Molecular imaging of the association between serotonin degeneration and beta-amyloid deposition in mild cognitive impairment
Open accessAbstract
BACKGROUND: Degeneration of the serotonin system has been observed in Alzheimer's disease (AD) and in mild cognitive impairment (MCI). In transgenic amyloid mouse models, serotonin degeneration is detected prior to widespread cortical beta-amyloid (Aβ) deposition, also suggesting that serotonin degeneration may be observed in preclinical AD. METHODS: The differences in the distribution of serotonin degeneration (reflected by the loss of the serotonin transporter, 5-HTT) relative to Aβ deposition was measured with positron emission tomography in a group of individuals with MCI and a group of healthy older adults. A multi-modal partial least squares (mmPLS) algorithm was applied to identify the spatial covariance pattern between 5-HTT availability and Aβ deposition. RESULTS: Forty-five individuals with MCI and 35 healthy older adults were studied, 22 and 27 of whom were included in the analyses who were "amyloid positive" and "amyloid negative", respectively. A pattern of lower cortical, subcortical and limbic 5-HTT availability and higher cortical Aβ deposition distinguished the MCI from the healthy older control participants. Greater expression of this pattern was correlated with greater deficits in memory and executive function in the MCI group, not in the control group. CONCLUSION: A spatial covariance pattern of lower 5-HTT availability and Aβ deposition was observed to a greater extent in an MCI group relative to a control group and was associated with cognitive impairment in the MCI group. The results support the application of mmPLS to understand the neurochemical changes associated with Aβ deposition in the course of preclinical AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Serotonergic dysfunction is implicated in Alzheimer's disease and Parkinson's disease progression, but probiotic interventions have shown inconsistent effects on serotonin levels in Parkinson's disease.
“In a recent randomized controlled trial (RCT), no significant changes in serum serotonin levels were observed following a 3-month adjunctive probiotic Bifidobacterium animalis subsp. lactis treatment in PD patients receiving conventional regimen (Benserazide and dopamine agonists).491 Furthermore, the administration of L. plantarum PS128 was ineffective in restoring MPTP-induced serotonin”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [474]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Desikan, R. S., Ségonne, F., Fischl, B., Quinn, B. T., Dickerson, B. C., Blacker, D., Buckner, R. L., Dale, A. M., Maguire, R. P., Hyman, B. T., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.021 · Cited by 13,324 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610 · see citing works
A fast diffeomorphic image registration algorithm
Ashburner, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.007 · Cited by 8,122 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496 · see citing works
Self-citationAutomated anatomical labelling atlas 3
Rolls, E. T., Huang, C., Lin, C., Feng, J., & Joliot, M. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116189 · Cited by 2,035 · see citing works
Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960 · see citing works
Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
Logan, J., Fowler, J. S., Volkow, N. D., Wang, G., Ding, Y., & Alexoff, D. L. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00008 · Cited by 1,515 · see citing works
Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R. W., Bullock, R., Love, S., Neal, J. W., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61075-2 · Cited by 1,416 · see citing works
Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366 · see citing works
Self-citationKatzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
The spectrum of behaviors influenced by serotonin
Lucki, I. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00139-5 · Cited by 1,154 · see citing works
Jack, C. R., Lowe, V. J., Weigand, S. D., Wiste, H. J., Senjem, M. L., Knopman, D. S., Shiung, M. M., Gunter, J. L., Boeve, B. F., Kemp, B. J., et al. (2009) · Brain · doi:10.1093/brain/awp062 · Cited by 1,099 · see citing works
BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942 · see citing works
(2001) · PubMed · Cited by 780 · see citing works
Benedict, R. H. B., Schretlen, D. J., Groninger, L. D., Dobraski, M., & Shpritz, B. (1996) · Psychological Assessment · doi:10.1037/1040-3590.8.2.145 · Cited by 735 · see citing works
Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease
Brier, M. R., Gordon, B., Friedrichsen, K., McCarthy, J., Stern, A., Christensen, J., Owen, C., Aldea, P., Su, Y., Hassenstab, J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2362 · Cited by 734 · see citing works
Self-citationAdvanced Maillard reaction end products are associated with Alzheimer disease pathology.
