg/d for four weeks) benefits aged WT mice in Morris water maze, object location, and novel object recognition.
“A treatment benefit of CAW (200 mg/kg/d for four weeks) in WT animals was previously reported both in male and female aged (20 month old) WT mice (as measured by Morris water maze, object location, and novel object recognition) [1,46].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [46]
Previous studies show CAW treatment is associated with elevated levels of NRF2-targeted ARE gene transcripts in Tg2576 primary neurons and hippocampus and cortex of young and aged WT mice.
“Previous studies in our laboratory show that CAW treatment is associated with elevated levels of NRF2-targeted ARE gene transcripts in Tg2576 primary neurons [27], as well as the hippocampus and cortex of young and aged WT mice [46].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [46]
Previous studies observed increased hippocampal and cortical mitochondrial gene expression and increased mitochondrial activity in response to CAW treatment.
“We have previously observed increased hippocampal and cortical mitochondrial gene expression [46] and increased mitochondrial activity [33] in response to CAW treatment.”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [46]

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Tyler, S. E. B., & Tyler, L. D. K. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.01.006 · Cited by 32 · see citing works
Differential expression of entorhinal cortex and hippocampal subfields α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors enhanced learning and memory of rats following administration of Centella asiatica
Wong, J. H., Muthuraju, S., Reza, F., Senik, M. H., Zhang, J., Yeo, N. A. B. M. Y., Chuang, H. G., Jaafar, H., Yusof, S. R., Mohamad, H., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.044 · Cited by 28 · see citing works
Centella asiatica Alters Metabolic Pathways Associated With Alzheimer’s Disease in the 5xFAD Mouse Model of ß-Amyloid Accumulation
Speers, A. B., García‐Jaramillo, M., Feryn, A. B., Matthews, D. G., Lichtenberg, T., Caruso, M. A., Wright, K. M., Quinn, J. F., Stevens, J. F., Maier, C. S., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.788312 · Cited by 26 · see citing works
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Hippocampal amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid GluA1 ( AMPA GluA1) receptor subunit involves in learning and memory improvement following treatment withCentella asiaticaextract in adolescent rats
Yeo, N. A. B. M. Y., Muthuraju, S., Wong, J. H., Mohammed, F. R., Senik, M. H., Zhang, J., Yusof, S. R., Jaafar, H., Adenan, M. L., Mohamad, H., et al. (2018) · Brain and Behavior · doi:10.1002/brb3.1093 · Cited by 26 · see citing works
Combined extract of Moringa oleifera and Centella asiatica modulates oxidative stress and senescence in hydrogen peroxide-induced human dermal fibroblasts
Hisam, E. E. A., Rofiee, M. S., Khalid, A. M., Jalaluddin, A. F., Yusof, M. I. M., Idris, M. H. M., Ramli, S., James, R. J., Yoeng, W. J., Teh, L. K., et al. (2018) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1708-23 · Cited by 25 · see citing works
Structural Stabilization of Human Transthyretin by Centella asiatica (L.) Urban Extract: Implications for TTR Amyloidosis
Eze, F. N., Leelawatwattana, L., & Prapunpoj, P. (2019) · Biomolecules · doi:10.3390/biom9040128 · Cited by 24 · see citing works
Neurotransmitter, Antioxidant and Anti-neuroinflammatory Mechanistic Potentials of Herbal Medicines in Ameliorating Autism Spectrum Disorder
Kardani, A., Soltani, A., Sewell, R. D. E., Shahrani, M., & Rafieian‐Kopaei, M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191112143940 · Cited by 23 · see citing works
Potential effect of herbal antidepressants on cognitive deficit: Pharmacological activity and possible molecular mechanism
