Commentaries on Viewpoint: Can elite athletes benefit from dietary nitrate supplementation?

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · see citing works

Physiology of Nitric Oxide in Skeletal Muscle

Stamler, J. S., & Meissner, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.209 · Cited by 1,080 · see citing works

Effect of exercise training on endothelium‐derived nitric oxide function in humans

Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068197 · Cited by 1,040 · see citing works

Sample Size Estimation: How Many Individuals Should Be Studied?

Eng, J. (2003) · Radiology · doi:10.1148/radiol.2272012051 · Cited by 811 · see citing works

Aging and vascular endothelial function in humans

Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725 · see citing works

Nitric oxide and neurally mediated regulation of skin blood flow during local heating

Minson, C. T., Berry, L. T., & Joyner, M. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.4.1619 · Cited by 699 · see citing works

Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans

Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689 · see citing works

Effects of dietary nitrate on oxygen cost during exercise

Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · see citing works

Influence of dietary nitrate on nitrite content of human saliva: Possible relevance to in vivo formation of N-nitroso compounds

Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596 · see citing works

Dietary Nitrate Supplementation and Exercise Performance

Jones, A. M. (2014) · Sports Medicine · doi:10.1007/s40279-014-0149-y · Cited by 442 · see citing works

Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats

Ferguson, S. K., Hirai, D. M., Copp, S. W., Holdsworth, C. T., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.243121 · Cited by 333 · see citing works

Dietary nitrate increases tetanic [Ca²⁺]_i and contractile force in mouse fast‐twitch muscle

Hernández, A., Schiffer, T. A., Ivarsson, N., Cheng, A. J., Bruton, J. D., Lundberg, J. O., Weitzberg, E., & Westerblad, H. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.232777 · Cited by 319 · see citing works

Significant Molecular and Systemic Adaptations after Repeated Sprint Training in Hypoxia

Faiss, R., Léger, B., Vésin, J.-M., Fournier, P.-E., Eggel, Y., Dériaz, O., & Millet, G. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056522 · Cited by 295 · see citing works

Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia

Vanhatalo, A., Fulford, J., Bailey, S. J., Blackwell, J. R., Winyard, P. G., & Jones, A. M. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.216341 · Cited by 233 · see citing works

Effects of short-term dietary nitrate supplementation on blood pressure, O₂uptake kinetics, and muscle and cognitive function in older adults

Kelly, J., Fulford, J., Vanhatalo, A., Blackwell, J. R., French, O., Bailey, S. J., Gilchrist, M., Winyard, P. G., & Jones, A. M. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00406.2012 · Cited by 232 · see citing works

The Effect of Nitric-Oxide-Related Supplements on Human Performance

Bescós, R., Sureda, A., Tur, J. A., & Pons, A. (2012) · Sports Medicine · doi:10.2165/11596860-000000000-00000 · Cited by 231 · see citing works

Influence of acute dietary nitrate supplementation on 50 mile time trial performance in well-trained cyclists

Wilkerson, D. P., Hayward, G. M., Bailey, S. J., Vanhatalo, A., Blackwell, J. R., & Jones, A. M. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2397-6 · Cited by 229 · see citing works

Control of microvascular oxygen pressures in rat muscles comprised of different fibre types

McDonough, P., Behnke, B. J., Padilla, D. J., Musch, T. I., & Poole, D. C. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.079533 · Cited by 228 · see citing works

Brachial Artery Blood Flow Responses to Different Modalities of Lower Limb Exercise

Thijssen, D. H. J., Dawson, E. A., Black, M. A., Hopman, M. T. E., Cable, N. T., & GREEN, D. J. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181923957 · Cited by 201 · see citing works

Aerobic Fitness Affects the Exercise Performance Responses to Nitrate Supplementation

PORCELLI, S., RAMAGLIA, M., BELLISTRI, G., PAVEI, G., PUGLIESE, L., MONTORSI, M., RASICA, L., & MARZORATI, M. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000577 · Cited by 187 · see citing works

Cardiac output and leg and arm blood flow during incremental exercise to exhaustion on the cycle ergometer

Calbet, J. A. L., González‐Alonso, J., Helge, J. W., Søndergaard, H., Munch‐Andersen, T., Boushel, R., & Saltin, B. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01281.2006 · Cited by 174 · see citing works

The Effect of Nitrate Supplementation on Exercise Performance in Healthy Individuals: A Systematic Review and Meta-Analysis

Hoon, M. W., Johnson, N. A., Chapman, P., & Burke, L. M. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.5.522 · Cited by 157 · see citing works

Beetroot juice supplementation speeds O2uptake kinetics and improves exercise tolerance during severe-intensity exercise initiated from an elevated metabolic rate

