The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Effects of early-life stress on cognitive function and hippocampal structure in female rodents.
Open accessAbstract
We tested the effect of early-life stress (ELS) - 24h maternal deprivation (MD) at postnatal day (PND) 3 - on cognitive performance and hippocampal structure in 12-17-week-old female rats. Behavioral performance was examined in: the Elevated Plus Maze, as an index for general anxiety; the rodent Iowa gambling test, probing reward-based decision making; and the object recognition and object-in-location task, to assess non-stressful contextual memory performance. We further determined hippocampal dentate gyrus (DG) volume and cell density as well as adult proliferation and neurogenesis rates. Half of the rats was treated with the glucocorticoid receptor antagonist mifepristone during a critical pre-pubertal developmental window (PNDs 26-28), in an attempt to ameliorate the potentially adverse behavioral consequences of ELS. Neither MD nor treatment with the glucocorticoid antagonist affected behavioral performance of the females in any of the tasks. Also, DG structure, proliferation and neurogenesis were not different between the groups. Lack of structural differences and a behavioral phenotype in non-stressful hippocampus dependent learning tasks fits with the lack of phenotype generally reported after ELS in female but less so in male rodents. As evident from an extensive literature review, female and male animals appear to respond more similarly to early-life adversity when tested in anxiety-related tasks. This agrees with recent findings in humans suggesting that females may be relatively resilient to the structural/hippocampal effects of childhood maltreatment, but not to the anxiety and mood-related psychopathology for which childhood maltreatment is considered a risk factor.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Focusing on early postnatal manipulations of maternal care in rodents as a model for ELS, it seems that males are more affected than females in a broad range of behavioral domains (Loi et al., 2017; Schroeder et al., 2018).”
From Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood (2018) · cites this paper as Loi et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013
Steel, Z., Marnane, C., Iranpour, C., Chey, T., Jackson, J. W., Patel, V., & Silove, D. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu038 · Cited by 2,846
Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys
Kessler, R. C., McLaughlin, K. A., Green, J. G., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., Aguilar-Gaxiola, S., Alhamzawi, A. O., Alonso, J., Angermeyer, M., et al. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.110.080499 · Cited by 2,640
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Bailey, J. N. C., Bostrom, M. A., Rudock, M. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029202 · Cited by 1,811
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
Bevins, R. A., & Besheer, J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.205 · Cited by 1,278
Anxiety, defence and the elevated plus-maze.
Rodgers, R., & Dalvi, A. (1997) · Neuroscience and Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00058-9 · Cited by 1,028
Saxe, M. D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607207103 · Cited by 1,020
Do rats have a prefrontal cortex?
Uylings, H. B. M., Groenewegen, H. J., & Kolb, B. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.028 · Cited by 1,013
Cited by
Sorted by citations
Modulation of the Hypothalamic-Pituitary-Adrenal Axis by Early Life Stress Exposure
van Bodegom, M., Homberg, J. R., & Henckens, M. J. A. G. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00087 · Cited by 606
Walker, C., Bath, K. G., Joëls, M., Kőrösi, A., Larauche, M. H., Lucassen, P. J., Morris, M. J., Raineki, C., Roth, T. L., Sullivan, R. M., et al. (2017) · Stress · doi:10.1080/10253890.2017.1343296 · Cited by 432
Self-citationSex differences in hippocampal cognition and neurogenesis
Yagi, S., & Galea, L. A. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0208-4 · Cited by 371
Let’s call the whole thing off: evaluating gender and sex differences in executive function
Grissom, N. M., & Reyes, T. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0179-5 · Cited by 306
Stress, hypothalamic–pituitary–adrenal axis, hypothalamic–pituitary–gonadal axis, and aggression.
Mbiydzenyuy, N. E., & Qulu, L.-A. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01393-w · Cited by 255
Metadata
- Authors
- Loi, M., Mossink, J. C. L., Meerhoff, G. F., Den Blaauwen, J. L., Lucassen, P. J., & Joëls, M.
- Affiliations
- University Medical Center Utrecht (NL)
- University of Amsterdam (NL)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 342
- Pages
- 101-119
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1631193623
- Cited by
- 109
- References
- 121
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 10 · 2020: 15 · 2019: 23 · 2018: 12 · 2017: 9
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Dutch Ministry of Education, Culture, and Science
- NWO (024.001.003)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- early life stress, maternal deprivation, hippocampus, dentate gyrus, hippocampal neurogenesis, adult neurogenesis, mifepristone, glucocorticoid receptor, sex differences, anxiety, contextual memory, reward-based decision-making, child abuse, female rats
- MeSH terms
- Animals, Animals, Newborn, Anxiety, Cognition, Disease Models, Animal, Female, Gambling, Hippocampus, Hormone Antagonists, Maternal Deprivation, Memory, Neurons, Random Allocation, Receptors, Glucocorticoid, Sexual Maturation, Stress, Psychological, Mifepristone, Rats, Wistar, Treatment Failure, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