Li, J., Zhao, Y., Sun, Y., & Kong, L. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112830 · Cited by 23 · see citing works
Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis
Musillo, C., Borgi, M., Saul, N., Möller, S., Luyten, W. H. M. L., Berry, A., & Cirulli, F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.001 · Cited by 22 · see citing works
Multitarget Activities of Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Against Alzheimer’s Disease
Chheng, C., Waiwut, P., Plekratoke, K., Chulikhit, Y., Daodee, S., Monthakantirat, O., Pitiporn, S., Musigavong, N., Kwankhao, P., & Boonyarat, C. (2020) · Pharmaceuticals · doi:10.3390/ph13050079 · Cited by 21 · see citing works
Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges
Wright, K. M., McFerrin, J., Magaña, A. A., Roberts, J., Caruso, M. A., Kretzschmar, D., Stevens, J. F., Maier, C. S., Quinn, J. F., & Soumyanath, A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.799137 · Cited by 20 · see citing works
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Mechanistic role and potential of Ayurvedic herbs as anti-aging therapies
Raina, K., Kumari, R., Thakur, P., Sharma, R., Singh, R., Thakur, A., Anand, V., Sharma, R., & Chaudhary, A. (2023) · Drug Metabolism and Personalized Therapy · doi:10.1515/dmpt-2023-0024 · Cited by 20 · see citing works
Anti-aging role of Chinese herbel medicine: an overview of scientific evidence from 2008 to 2018
Zhao, J., Xu, L., Liu, Y., Liu, Y., Xian, Y., Lin, Z., & Xu, F. (2020) · Annals of Palliative Medicine · doi:10.21037/apm.2020.04.09 · Cited by 20 · see citing works
The Impact of the hAPP695 SW Transgene and Associated Amyloid-β Accumulation on Murine Hippocampal Biochemical Pathways
Khorani, M., Bobe, G., Matthews, D. G., Magaña, A. A., Caruso, M. A., Gray, N. E., Quinn, J. F., Stevens, J. F., Soumyanath, A., & Maier, C. S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215084 · Cited by 18 · see citing works
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Role of Mandukparni (Centella asiatica Linn Urban) in neurological disorders: Evidence from ethnopharmacology and clinical studies to network enrichment analysis
Sharma, R., Banerjee, S., & Sharma, R. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105865 · Cited by 18 · see citing works
Involvement of mitochondria in Alzheimer’s disease pathogenesis and their potential as targets for phytotherapeutics
Maruthiyodan, S., Mumbrekar, K. D., & Guruprasad, K. P. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101868 · Cited by 17 · see citing works
Centella Asiatica Increased the Body Length Through the Modulation of Antioxidant in Rotenone-Induced Zebrafish Larvae
Khotimah, H., Darwitri, D., Yuliyani, T., Nuraenah, E., Zahara, E., Kalsum, U., Nurdiana, N., & Ali, M. M. (2018) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/1438 · Cited by 17 · see citing works
Potential Activities of Centella asiatica Leaf Extract against Pathogenic Bacteria‐Associated Biofilms and Its Anti‐Inflammatory Effects
Chonsut, P., Romyasamit, C., Konyanee, A., Niyomtham, N., Goodla, L., & Mordmuang, A. (2024) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/2024/5959077 · Cited by 16 · see citing works
The Ameliorative Impact of Centella asiatica on the Working Memory Deficit in Streptozotocin-induced Rat Model of Alzheimer Disease
Sahraei, R., Aminyavari, S., Hosseini, M., Hassanzadeh‐Taheri, M., Foadoddini, M., & Saebipour, M. R. (2021) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.2021.144.4 · Cited by 16 · see citing works
Centella asiatica Water Extract Shows Low Potential for Cytochrome P450–Mediated Drug Interactions
Wright, K. M., Magaña, A. A., Laethem, R. M., Moseley, C. L., Banks, T. T., Maier, C. S., Stevens, J. F., Quinn, J. F., & Soumyanath, A. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.090860 · Cited by 15 · see citing works