Breese, B. C., McNarry, M. A., Marwood, S., Blackwell, J. R., Bailey, S. J., & JONES, A. M. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00295.2013 · Cited by 155 · see citing works

Nitric oxide in adaptation to altitude

Beall, C. M., Laskowski, D. M., & ERZURUM, S. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.028 · Cited by 146 · see citing works

Beetroot Juice Supplementation Does Not Improve Performance of Elite 1500-m Runners

BOORSMA, R. K., WHITFIELD, J., & SPRIET, L. L. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000364 · Cited by 142 · see citing works

Ventilation, Oxidative Stress, and Nitric Oxide in Hypobaric versus Normobaric Hypoxia

Faiss, R., Pialoux, V., Sartori, C. S., Faës, C., Dériaz, O., & Millet, G. P. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31826d5aa2 · Cited by 139 · see citing works

Influence of nitrate supplementation on <scp>VO₂</scp> kinetics and endurance of elite cyclists

Christensen, P. M., Nyberg, M., & Bangsbo, J. (2013) · Scandinavian Journal of Medicine &amp; Science in Sports · doi:10.1111/sms.12005 · Cited by 138 · see citing works

Effects of prolonged oral supplementation with l ‐arginine on blood pressure and nitric oxide synthesis in preeclampsia

Rytlewski, K., Olszanecki, R., Korbut, R., & Zdebski, Z. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01445.x · Cited by 132 · see citing works

Breaking the matches in a paired t‐test for community interventions when the number of pairs is small

Diehr, P. H., Martin, D. C., Koepsell, T. D., & Cheadle, A. D. (1995) · Statistics in Medicine · doi:10.1002/sim.4780141309 · Cited by 131 · see citing works

Dietary Nitrate Does Not Enhance Running Performance in Elite Cross-Country Skiers

PEACOCK, O., TJØNNA, A. E., JAMES, P., WISLØFF, U., WELDE, B., BÖHLKE, N., SMITH, A., STOKES, K., COOK, C., & SANDBAKK, Ø. (2012) · Medicine &amp; Science in Sports &amp; Exercise · doi:10.1249/mss.0b013e3182640f48 · Cited by 126 · see citing works

Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health

Kapil, V., Weitzberg, E., Lundberg, J. O., & Ahluwalia, A. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.03.162 · Cited by 126 · see citing works

The Effect of Variable Doses of Inorganic Nitrate-Rich Beetroot Juice on Simulated 2000-m Rowing Performance in Trained Athletes

Hoon, M. W., Jones, A. M., Johnson, N. A., Blackwell, J. R., Broad, E. M., Lundy, B., Rice, A. J., & Burke, L. M. (2014) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2013-0207 · Cited by 119 · see citing works

Pulmonary artery pressure limits exercise capacity at high altitude

Naeije, R., Huez, S., Lamotte, M., Retailleau, K., Neupane, S., Abramowicz, D., & Faoro, V. (2010) · European Respiratory Journal · doi:10.1183/09031936.00024410 · Cited by 118 · see citing works

A reduced core to skin temperature gradient, not a critical core temperature, affects aerobic capacity in the heat

Cuddy, J. S., Hailes, W. S., & Ruby, B. C. (2014) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2014.04.002 · Cited by 96 · see citing works

Exercise and arterial adaptation in humans: uncoupling localized and systemic effects

Rowley, N., Dawson, E. A., Birk, G. K., Cable, N. T., George, K., Whyte, G. P., Thijssen, D. H. J., & GREEN, D. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01371.2010 · Cited by 93 · see citing works

Nitric Oxide and Body Temperature Control

Gerstberger, R. (1999) · Physiology · doi:10.1152/physiologyonline.1999.14.1.30 · Cited by 76 · see citing works

Effects of acute supplementation of L-arginine and nitrate on endurance and sprint performance in elite athletes

Sandbakk, S. B., Sandbakk, Ø., Peacock, O., James, P., Welde, B., Stokes, K., Böhlke, N., & Tjønna, A. E. (2015) · Nitric Oxide · doi:10.1016/j.niox.2014.10.006 · Cited by 66 · see citing works

Maximal aerobic power, lactate threshold, and running performance in master athletes

WISWELL, R. A., Jaque, S. V., MARCELL, T. J., Hawkins, S. A., Tarpenning, K. M., Constantino, N. L., & HYSLOP, D. M. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200006000-00021 · Cited by 66 · see citing works

Beetroot juice does not enhance altitude running performance in well-trained athletes

Arnold, J. T., Oliver, S. J., Lewis-Jones, T. M., Wylie, L. J., & Macdonald, J. H. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0470 · Cited by 66 · see citing works

Caffeine, but not bicarbonate, improves 6 min maximal performance in elite rowers

Christensen, P. M., Petersen, M. H., Friis, S. N., & Bangsbo, J. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0577 · Cited by 57 · see citing works

Higher endogenous nitrite levels are associated with superior exercise capacity in highly trained athletes

Totzeck, M., Hendgen-Cotta, U. B., Rammos, C., Frommke, L.-M., Knackstedt, C., Predel, H.-G., Kelm, M., & Rassaf, T. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.05.003 · Cited by 56 · see citing works

Can elite athletes benefit from dietary nitrate supplementation?

