Cited by 109Stress Responses and CortisolMemory and Neural MechanismsChild Abuse and Trauma

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Effects of early-life stress on cognitive function and hippocampal structure in female rodents.

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Loi, M., Mossink, J.C.L., Meerhoff, G.F., Den Blaauwen, J.L., Lucassen, P.J., Joëls, M.·2017·Neuroscience

DOI 10.1016/j.neuroscience.2015.08.024

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Abstract

We tested the effect of early-life stress (ELS) - 24h maternal deprivation (MD) at postnatal day (PND) 3 - on cognitive performance and hippocampal structure in 12-17-week-old female rats. Behavioral performance was examined in: the Elevated Plus Maze, as an index for general anxiety; the rodent Iowa gambling test, probing reward-based decision making; and the object recognition and object-in-location task, to assess non-stressful contextual memory performance. We further determined hippocampal dentate gyrus (DG) volume and cell density as well as adult proliferation and neurogenesis rates. Half of the rats was treated with the glucocorticoid receptor antagonist mifepristone during a critical pre-pubertal developmental window (PNDs 26-28), in an attempt to ameliorate the potentially adverse behavioral consequences of ELS. Neither MD nor treatment with the glucocorticoid antagonist affected behavioral performance of the females in any of the tasks. Also, DG structure, proliferation and neurogenesis were not different between the groups. Lack of structural differences and a behavioral phenotype in non-stressful hippocampus dependent learning tasks fits with the lack of phenotype generally reported after ELS in female but less so in male rodents. As evident from an extensive literature review, female and male animals appear to respond more similarly to early-life adversity when tested in anxiety-related tasks. This agrees with recent findings in humans suggesting that females may be relatively resilient to the structural/hippocampal effects of childhood maltreatment, but not to the anxiety and mood-related psychopathology for which childhood maltreatment is considered a risk factor.

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Authors: Loi, M., Mossink, J. C. L., Meerhoff, G. F., Den Blaauwen, J. L., Lucassen, P. J., & Joëls, M.
Affiliations: University Medical Center Utrecht (NL)
University of Amsterdam (NL)
ORCID: Den Blaauwen, J.L.
Lucassen, P.J.
Joëls, M.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2017-02
Volume: 342
Pages: 101-119
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2015.08.024
OpenAlex: W1631193623
Cited by: 109
References: 121
Citations by year: 2026: 6 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 10 · 2020: 15 · 2019: 23 · 2018: 12 · 2017: 9
FWCI: 4.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Utrecht University Repository (Utrecht University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Dutch Ministry of Education, Culture, and Science
NWO (024.001.003)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: early life stress, maternal deprivation, hippocampus, dentate gyrus, hippocampal neurogenesis, adult neurogenesis, mifepristone, glucocorticoid receptor, sex differences, anxiety, contextual memory, reward-based decision-making, child abuse, female rats
MeSH terms: Animals, Animals, Newborn, Anxiety, Cognition, Disease Models, Animal, Female, Gambling, Hippocampus, Hormone Antagonists, Maternal Deprivation, Memory, Neurons, Random Allocation, Receptors, Glucocorticoid, Sexual Maturation, Stress, Psychological, Mifepristone, Rats, Wistar, Treatment Failure, Neurogenesis

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Effects of early-life stress on cognitive function and hippocampal structure in female rodents.

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