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Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration
Gray, N. E., Hack, W. R., Brandes, M. S., Zweig, J. A., Yang, L., Marney, L. C., Choi, J., Magaña, A. A., Cerruti, N., McFerrin, J., et al. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1357922 · Cited by 16 · see citing works
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Withania somnifera and Centella asiatica Extracts Ameliorate Behavioral Deficits in an In Vivo Drosophila melanogaster Model of Oxidative Stress
Cabey, K., Long, D. M., Law, A. D., Gray, N. E., McClure, C., Caruso, M. A., Lak, P., Wright, K. M., Stevens, J. F., Maier, C. S., et al. (2022) · Antioxidants · doi:10.3390/antiox11010121 · Cited by 13 · see citing works
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Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults
Wright, K. M., Bollen, M., David, J., Mepham, B., Magaña, A. A., McClure, C., Maier, C. S., Quinn, J. F., & Soumyanath, A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1228030 · Cited by 13 · see citing works
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Transthyretin Amyloidosis: Role of oxidative stress and the beneficial implications of antioxidants and nutraceutical supplementation
Eze, F. N. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105837 · Cited by 13 · see citing works
Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice
Varada, S., Chamberlin, S. R., Bui, L., Brandes, M. S., Gladen-Kolarsky, N., Harris, C., Hack, W. R., Neff, C. J., Brumbach, B. H., Soumyanath, A., et al. (2025) · Nutrients · doi:10.3390/nu17040729 · Cited by 11 · see citing works
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Neuroprotective effect of Mulmina™ against chemotherapy‑induced cognitive decline in normal rats
Kinra, M., Ranadive, N., Gourishetti, K., Nayak, P. G., Jagdale, R. N., Ahmed, S., Raghavendra, K., Mudgal, J., & Nandakumar, K. (2020) · Biomedical Reports · doi:10.3892/br.2020.1377 · Cited by 11 · see citing works
Immunomodulatory effect of standardized C. asiatica extract on a promotion of regulatory T cells in rats
Tawinwung, S., Junsaeng, D., Utthiya, S., & Khemawoot, P. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03394-z · Cited by 11 · see citing works
Centella asiatica enhances diabetic wound healing by decreasing macrophage-driven inflammation via the AKT/MAPK/NF-κB pathway
Xiao, F., Li, Q., Zeng, W., Tang, B., Chen, Q., Wu, C., Duan, Z., Chen, H., Rui, S., & Liu, B. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1632573 · Cited by 10 · see citing works
Centella asiatica lowers body fat accumulation via regulating cholesterol homeostasis- and lipid metabolism-related genes in mice with high-fat, high-sugar diet-induced obesity
Chang, Y. B., Ahn, Y., Seo, D.-B., Bae, S., Suh, H. J., Hong, Y. H., & Jung, E. Y. (2023) · Applied Biological Chemistry · doi:10.1186/s13765-023-00846-7 · Cited by 10 · see citing works
UHPLC–Q-ToF-MS-guided enrichment and purification of triterpenoids from Centella asiatica (L.) extract with macroporous resin
., A. I. C. D., Peter, G., Jude, S., Arundhathy, C. A., Jacob, J., Amalraj, A., Pius, A., & Gopi, S. (2017) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2017.1280681 · Cited by 10 · see citing works
Efficacy of a dietary supplement derived from five edible plants on telomere length in Thai adults: A randomized, double‐blind, placebo‐controlled trial
Praengam, K., Tuntipopipat, S., Muangnoi, C., Jangwangkorn, C., & Piamkulvanich, O. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.3851 · Cited by 12 · see citing works
Centella asiatica improves memory and executive function in middle-aged rats by controlling oxidative stress and cholinergic transmission
