Muscarinic receptors activity in the perirhinal cortex and hippocampus has differential involvement in the formation of recognition memory
Abstract
In this work we probed the effects of post-trial infusions of the muscarinic receptor antagonist scopolamine on object recognition memory formation. Scopolamine was infused bilaterally immediately after the sample phase in the perirhinal cortex or dorsal hippocampus and animals were tested for short-term (90 min) or long-term (24 h) memory. Results showed that scopolamine impaired short-term memory when injected in either the perirhinal cortex or hippocampus. Nevertheless, scopolamine disrupted long-term memory when administrated in the perirhinal cortex but not when applied in the hippocampus. Long-term memory was unaffected when scopolamine was infused 160 min after the sample phase or 90 min before test phase. Our data indicate that short-term recognition memory requires muscarinic receptors signaling in both the perirhinal cortex and hippocampus, whereas long-term recognition memory depends on muscarinic receptors in the perirhinal cortex but not hippocampus. These results support a differential involvement of muscarinic activity in these two medial temporal lobe structures in the formation of recognition memory.
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Post-sample microinjections of scopolamine into the hippocampus disrupted NOP memory after 90 min but not 24 hours.
“Post-sample microinjections of scopolamine into the hippocampus disrupted NOP memory after 90 min, but not 24 hours”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Balderas et al., 2012
Long-term NOP memory was not influenced when the injection was made 160 min after the sample trial or 90 min before the test trial.
“long-term NOP memory was also not influenced when the injection was made 160 min after the sample trial or 90 min before the test trial”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Balderas et al., 2012
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- Authors
- Balderas, I., Morin, J.-P., Rodriguez-Ortiz, C. J., & Bermudez-Rattoni, F.
- Affiliations
- Universidad Nacional Autónoma de México (MX)
- Corresponding author
- Balderas, Israela
- ORCID
- Morin, Jean-Pascal
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 97
- Issue
- 4
- Pages
- 418-424
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2037075758
- Cited by
- 29
- References
- 36
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 5 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- muscarinic receptors, scopolamine, object recognition memory, perirhinal cortex, hippocampus, short-term memory, long-term memory, medial temporal lobe, cholinergic neurotransmission, memory formation
- MeSH terms
- Animals, Hippocampus, Male, Memory, Short-Term, Receptors, Muscarinic, Scopolamine, Temporal Lobe, Rats, Wistar, Muscarinic Antagonists, Recognition, Psychology, Rats, Memory, Long-Term
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