The neurokinin-3 receptor agonist senktide facilitates the integration of memories for object, place and temporal order into episodic memory
Abstract
Senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in adult and aged rodents and to facilitate episodic-like memory (ELM) in mice when administrated before the learning trial. In the present study we assessed the effects of senktide on memory consolidation by administering it post-trial (after the learning trial) in adult rats. We applied an ELM test, based on the integrated memory for object, place and temporal order, which we developed (Kart-Teke, de Souza Silva, Huston, & Dere, 2006). This test involves two learning trials and one test trial. We examined intervals of 1h and 23 h between the learning and test trials (experiment 1) in untreated animals and found that they exhibited intact ELM after a delay of 1 h, but not 23 h. In another test for ELM performed 7 days later, vehicle or senktide (0.2 mg/kg, s.c.) was applied immediately after the second learning trial and the test was conducted 23 h later (experiment 2). Senktide treatment recovered components of ELM (memory for place and object) compared with vehicle-treated animals. After one more week, vehicle or senktide (0.2 mg/kg, s.c.) was applied post-trial and the test conducted 6h later (experiment 3). The senktide-treated group exhibited intact ELM, unlike the vehicle-treated group. Finally, animals received post-trial treatment with either vehicle or SR142801, a selective NK3-R antagonist (6 mg/kg, i.p.), 1 min before senktide injection (0.2 mg/kg, s.c.) in the ELM paradigm and were tested 6h later (experiment 4). The vehicle+senktide group showed intact ELM, while the SR142801+senktide group did not. The results indicate that senktide facilitated the consolidation or the expression of ELM and that the senktide effect was NK3-R dependent.
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Rats retain episodic-like memory for over 2 hours but not after 4-6 hours.
“Studies manipulating the time interval between trials have shown that rats retain the episodic-like memory for over 2 hours (Belblidia et al., 2015), but not after 4–6 hours (Belblidia et al., 2015; Chao et al., 2014).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2014
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- Authors
- Chao, O. Y., Nikolaus, S., Huston, J. P., & de Souza Silva, M. A.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Düsseldorf University Hospital (DE)
- Corresponding author
- Huston, Joseph P.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 114
- Pages
- 178-185
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2052651697
- Cited by
- 24
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeischaft (SO1032/2-5)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- senktide, neurokinin-3 receptor, memory consolidation, episodic-like memory, object memory, place memory, temporal order memory, memory expression, integrated memory
- MeSH terms
- Animals, Memory, Peptide Fragments, Substance P, Time Factors, Rats, Wistar, Receptors, Neurokinin-3, Rats, Memory, Episodic
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