Firdaus, Z., Gutti, G., Ganeshpurkar, A., Kumar, A., Krishnamurthy, S., Singh, S. K., & Singh, T. D. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117888 · Cited by 9 · see citing works
Mechanistic role and potential of Ayurvedic herbs as anti-aging therapies
Raina, K., Kumari, R., Thakur, P., Sharma, R., Singh, R., Thakur, A., Anand, V., Sharma, R., & Chaudhary, A. (2023) · Drug Metabolism and Personalized Therapy · doi:10.1515/dmdi-2023-0024 · Cited by 27 · see citing works
Perspective: Council for Responsible Nutrition Science in Session. Optimizing Health with Nutrition—Opportunities, Gaps, and the Future
Ho, E., Drake, V., Michels, A. J., Nkrumah-Elie, Y. M., Brown, L. L., Scott, J. M., Newman, J. W. I., Shukitt‐Hale, B., Soumyanath, A., Chilton, F. H., et al. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.05.015 · Cited by 9 · see citing works
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Traditional knowledge of medicinal plants on Gau Island, Fiji: differences between sixteen villages with unique characteristics of cultural value
Miyamoto, K., Ehara, H., Thaman, R. R., Veitayaki, J., Yoshida, T., & Kobayashi, H. (2021) · Journal of Ethnobiology and Ethnomedicine · doi:10.1186/s13002-021-00481-w · Cited by 8 · see citing works
Autentikasi Centella asiatica (L.) Urb. (Pegagan) dan Adulterannya Berdasarkan Karakter Makroskopis, Mikroskopis, dan Profil Kimia
Maruzy, A., Budiarti, M., & Subositi, D. (2020) · Jurnal Kefarmasian Indonesia · doi:10.22435/jki.v10i1.1830 · Cited by 8 · see citing works
Centella asiatica, an Ayurvedic Medicinal Plant, Prevents the Major Neurodegenerative and Neurotoxic Mechanisms Associated with Cognitive Impairment
Ahuja, M., Patel, M., Majrashi, M., Mulabagal, V., & Dhanasekaran, M. (2017) · Medicinal and aromatic plants of the world · doi:10.1007/978-981-10-5978-0_1 · Cited by 9 · see citing works
Centella asiatica (Gotu kola) leaves
Thakurdesai, P. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00021-5 · Cited by 8 · see citing works
Lost in Translation? Finding Our Way To Effective Alzheimer’s Disease Therapies
Quinn, J. F. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179930 · Cited by 7 · see citing works
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Exploring the composition and properties of Centella asiatica metabolites and investigating their impact on BSA glycation, LDL oxidation and α-amylase inhibition
Borges, A. L. S., Bittar, V. P., Justino, A. B., Carrillo, M. S. P., Duarte, R. F. M., Silva, N. B. S., Gonçalves, D. S., Prado, D. G., Araújo, I. A. C., Martins, M. M., et al. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116143 · Cited by 6 · see citing works
Centella asiatica (L.) Urban. Attenuates Cell Damage in Hydrogen Peroxide-Induced Oxidative Stress in Transgenic Murine Embryonic Stem Cell Line-Derived Neural-Like Cells: A Preliminary Study for Potential Treatment of Alzheimer’s Disease
Mansor, N. I., Ling, K., Rosli, R., Hassan, Z., Adenan, M. I., & Nordin, N. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221233 · Cited by 6 · see citing works
Centella asiatica and its caffeoylquinic acid and triterpene constituents increase dendritic arborization of mouse primary hippocampal neurons and improve age-related locomotion deficits in Drosophila
Rowe, K., Gray, N. E., Zweig, J. A., Law, A. D., Techen, N., Maier, C. S., Soumyanath, A., & Kretzschmar, D. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1374905 · Cited by 6 · see citing works
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Use of medicinal plants for headache, and their potential implication in medication-overuse headache: Evidence from a population-based study in Nepal
Sørnes, E. Ø., Risal, A., Manandhar, K., Thomas, H., Steiner, T. J., & Linde, M. (2021) · Cephalalgia · doi:10.1177/0333102420970904 · Cited by 6 · see citing works