Jonvik, K. L., Nyakayiru, J., van Loon, L. J. C., & Verdijk, L. B. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00232.2015 · Cited by 55 · see citing works

Nitric oxide pathway is an important modulator of heat loss in rats during exercise

Lacerda, A. C. R., Marubayashi, U., & Coimbra, C. C. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.06.002 · Cited by 51 · see citing works

Evidence that brain nitric oxide inhibition increases metabolic cost of exercise, reducing running performance in rats

Lacerda, A. C. R., Marubayashi, U., Balthazar, C. H., & Coimbra, C. C. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.076 · Cited by 44 · see citing works

Beetroot juice reduces infarct size and improves cardiac function following ischemia–reperfusion injury: Possible involvement of endogenous H 2 S

Salloum, F. N., Sturz, G. R., Yin, C., Rehman, S., Hoke, N. N., Kukreja, R. C., & Xi, L. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214558024 · Cited by 39 · see citing works

The effect of different sources of nitrate exposure on urinary nitrate recovery in humans and its relevance to the methods of estimating nitrate exposure in epidemiological studies

Packer, P. J., Leach, S. A., Duncan, S. N., THOMPSON, M. H., & Hill, M. J. (1989) · Carcinogenesis · doi:10.1093/carcin/10.11.1989 · Cited by 35 · see citing works

Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice

Justice, J. N., Gioscia‐Ryan, R. A., Johnson, L. C., Battson, M. L., de Picciotto, N., Beck, H. J., Jiang, H., Sindler, A. L., Bryan, N. S., Enoka, R. M., et al. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00608.2014 · Cited by 31 · see citing works

Increased brain l ‐arginine availability facilitates cutaneous heat loss induced by running exercise

Wanner, S. P., Leite, L. H. R., Guimarães, J. B., & Coimbra, C. C. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12407 · Cited by 27 · see citing works

Central blockade of nitric oxide transmission impairs exercise-induced neuronal activation in the PVN and reduces physical performance

Lima, P. M. A., Santiago, H. P., Szawka, R. E., & Coimbra, C. C. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.09.002 · Cited by 18 · see citing works

Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans

Schiffer, T. A., Larsen, F. J., Lundberg, J. O., Weitzberg, E., & Lindholm, P. (2012) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2012.09.008 · Cited by 14 · see citing works

New strategies in sport nutrition to increase exercise performance

Close, G. L., Hamilton, D. L., Philp, A., Burke, L. M., & Morton, J. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.016 · Cited by 221 · see citing works

Practical Issues in Evidence-Based Use of Performance Supplements: Supplement Interactions, Repeated Use and Individual Responses

Burke, L. M. (2017) · Sports Medicine · doi:10.1007/s40279-017-0687-1 · Cited by 132 · see citing works

Swifter, higher, stronger: What’s on the menu?

Burke, L. M., & Hawley, J. A. (2018) · Science · doi:10.1126/science.aau2093 · Cited by 125 · see citing works

Nitrate supplementation improves physical performance specifically in non-athletes during prolonged open-ended tests: a systematic review and meta-analysis

Campos, H. O., Drummond, L. R., Rodrigues, Q. T., Machado, F. S. M., Pires, W., Wanner, S. P., & Coimbra, C. C. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518000132 · Cited by 62 · see citing works

Acute Dietary Nitrate Supplementation and Exercise Performance in COPD: A Double-Blind, Placebo-Controlled, Randomised Controlled Pilot Study

Curtis, K., O’Brien, K. A., Tanner, R., Polkey, J., Minnion, M., Feelisch, M., Polkey, M. I., Edwards, L. M., & Hopkinson, N. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144504 · Cited by 55 · see citing works

A critical review of citrulline malate supplementation and exercise performance

Gough, L. A., Sparks, S. A., McNaughton, L. R., Higgins, M. F., Newbury, J. W., Trexler, E. T., Faghy, M. A., & Bridge, C. A. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04774-6 · Cited by 58 · see citing works