Smith, M. A., Taneda, S., Richey, P. L., Miyata, S., Yan, S. D., Stern, D., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5710 · Cited by 715 · see citing works
Rolls, E. T., Joliot, M., & Tzourio‐Mazoyer, N. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.07.075 · Cited by 686 · see citing works
Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjects
Mormino, E. C., Kluth, J. T., Madison, C. M., Rabinovici, G. D., Baker, S. L., Miller, B. L., Koeppe, R. A., Mathis, C. A., Weiner, M. W., Jagust, W. J., et al. (2009) · Brain · doi:10.1093/brain/awn320 · Cited by 684 · see citing works
Prevalence of Amyloid PET Positivity in Dementia Syndromes: A Meta-analysis
Ossenkoppele, R., Jansen, W. J., Rabinovici, G. D., Knol, D. L., van der Flier, W. M., van Berckel, B. N. M., Scheltens, P., Visser, P. J., Verfaillie, S. C. J., Zwan, M. D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4669 · Cited by 677 · see citing works
Ichise, M., Liow, J., Lu, J., Takano, A., Modell, K. J., Toyama, H., Suhara, T., Suzuki, K., Innis, R. B., & Carson, R. E. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000085441.37552.ca · Cited by 651 · see citing works
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
Engler, H., Forsberg, A., Almkvist, O., Blomquist, G., Larsson, E., Savitcheva, I., Wall, A. E., Ringheim, A., Långström, B., & Nordberg, A. K. (2006) · Brain · doi:10.1093/brain/awl178 · Cited by 614 · see citing works
Bowen, D. M., Allen, S. J., Benton, J. S., Goodhardt, M., Haan, E., Palmer, A. M., Sims, N. R., Smith, C., Spillane, J. A., Esiri, M. M., et al. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb11838.x · Cited by 443 · see citing works
First, M. B., Spitzer, R. L., Gibbon, M., Williams, J. B. W., Davies, M., Borus, J. F., Howes, M. J., Kane, J. M., Pope, H. G., & Rounsaville, B. J. (1995) · Journal of Personality Disorders · doi:10.1521/pedi.1995.9.2.92 · Cited by 420 · see citing works
Villeneuve, S., Rabinovici, G. D., Cohn-Sheehy, B. I., Madison, C., Ayakta, N., Ghosh, P. M., La Joie, R., Arthur-Bentil, S. K., Vogel, J. W., Marks, S. M., et al. (2015) · Brain · doi:10.1093/brain/awv112 · Cited by 408 · see citing works
Molliver, M. E. (1987) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198712001-00002 · Cited by 347 · see citing works
Neuronal expression of myeloperoxidase is increased in Alzheimer's disease
Green, P. S., Mendez, A. J., Jacob, J. S., Crowley, J. R., Growdon, W., Hyman, B. T., & Heinecke, J. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02527.x · Cited by 332 · see citing works
Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain.
Varnäs, K., Halldin, C., & Hall, H. (2004) · Human Brain Mapping · doi:10.1002/hbm.20035 · Cited by 332 · see citing works
A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory
King, M. V., Marsden, C. A., & Fone, K. C. F. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.07.001 · Cited by 305 · see citing works
Aminergic systems in Alzheimer's disease and Parkinson's disease
D’Amato, R. J., Zweig, R. M., Whitehouse, P. J., Wenk, G. L., Singer, H. S., Mayeux, R. P., Price, D. L., & Snyder, S. H. (1987) · Annals of Neurology · doi:10.1002/ana.410220207 · Cited by 248 · see citing works
Grinberg, L. T., Rüb, U., Ferretti, R. E. L., Nitríni, R., Farfel, J. M., Polichiso, L., Gierga, K., Jacob‐Filho, W., Heinsen, H., & Brazilian Brain Bank Study Group (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.00997.x · Cited by 244 · see citing works
Serotonin 1A receptors in the living brain of Alzheimer's disease patients
Kepe, V., Barrio, J. R., Huang, S., Ercoli, L. M., Siddarth, P., Shoghi, K. I., Cole, G. M., Satyamurthy, N., Cummings, J. L., Small, G. W., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510237103 · Cited by 241 · see citing works
Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis
Lyness, S. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00057-x · Cited by 240 · see citing works
Nucleus Raphe Dorsalis in Dementia of the Alzheimer Type
Curcio, C. A., & Kemper, T. L. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198407000-00001 · Cited by 225 · see citing works
Amyloid Imaging in Aging and Dementia: Testing the Amyloid HypothesisIn Vivo
Rabinovici, G. D., & Jagust, W. J. (2009) · Behavioural Neurology · doi:10.1155/2009/609839 · Cited by 224 · see citing works
Smith, M. A., Sayre, L. M., Anderson, V. E., Harris, P. L. R., Beal, M. F., Kowall, N. W., & Perry, G. L. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804600605 · Cited by 222 · see citing works
Wu, W., Nicolazzo, J. A., Wen, L., Chung, R. S., Stankovic, R. K., Bao, S., Lim, C. K., Brew, B. J., Cullen, K. M., & Guillemin, G. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059749 · Cited by 208 · see citing works
Liu, Y., Yoo, M.-J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E., & Lee, M. K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4218-08.2008 · Cited by 206 · see citing works
Self-citationDoes Alzheimer's disease begin in the brainstem?
