Sodium butyrate as a selective cognitive enhancer for weak or impaired memory
Abstract
Several recent studies showed that memory can be modulated by manipulating chromatin modifications using histone deacetylase (HDAC) inhibitors during memory formation, consolidation, and reconsolidation. We used a context fear conditioning paradigm with minimal non-painful current as a reinforcement, what elicited alertness to the context and freezing during tests in rats. Such paradigm resulted in a relatively weak memory in significant part of the rats. Here, we demonstrate that intraperitoneal administration of the HDAC inhibitor sodium butyrate immediately following memory reactivation, produced memory enhancement in rats with weak memory, however, not in rats with strong memory. Additionally, we investigated the ability of the HDAC inhibitor sodium butyrate to restore the contextual memory impaired due to the blockade of protein synthesis during memory reactivation. The results obtained evidence that the HDAC inhibitor sodium butyrate reinstated the impaired contextual memory. This enhancement effect is consistent with other studies demonstrating a role for HDAC inhibitors in the facilitation of contextual fear.
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HDAC inhibitors such as sodium butyrate and SAHA may provide therapeutic options for depressed patients with cognitive impairment.
“HDACis, such as sodium butyrate and SAHA, promote cognitive function, and may provide therapeutic options for depressed patients with cognitive impairment.405–407”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [407]
HDAC inhibitors such as sodium butyrate and SAHA promote cognitive function.
“HDACis, such as sodium butyrate and SAHA, promote cognitive function, and may provide therapeutic options for depressed patients with cognitive impairment.405–407”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [407]
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- Authors
- Vinarskaya, A. K., Balaban, P. M., Roshchin, M. V., & Zuzina, A. B.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Zuzina, Alena B.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 180
- Pages
- 107414
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W3129917276
- Cited by
- 29
- References
- 56
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 2
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministarstvo znanosti i obrazovanja (075-15-2020-801)
- Russian Science Foundation (19-75-10067, 012)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- sodium butyrate, histone deacetylase inhibitors, cognitive enhancement, weak memory, memory impairment, contextual fear conditioning, memory reconsolidation, memory reactivation, chromatin modification, freezing behavior
- MeSH terms
- Animals, Conditioning, Classical, Cycloheximide, Fear, Memory, Protein Synthesis Inhibitors, Nootropic Agents, Butyric Acid, Freezing Reaction, Cataleptic, Rats, Histone Deacetylase Inhibitors
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