Methodologies for Investigating Performance Changes With Supplement Use

Burke, L. M., & Peeling, P. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0325 · Cited by 50 · see citing works

Effects of Dietary Nitrates on Time Trial Performance in Athletes with Different Training Status: Systematic Review

Hlinský, T., Kumstát, M., & Vajda, P. (2020) · Nutrients · doi:10.3390/nu12092734 · Cited by 26 · see citing works

Nitrate-Containing Beetroot Juice Reduces Oxygen Consumption During Submaximal Exercise in Low but Not High Aerobically Fit Male Runners

Carriker, C. R., Vaughan, R. A., VanDusseldorp, T. A., Johnson, K. E., Beltz, N. M., McCormick, J. J., Cole, N. H., & Gibson, A. L. (2016) · Physical Activity and Nutrition · doi:10.20463/jenb.2016.0029 · Cited by 25 · see citing works

On the implication of dietary nitrate supplementation for the hemodynamic and fatigue response to cycling exercise

Thurston, T. S., Weavil, J. C., Hureau, T. J., Gifford, J. R., Georgescu, V. P., Wan, H.-Y., La Salle, D. T., Richardson, R. S., & Amann, M. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00400.2021 · Cited by 16 · see citing works

Effects of nitrate supplementation in trained and untrained muscle are modest with initial high plasma nitrite levels

Christensen, P. M., Petersen, N., Friis, S. N., Weitzberg, E., & Nybo, L. (2017) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12848 · Cited by 16 · see citing works

Neither beetroot juice supplementation nor increased carbohydrate oxidation enhance economy of prolonged exercise in elite race walkers

Burke, L. M., Hall, R., Heikura, I. A., Ross, M. L., Tee, N., Kent, G. L., Whitfield, J., Forbes, S. F., Sharma, A. P., Jones, A. M., et al. (2021) · Nutrients · doi:10.3390/nu13082767 · Cited by 15 · see citing works

The race within a race: Together on the marathon starting line but miles apart in the experience

Burke, L. M., Whitfield, J., & Hawley, J. A. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.277 · Cited by 16 · see citing works

Content of nitrate and nitrite in commercial and self‐made beetroot juices and the effect of storage temperature

Bescós, R., Rollason, M. L., Davies, T. S., & Casas‐Agustench, P. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3575 · Cited by 8 · see citing works

Last Word on Viewpoint: Can elite athletes benefit from dietary nitrate supplementation?

Jonvik, K. L., Nyakayiru, J., van Loon, L. J. C., & Verdijk, L. B. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00622.2015 · Cited by 7 · see citing works

Effects of dietary nitrate supplementation on muscular power output: Influence of supplementation strategy and population

Tan, R., Baranauskas, M. N., Karl, S. T., de Zevallos, J. O., Shei, R., Paris, H. L. R., Wiggins, C. C., & Bailey, S. J. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.05.003 · Cited by 7 · see citing works

Effects of dietary nitrate supplementation on peak power output: Influence of supplementation strategy and population

Tan, R., Baranauskas, M. N., Karl, S. T., de Zevallos, J. O., Shei, R., Paris, H. L. R., Wiggins, C. C., & Bailey, S. J. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.06.004 · Cited by 2 · see citing works

Dietary nitrate and sports performance

Jonvik (2018) · doi:10.26481/dis.20180913kj

Dietary Nitrate Supplementation and Exercise Performance in Athletes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Xie, Y., Han, Y., Du, Q., & Xu, K. (2026) · Sports · doi:10.3390/sports14100466

Last Word on Viewpoint: Can elite athletes benefit from dietary nitrate supplementation?

Jonvik, K. L., Nyakayiru, J., van Loon, L. J. C., & Verdijk, L. B. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00622.2015 · Cited by 7 · see citing works

Can elite athletes benefit from dietary nitrate supplementation?

Jonvik, K. L., Nyakayiru, J., van Loon, L. J. C., & Verdijk, L. B. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00232.2015 · Cited by 55 · see citing works

Commentary on "can elite athletes benefit from dietary nitrate supplementation?"

Porcelli, S., Bellistri, G., Pugliese, L., Rasica, L., Marzorati, M., & Pavei, G. (2015) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)

Supplementation with nitrate and nitrite salts in exercise: a word of caution

Lundberg, J. O., Larsen, F. J., & Weitzberg, E. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00521.2011 · Cited by 37 · see citing works

Dietary nitrate supplementation on endurance exercise performance in healthy adults: a systematic review and meta-analysis update

McMahon, N. F., Pavey, T., Desbrow, B., LEVERITT, M. D., & McMahon, N. F. (2018) · doi:10.13140/rg.2.2.13359.18088