Simic, G., Stanic, G., Mladinov, M., Jovanov‐Milosevic, N., Kostovic, I., & Hof, P. R. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01038.x · Cited by 204 · see citing works
Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo.
Rabinovici, G. D., & Jagust, W. J. (2009) · PubMed Central · doi:10.3233/ben-2009-0232 · Cited by 194 · see citing works
NELSON, R., GUO, Z., HALAGAPPA, V, PEARSON, M., GRAY, A., MATSUOKA, Y., BROWN, M., MARTIN, B., IYUN, T., & MAUDSLEY, S. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.01.037 · Cited by 173 · see citing works
Loss of brain 5-HT2receptors in Alzheimer's disease
Blin, J., Baron, J., Dubois, B., et al. (1993) · Brain · doi:10.1093/brain/116.3.497 · Cited by 172 · see citing works
Steinbusch, H. W. M., Nieuwenhuys, R., Verhofstad, A. A. J., & Van der Kooy, D. (1981) · PubMed · Cited by 165 · see citing works
Wilson, A. A., Ginovart, N., Hussey, D. F., Meyer, J., & Houle, S. (2002) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(02)00316-5 · Cited by 157 · see citing works
Garcı́a-Alloza, M., Hirst, W. D., Chen, C., Lasheras, B., Francis, P. T., & Ramírez, M. J. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300330 · Cited by 151 · see citing works
Statistical dynamic image reconstruction in state-of-the-art high-resolution PET
Rahmim, A., Cheng, J.-C. K., Blinder, S. A. L., Camborde, M.-L., & Sossi, V. (2005) · Physics in Medicine and Biology · doi:10.1088/0031-9155/50/20/010 · Cited by 136 · see citing works
Serotonin nerve cells in Alzheimer's disease.
Mann, D., & Yates, P. O. (1983) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.46.1.96 · Cited by 135 · see citing works
The evolution of Alzheimer's disease‐related cytoskeletal pathology in the human raphe nuclei
Rüb, U., Tredici, K. D., Schultz, C., Thal, D. R., Braak, E., & Braak, H. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2000.00291.x · Cited by 134 · see citing works
Reduced 5-HT2A receptor binding in patients with mild cognitive impairment
Hasselbalch, S. G., Madsen, K., Svarer, C., Pinborg, L. H., Holm, S., Paulson, O. B., Waldemar, G., & Knudsen, G. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.011 · Cited by 122 · see citing works
Parsey, R. V., KENT, J. M., Oquendo, M. A., Richards, M., Pratap, M., Cooper, T. B., Arango, V., & Mann, J. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.010 · Cited by 119 · see citing works
Cho, S., & Hu, Y. F. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.07.021 · Cited by 114 · see citing works
Is amyloid-β harmful to the brain? Insights from human imaging studies
Jagust, W. (2016) · Brain · doi:10.1093/brain/awv326 · Cited by 110 · see citing works
Christensen, R., Marcussen, A. B., Wörtwein, G., Knudsen, G. M., & Aznar, S. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.10.009 · Cited by 109 · see citing works
The Second Generation HRRT - a Multi Centre Scanner Performance Investigation
Sossi, V., de Jong, H. W. A. M., Barker, W. C., Bloomfield, P. M., Burbar, Z., Camborde, M.-L., Comtat, C., Eriksson, L. A., Houle, S., Keator, D. B., et al. (2006) · IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) · doi:10.1109/nssmic.2005.1596770 · Cited by 104 · see citing works
Invernizzi, R. W., Velasco, C., Bramante, M., LONGO, A., & SAMANIN, R. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00060-9 · Cited by 102 · see citing works
Wilson, A. A., García, A., Chestakova, A., et al. (2004) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.854 · Cited by 102 · see citing works
Molecular imaging of serotonin degeneration in mild cognitive impairment
Smith, G. S., Barrett, F. S., Joo, J. H., Nassery, N., Savonenko, A. V., Sodums, D. J., Marano, C. M., Munro, C. A., Brandt, J., Kraut, M. A., et al. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.05.007 · Cited by 102 · see citing works
Self-citationSerotonergic Therapies for Cognitive Symptoms in Alzheimer’s Disease: Rationale and Current Status
Ramírez, M. J., Lai, M. K. P., Tordera, R. M., & Francis, P. T. (2014) · Drugs · doi:10.1007/s40265-014-0217-5 · Cited by 92 · see citing works
Altered Brain Serotonin Transporter and Associated Glucose Metabolism in Alzheimer Disease
Ouchi, Y., Yoshikawa, E., Futatsubashi, M., Yagi, S., Ueki, T., & Nakamura, K. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.063008 · Cited by 83 · see citing works