Sub-chronic oral toxicity of a water-soluble extract of Centella asiatica (Centell-S) in Wistar rats
Junsai, T., Tangpanithandee, S., Srimangkornkaew, P., Suknuntha, K., Vivithanaporn, P., & Khemawoot, P. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114509 · Cited by 5 · see citing works
In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide
Galla, R., Ferrari, S., Miletto, I., Mulè, S., & Uberti, F. (2025) · Foods · doi:10.3390/foods14152678 · Cited by 6 · see citing works
Phyto-nanotechnology: A novel beneficial strategy for Alzheimer's disease therapy
Ganguly, S. C., Sangram, S., Paul, S., & Kundu, M. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105868 · Cited by 5 · see citing works
A Critical Review Based on Preclinical Studies of Medicinal Plants for the Management of Alzheimer’s Disease
Wadhawan, S., Biswkarma, V. K., Chaudhary, A., & Masand, P. (2023) · Current Bioactive Compounds · doi:10.2174/1573407219666230807150426 · Cited by 4 · see citing works
Influence of short-term hypoxic exposure on spatial learning and memory function and brain-derived neurotrophic factor in rats—A practical implication to human's lost way
Kiuchi, M., Uno, T., Hasegawa, T., Koyama, K., & Horiuchi, M. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1330596 · Cited by 4 · see citing works
Brain and mental health in Ayurveda
Katiyar, C. K., Kanjilal, S., & Narwaria, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00007-0 · Cited by 4 · see citing works
A Multi-Center, Open-Label Exploratory Study to Assess Cognitive Function Response to Lifestyle Changes Plus Supplementation in Healthy Adults with Risk Factors Associated with Cognitive Decline
Lewis, E. D., Apostol, M., Langston, J., Parker, A., & Evans, M. (2023) · Applied Sciences · doi:10.3390/app13052818 · Cited by 4 · see citing works
Centella asiatica and protection in neurodevelopment
Bolumbu, G., & Mitha, K. V. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90052-2.00042-1 · Cited by 4 · see citing works
Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered
Speers, A. B., Wright, K. M., Brandes, M. S., Kedjejian, N. E., Matthews, D. G., Caruso, M. A., Harris, C., Koike, S., Nguyen, T. T. M., Quinn, J. F., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1277626 · Cited by 4 · see citing works
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A review on Centella asiatica (L.) nutrient and phytochemical composition and its potential neuroprotective effect in Alzheimer’s disease
Ganesan, V. K., Rajyalakshmi, R., Dabburu, K., Shanmugam, D. A. S., & Balaraman, A. D. (2025) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2025.100237 · Cited by 3 · see citing works
Medicinal Plants for Major Depressive Disorder
Bertollo, A. G., Spohr, L., BEARZI, A. E., Kreuz, K. M., & Ignácio, Z. M. (2026) · Brain Sciences · doi:10.3390/brainsci16020223 · Cited by 3 · see citing works
Phytochemical and Therapeutic Potential of Herbal Cognitive Enhancer
Bharti, A., Kashyap, K., Rutika, Moudgil, A., Bora, K. S., & Kumar, D. (2023) · Journal of Natural Remedies · doi:10.18311/jnr/2023/29946 · Cited by 3 · see citing works
Targeting angiogenesis, inflammation, and oxidative stress in Alzheimer's diseases
Bhandari, M., Tiwari, R. K., Chanda, S., & Bonde, G. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13587-3.00003-5 · Cited by 3 · see citing works
Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice
Matthews, D. G., Khorani, M., Bobe, G., Caruso, M. A., Magaña, A. A., Gray, N. E., Quinn, J. F., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2024) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823241296740 · Cited by 4 · see citing works
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Herbs for Attention-Deficit/Hyperactivity Disorder
Yarnell, E. L. (2018) · Alternative and Complementary Therapies · doi:10.1089/act.2018.29168.eya · Cited by 3 · see citing works
