Is N2O3 the main nitrosating intermediate in aerated nitric oxide (NO) solutions in vivo? If so, where, when, and which one?
Abstract
The widespread opinion that N 2 O 3 as a product of NO oxidation is the only nitros(yl)ating agent under aerobic conditions is based on experiments in homogeneous buffered water solutions. In vivo NO is oxidized in heterogeneous media and this opinion is not correct. The equilibrium in the system being dependent on temperature and Δ G(sol) for NO, NO 2, isomers of both N 2 O 3, and N 2 O 4. For polar solvents including water, Δ G(sol) for N 2 O 3 is high enough, and a stationary concentration of N 2 O 3 in the mixture with other oxides is sufficient to guarantee the hydrolysis of N 2 O 3 to nitrite. In heterogeneous media, the mixture contains solvates NO 2(sol), N 2 O 3(sol), and N 2 O 4(sol) at stationary nonequilibrium concentrations. As far as Δ G(sol) is decreased in heterogeneous mixtures with low polar solvents and/or at increased temperatures, the equilibrium in such a system shifts to NO 2. Although NO 2 is a reactive free radical, it almost does not react with water. In contrast, the reaction with most functional protein groups efficiently proceeds by a radical type with the formation of nitrite and new radicals (X) further stabilized in various forms. Therefore, the ratio of the nitrosylated and nitrated products yields depends on actual concentrations of all NOx. © 2002 Wiley Periodicals, Inc. J Biochem Mol Toxicol 16:109–120, 2002. DOI 10.1002/jbt.10029
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Dinitrogen trioxide (N2O3) is a strong nitrosating species also formed in the oxidation of NO.
“Dinitrogen trioxide (N2O3) is a strong nitrosating species also formed in the oxidation of NO (Eq. 29) (691, 692, 1018).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [691]
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- Authors
- Nedospasov, A. A.
- Affiliations
- Institute of Molecular Genetics (RU)
- Corresponding author
- Nedospasov, Andrei A.
- Venue
- Journal of Biochemical and Molecular Toxicology
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 16
- Issue
- 3
- Pages
- 109-120
- ISSN
- 0887-2082 (ISSN-L)
- 1095-6670
- 1099-0461
- OpenAlex
- W2044990762
- Cited by
- 38
- References
- 69
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biochemical and Molecular Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- nitrous oxide, NO oxidation, nitrosating agents, nitrite production, nitration, nitrogen dioxide, dinitrogen tetroxide, solvation free energy, heterogeneous media, protein nitrosylation, nitrosyl radicals
- MeSH terms
- Animals, Free Radicals, Humans, Kinetics, Micelles, Nitric Oxide, Nitrogen Oxides, Oxidation-Reduction, Proteins, RNA, Thermodynamics, Water, Nitrosation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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