Cited by 29Memory and Neural MechanismsHistone Deacetylase Inhibitors ResearchMemory Processes and Influences

Sodium butyrate as a selective cognitive enhancer for weak or impaired memory

Vinarskaya, Aliya Kh., Balaban, Pavel M., Roshchin, Matvey V., Zuzina, Alena B.·2021·Neurobiology of Learning and Memory

Abstract

Several recent studies showed that memory can be modulated by manipulating chromatin modifications using histone deacetylase (HDAC) inhibitors during memory formation, consolidation, and reconsolidation. We used a context fear conditioning paradigm with minimal non-painful current as a reinforcement, what elicited alertness to the context and freezing during tests in rats. Such paradigm resulted in a relatively weak memory in significant part of the rats. Here, we demonstrate that intraperitoneal administration of the HDAC inhibitor sodium butyrate immediately following memory reactivation, produced memory enhancement in rats with weak memory, however, not in rats with strong memory. Additionally, we investigated the ability of the HDAC inhibitor sodium butyrate to restore the contextual memory impaired due to the blockade of protein synthesis during memory reactivation. The results obtained evidence that the HDAC inhibitor sodium butyrate reinstated the impaired contextual memory. This enhancement effect is consistent with other studies demonstrating a role for HDAC inhibitors in the facilitation of contextual fear.

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Crossref · 10.1016/j.nlm.2021.107414

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Authors
Vinarskaya, A. K., Balaban, P. M., Roshchin, M. V., & Zuzina, A. B.
Affiliations
Russian Academy of Sciences (RU)
Corresponding author
Zuzina, Alena B.
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
2021-04
Volume
180
Pages
107414
ISSN
1074-7427 (ISSN-L)
OpenAlex
W3129917276
Cited by
29
References
56
Citations by year
2026: 4 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 2
FWCI
2.50
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministarstvo znanosti i obrazovanja (075-15-2020-801)
  • Russian Science Foundation (19-75-10067, 012)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
sodium butyrate, histone deacetylase inhibitors, cognitive enhancement, weak memory, memory impairment, contextual fear conditioning, memory reconsolidation, memory reactivation, chromatin modification, freezing behavior
MeSH terms
Animals, Conditioning, Classical, Cycloheximide, Fear, Memory, Protein Synthesis Inhibitors, Nootropic Agents, Butyric Acid, Freezing Reaction, Cataleptic, Rats, Histone Deacetylase Inhibitors

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