Centella asiatica ethanol extract increases hippocampal brain derived neurotrophic factor in male Wistar rats
Handayani, A., Yolanda, S., & Kodariah, R. (2018) · Universa Medicina · doi:10.18051/univmed.2018.v37.143-149 · Cited by 3 · see citing works
Ethnopharmacology, Phytochemistry, and Pharmacology of Ashtanga Ghrita: an Ayurvedic Polyherbal Formulation for Neurological Disorders
Singh, J., Singh, A., Sharma, V., Singh, T. D., Singh, M., Garg, R., Sharma, R., & Gautam, D. N. S. (2022) · Current Pharmacology Reports · doi:10.1007/s40495-022-00300-0 · Cited by 3 · see citing works
Factors Influencing Clinical Trials of Herbal Medicinal Products – Using Ginger as Example
Hook, I., Krenn, L., Steinhoff, B., & Wolfram, E. (2025) · Planta Medica · doi:10.1055/a-2686-6315 · Cited by 2 · see citing works
A standardized extract of Centella asiatica (ECa 233) alleviates brain injury and improves brain function in β-thalassemia mice with iron overload
Yatmark, P., Anutagerngkun, P., Huaijantug, S., Tantisira, M. H., Ngampramuan, S., Svasti, S., & Morales, N. P. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-05145-w · Cited by 2 · see citing works
Centella asiatica (L.) Urban (Apiaceae/Umbelliferae)
Akbar, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-16807-0_61 · Cited by 2 · see citing works
Ethanol Extract of Centella asiatica Improved Methamphetamine-Induced Neurotoxicity on Mouse Model via Stimulating Superoxide Dismutase II and microRNA-34A Expression
Shamsuddin, N., Zain, M. M., Adenan, M. I., & Noorden, M. S. A. (2023) · Sains Malaysiana · doi:10.17576/jsm-2023-5201-19 · Cited by 2 · see citing works
Natural products regulate mitochondrial function in cognitive dysfunction—A scoping review
Tuo, J., Peng, Y., Linghu, Y., Ming, T., Huang, S., & Xu, Z. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1091879 · Cited by 2 · see citing works
Preventive Role and Mechanism of Herbal Medicine in Alzheimer’s Disease with Special Reference to Phenolic Compounds
Bhakshu, L. M., Kamsala, R. V., & Venkataraju, R. R. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-8158-5_17 · Cited by 2 · see citing works
Centella asiatica promotes antioxidant gene expression and mitochondrial oxidative respiration in experimental autoimmune encephalomyelitisPreprint
Kundu, P., Yasuhara, K., Brandes, M. S., Zweig, J. A., Neff, C. J., Holden, S. J., Kessler, K., Matsumoto, S. G., Offner, H., Waslo, C. S., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3393042/v1 · Cited by 2 · see citing works
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Asiatic acid improves mitochondrial function, activates antioxidant response in the mouse brain and improves cognitive function in beta-amyloid overexpressing micePreprint
Varada, S., Chamberlin, S. R., Bui, L., Brandes, M. S., Gladen-Kolarsky, N., Harris, C., Hack, W. R., Brumbach, B. H., Quinn, J. F., & Gray, N. E. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.21.581270 · Cited by 2 · see citing works
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The effect of Centella asiatica ethanolic extract on liver superoxide dismutase and glutathione levels of aged Sprague-Dawley rats
Yusuf, M., Hermanadi, M. I., Rizqhilmi, M. F., Hakim, R. W., Farida, S. N., & Purwaningsih, E. H. (2022) · AIP conference proceedings · doi:10.1063/5.0100472 · Cited by 1 · see citing works
Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of Centella asiatica
Chamberlin, S. R., Zweig, J. A., Neff, C. J., Marney, L. C., Choi, J., Yang, L., Maier, C. S., Soumyanath, A., McWeeney, S. K., & Gray, N. E. (2024) · Pharmaceuticals · doi:10.3390/ph18010019 · Cited by 3 · see citing works
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Development of a Proton Spin Network Fingerprint Library to Support Mass Spectrometry-Based Identification of Pharmacophore-Bearing Constituents in the Botanical Supplement Centella asiatica