Rüb, U., Stratmann, K., Heinsen, H., Turco, D. D., Seidel, K., den Dunnen, W. F. A., & Korf, H. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160606100509 · Cited by 81 · see citing works
Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment
Truchot, L., Costes, N., Zimmer, L., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000271377.52421.4a · Cited by 75 · see citing works
Insel, P. S., Ossenkoppele, R., Gessert, D., Jagust, W., Landau, S. M., Hansson, O., Weiner, M. W., & Mattsson, N. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00281 · Cited by 75 · see citing works
Geldenhuys, W. J., & der Schyf, C. J. V. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.51 · Cited by 73 · see citing works
Cerebral Serotonin 4 Receptors and Amyloid-β in Early Alzheimer's Disease
Madsen, K., Neumann, W., Holst, K. K., Marner, L., Haahr, M. E., Lehel, S., Knudsen, G. M., & Hasselbalch, S. G. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110056 · Cited by 72 · see citing works
Chen, K., Reiman, E. M., Huan, Z., Caselli, R. J., Bandy, D. J., Ayutyanont, N., & Alexander, G. E. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.053 · Cited by 69 · see citing works
Self-citationApolipoprotein E allele distribution in parents of Down's syndrome children
Avramopoulos, D., Grigoriadou, M., Petersen, M. B., Mikkelsen, M., Petersen, M. B., & Vassilopoulos, D. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91346-x · Cited by 68 · see citing works
Self-citationGołembiowska, K., & Dziubina, A. (2001) · PubMed · Cited by 65 · see citing works
Dystrophic serotonergic axons in neurodegenerative diseases
Azmitia, E. C., & Nixon, R. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.060 · Cited by 63 · see citing works
Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model
Cirrito, J. R., Wallace, C. E., Yan, P., Davis, T. A., Gardiner, W. D., Doherty, B. M., King, D., Yuede, C. M., Lee, J.-M., & Sheline, Y. (2020) · Neurology · doi:10.1212/wnl.0000000000010733 · Cited by 61 · see citing works
Lucas, G., Deurwaerdère, P. D., Porras, G., & Spampinato, U. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00020-4 · Cited by 54 · see citing works
Cadet, J. L. (1988) · Medical Hypotheses · doi:10.1016/0306-9877(88)90085-0 · Cited by 48 · see citing works
Ramos‐Rodríguez, J. J., Gil, S. M., Rey-Brea, R., Berrocoso, E., & Garcı́a-Alloza, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079947 · Cited by 47 · see citing works
Lucas, G., Du, J., Romeas, T., Mnie‐Filali, O., Haddjeri, N., Piñeyro, G., & Debonnel, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009253 · Cited by 47 · see citing works
Apathy and Executive Function in Depressed Elderly
Marin, R. S., Butters, M. A., Mulsant, B. H., Pollock, B. G., & Reynolds, C. F. (2003) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988703016002009 · Cited by 47 · see citing works
Metaxas, A., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M., & Finsen, B. R. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0491-2 · Cited by 42 · see citing works
Effect of escitalopram dose and treatment duration on CSF Aβ levels in healthy older adults
Sheline, Y. I., Snider, B. J., Beer, J. C., Seok, D., Fagan, A., Suckow, R., Lee, J.-M., Waligórska, T., Korecka, M., Aselcioglu, I., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000010725 · Cited by 41 · see citing works
Chen, K., Ayutyanont, N., Langbaum, J. B. S., Fleisher, A., Reschke, C., Lee, W., Liu, X., Alexander, G. E., Bandy, D., Caselli, R. J., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.005 · Cited by 39 · see citing works
Self-citationMateo, Y., Ruíz-Ortega, J. Á., Pineda, J., et al. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00041-1 · Cited by 39 · see citing works
Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease
Hirao, K., Pontone, G. M., & Smith, G. S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.010 · Cited by 37 · see citing works
Self-citationWilson, A. A., Sadovski, O., Nóbrega, J. N., Raymond, R., Bambico, F. R., Nashed, M. G., García, A., Bloomfield, P. M., Houle, S., Mizrahi, R., et al. (2017) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2017.05.011 · Cited by 34 · see citing works
