Effects of acute supplementation of L-arginine and nitrate on endurance and sprint performance in elite athletes
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This study examined the effects of acute supplementation with L-arginine and nitrate on running economy, endurance and sprint performance in endurance-trained athletes. In a randomised cross-over, double-blinded design we compared the effects of combined supplementation with 6 g L-arginine and 614 mg nitrate against 614 mg nitrate alone and placebo in nine male elite cross-country skiers (age 18 ± 0 years, VO2max 69.3 ± 5.8 ml ⋅ min(-1) ⋅ kg(-1)). After a 48-hour standardisation of nutrition and exercise the athletes were tested for plasma nitrate and nitrite concentrations, blood pressure, submaximal running economy at 10 km ⋅ h(-1) and 14 km ⋅ h(-1) at 1% incline and 180 m as well as 5-km time-trial running performances. Plasma nitrite concentration following L-arginine + nitrate supplementation (319 ± 54 nmol ⋅ L(-1)) did not differ from nitrate alone (328 ± 107 nmol ⋅ L(-1)), and both were higher than placebo (149 ± 64 nmol ⋅ L(-1), p < 0.01). There were no differences in physiological responses during submaximal running or in 5-km performance between treatments. The plasma nitrite concentrations indicate greater nitric oxide availability both following acute supplementation of L-arginine + nitrate and with nitrate alone compared to placebo, but no additional effect was revealed when L-arginine was added to nitrate. Still, there were no effects of supplementation on exercise economy or endurance running performance in endurance-trained cross-country skiers.
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Several other studies have failed to positively report on the ability of arginine to operate as an ergogenic aid.
“In accordance, several other studies have failed to positively report on the ability of arginine to operate as an ergogenic aid [278, 640–644].”
From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [643]
An acute high nitrate dose (~10 mmol) did not alter 180-m sprint running performance compared to placebo in junior elite cross-country skiers.
“Furthermore, an acute, high NO 3 -dose (∼10 mmol) did not alter 180-m sprint running performance compared to placebo in junior elite cross-country skiers (131).”
From Dietary Nitrate and Physical Performance (2018) · cites this paper as [131]
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- Authors
- Sandbakk, S. B., Sandbakk, Ø., Peacock, O., James, P., Welde, B., Stokes, K., Böhlke, N., & Tjønna, A. E.
- Affiliations
- Norwegian University of Science and Technology (NO)
- University of Bath (GB)
- Cardiff University (GB)
- Høgskolen i Nord-Trøndelag (NO)
- United Kingdom Sport (GB)
- Corresponding author
- Tjønna, Arnt Erik
- ORCID
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 48
- Pages
- 10-15
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W2003103942
- Cited by
- 66
- References
- 47
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 10 · 2019: 3 · 2018: 6 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 1 · 2013: 1
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- The University of Bath Online Publications Store (The University of Bath) (submittedVersion)
- Pure (University of Bath) (submittedVersion, other-oa)
- Funders
- The Norwegian University of Science and Technology
- UK Sport Council
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- L-arginine, dietary nitrate, acute supplementation, endurance performance, sprint performance, running economy, cross-country skiing, plasma nitrite, nitric oxide bioavailability, elite athletes
- MeSH terms
- Adolescent, Arginine, Blood Pressure, Double-Blind Method, Humans, Male, Nitrates, Nitric Oxide, Nitrites, Running, Dietary Supplements, Athletic Performance, Athletes
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