Neiheisel, S., Uchenik, D., Marney, L. C., Maier, C. S., Gray, N. E., Soumyanath, A., & Harinantenaina, L. (2025) · Journal of Natural Products · doi:10.1021/acs.jnatprod.4c01486 · Cited by 1 · see citing works
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Advances in Research on Tibetan Medicine for Improving Cognitive Dysfunction
Yu, T., Yu, Y., & Cheng, X. (2025) · International Journal of Drug Discovery and Pharmacology · doi:10.53941/ijddp.2025.100010 · Cited by 1 · see citing works
Centella asiatica improves sleep quality and quantity in aged mice
Dovek, L., Tinsley, C. E., Gutowsky, K., McDaniel, K. L., McGuire, N. M., Nungaray, L. R., Potter, Z., Ruffins, M., Milman, N., Wong, C., et al. (2025) · SLEEP Advances · doi:10.1093/sleepadvances/zpaf060 · Cited by 1 · see citing works
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Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats
Veerendra Kumar, M. H., & Gupta, Y. K. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00394-4 · Cited by 261 · see citing works
Centella asiatica improves synaptic plasticity and activates antioxidant and mitochondrial pathways in hippocampal neurons from an Alzheimer's disease mouse model
Gray, N., Zweig, J. A., Kawamoto, C., Quinn, J., & Soumyanath, A. (2016) · Planta Medica · doi:10.1055/s-0036-1596958 · Cited by 2 · see citing works
Self-citation
Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice
Gray, N. E., Zweig, J. A., Caruso, M., Martin, M. D., Zhu, J. Y., Quinn, J. F., & Soumyanath, A. (2018) · Brain and Behavior · doi:10.1002/brb3.1024 · Cited by 76 · see citing works
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Asiatic improves brain mitochondrial function, activates antioxidant response and attenuates cognitive deficits in beta amyloid overexpressing mice
Gray, N. E., Chamberlin, S. R., Bui, L., Brandes, M. S., Brumbach, B. H., & Quinn, J. F. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.062432 · Cited by 3 · see citing works
Self-citation
Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune EncephalomyelitisPreprint
Kundu, P., Yasuhara, K., Brandes, M. S., Zweig, J. A., Neff, C. J., Holden, S. J., Kessler, K., Matsumoto, S. G., Offner, H., Waslo, C. S., et al. (2023) · Preprints.org · doi:10.20944/preprints202309.0013.v1 · Cited by 1 · see citing works
Self-citation

Authors: Gray, N. E., Harris, C. J., Quinn, J. F., & Soumyanath, A.
Affiliations: Oregon Health & Science University (US)
Corresponding author: Gray, Nora E.
ORCID: Gray, Nora E.
Quinn, Joseph F.
Soumyanath, Amala
Venue: Journal of Ethnopharmacology
Publisher: Elsevier BV
Published: 2016-03
Volume: 180
Pages: 78-86
ISSN: 0378-8741 (ISSN-L)
DOI: 10.1016/j.jep.2016.01.013
PMC: PMC4764102
OpenAlex: W2272693890
Cited by: 123
References: 42
Citations by year: 2026: 5 · 2025: 14 · 2024: 22 · 2023: 17 · 2022: 7 · 2021: 13 · 2020: 16 · 2019: 10 · 2018: 11 · 2017: 8
FWCI: 19.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Ethnopharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIH-NCCAM (R01AT008099)
Oregon Alzheimer's Disease Center (OADC) (3P30-AG008017 24 S1)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords: Centella asiatica, cognitive enhancement, learning and memory, mitochondrial biogenesis, aging, hippocampus, frontal cortex, synaptic markers, brain gene expression, hepatic gene expression, aqueous extract, Ayurveda, traditional Chinese medicine
MeSH terms: Aging, Animals, Cerebellum, Cognition, Female, Frontal Lobe, Hippocampus, Liver, Male, Memory, Mice, Inbred C57BL, Mitochondria, Plant Extracts, Triterpenes, Gene Expression, Nootropic Agents, Maze Learning, Centella

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Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice

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