Smith, G. S., Workman, C. I., Protas, H. D., Su, Y., Savonenko, A. V., Kuwabara, H., Gould, N. F., Kraut, M. A., Joo, J. H., Nandi, A., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01539-9 · Cited by 29 · see citing works
Self-citationMarner, L., Knudsen, G. M., Madsen, K., Holm, S., Baaré, W. F. C., & Hasselbalch, S. G. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100903 · Cited by 25 · see citing works
Molecular imaging of beta-amyloid deposition in late-life depression
Smith, G. S., Kuwabara, H., Nandi, A., Gould, N. F., Nassery, N., Savonenko, A. V., Joo, J. H., Kraut, M. A., Brašić, J. R., Holt, D. P., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.002 · Cited by 25 · see citing works
Self-citationCerebral Amyloid Deposition and Serotoninergic Innervation in Parkinson Disease
Kotagal, V., Bohnen, N. I., Müller, M. L. T. M., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.764 · Cited by 21 · see citing works
Distinct Functional Effects of Human 5-HT4 Receptor Isoforms on β-Amyloid Secretion
Robert, S. J., & Lezoualc’h, F. (2008) · Neurodegenerative Diseases · doi:10.1159/000113691 · Cited by 21 · see citing works
Frameworking memory and serotonergic markers
Meneses, A. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0079 · Cited by 19 · see citing works
Serotonergic modulation of hippocampal acetylcholine release after long-term neuronal grafting
Hilgert, M., Buchholzer, M.-L., Jeltsch‐David, H., et al. (2000) · Neuroreport · doi:10.1097/00001756-200009280-00006 · Cited by 18 · see citing works
5-HT1B and other related serotonergic proteins are altered in APPswe mutation
Tajeddinn, W., Persson, T., Maioli, S., Calvo‐Garrido, J., Parrado‐Fernández, C., Yoshitake, T., Kehr, J., Francis, P. T., Winblad, B. G., Höglund, K., et al. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.03.064 · Cited by 18 · see citing works
Liu, Y. M., Lee, M. K., James, M. M., Price, D. L., Borchelt, D., Troncoso, J. C., & Oh, E. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101602 · Cited by 16 · see citing works
Smith, G. S., Kuwabara, H., Gould, N. F., Nassery, N., Savonenko, A. V., Joo, J. H., Bigos, K. L., Kraut, M. A., Brašić, J. R., Holt, D. P., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108447 · Cited by 15 · see citing works
Self-citationCitalopram for the Treatment of Agitation in Alzheimer Dementia
Peters, M. E., Vaidya, V., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S. S., Shade, D. M., et al. (2015) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988715601735 · Cited by 10 · see citing works
Self-citationQiao, Z., Mardon, K., Stimson, D. H. R., et al. (2019) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2019.12.007 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Delis D.C. Kaplan E. Kramer J.H. Delis Kaplan Executive Function System (D-KEFS) Test Review Applied 2006 Neuropsychology
- Delis D. Kramer J. Kaplan E. Ober B. California Verbal Learning Test (CVLT) Manual The Psychological Corporation 1987 10.1207/s15328023top2503_18 · DOI
Cited by
Sorted by citations
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
- Authors
- Smith, G. S., Protas, H., Kuwabara, H., Savonenko, A., Nassery, N., Gould, N. F., Kraut, M., Avramopoulos, D., Holt, D., Dannals, R. F., Nandi, A., Su, Y., Reiman, E. M., & Chen, K.
- Affiliations
- Johns Hopkins University (US)
- Banner Alzheimer’s Institute (US)
- Corresponding author
- Smith, Gwenn S.
- ORCID
- Venue
- NeuroImage: Clinical
- Publisher
- Elsevier BV
- Published
- 2023
- Volume
- 37
- Pages
- 103322
- ISSN
- 2213-1582 (ISSN-L)
- PMC
- PMC9869478
- OpenAlex
- W4313597924
- Cited by
- 22
- References
- 101
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 5 · 2023: 5
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- NeuroImage Clinical (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (AG038893, AG041633, AG059390, MH064823, MH086881, P30 AG072980, UL1 TR 001079)
- Arizona State University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- serotonin transporter, amyloid-beta deposition, mild cognitive impairment, Alzheimer's disease, preclinical Alzheimer's disease, amyloid PET, memory impairment, executive dysfunction
- MeSH terms
- Alzheimer Disease, Animals, Serotonin, Amyloid beta-Peptides, Positron-Emission Tomography, Mice, Molecular Imaging, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
