Hippocampal neurotransmitter efflux during one-trial novel object recognition in rats
Open accessAbstract
Several lines of evidence point to a role for the hippocampal formation and contiguous temporal lobe structures in a variety of learning and memory paradigms. Presumably, these cognitive phenomena are mediated (and accompanied) by dynamic changes in neurochemical transmission that may differ between learning and recall phases. However, the neurotransmitter correlates of most memory-related tasks have not been thoroughly investigated. Here we used a one-trial object recognition paradigm paired with in vivo microdialysis to assess hippocampal acetylcholine (ACh), glutamate and GABA efflux when rats were exposed to familiar objects, and when given the option to explore familiar and novel objects. Rats preferentially explored the novel object over the familiar one when presented with the option. Regardless of object familiarity, object exploration was accompanied by an increase in hippocampal ACh efflux, while GABA efflux was unaffected. However, glutamate efflux was not increased above baseline levels by presentation of familiar objects, but was significantly enhanced in the presence of the novel object. These data suggest that the hippocampus, and in particular, hippocampal glutamate, may be involved in memory processes during novelty recognition paradigms.
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Extracellular glutamate content in the hippocampus was increased in the NOP test.
“the extracellular glutamate content in the hippocampus was increased in the NOP test”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Stanley et al., 2012
Increased hippocampal ACh efflux was found regardless of whether a familiar or novel object was presented.
“Increased hippocampal ACh efflux was also found, regardless of whether a familiar or novel object was presented”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Stanley et al., 2012
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- Authors
- Stanley, E. M., Wilson, M. A., & Fadel, J. R.
- Affiliations
- University of South Carolina (US)
- Corresponding author
- Fadel, Jim R.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 511
- Issue
- 1
- Pages
- 38-42
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC3288804
- OpenAlex
- W2009011613
- Cited by
- 57
- References
- 27
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 2
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG030646)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampus, novel object recognition, acetylcholine, glutamate, GABA, memory, object recognition memory, hippocampal formation, in vivo microdialysis
- MeSH terms
- Acetylcholine, Analysis of Variance, Animals, Behavior, Animal, Exploratory Behavior, gamma-Aminobutyric Acid, Hippocampus, Male, Memory, Rats, Inbred F344, Microdialysis, Neurotransmitter Agents, Glutamic Acid, Recognition, Psychology, Rats
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