The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.
Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
Open accessAbstract
Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phylogeny and amplified fragment length polymorphism typing methods report the C. auris population as clonal. Here, using whole genome sequencing analysis, we decipher for the first time that C. auris strains from four Indian hospitals were highly related, suggesting clonal transmission. Further, all C. auris isolates originated from cases of fungaemia and were resistant to fluconazole (MIC >64 mg/L).
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“particularly for species related closely enough to share the same noncanonical genetic code40,41.”
From The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles (2025) · cites this paper as [41]
Experimental — accuracy not yet measuredIn the citing paper
“Further, the identification of many putative transporter genes in the C. auris genome suggests that drug efflux may also be an important determinant of azole resistance (16–18).”
From Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance (2019) · cites this paper as [17]
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Cited by
Sorted by citations
Lockhart, S. R., Etienne, K. A., Vallabhaneni, S., Farooqi, J., Chowdhary, A., Govender, N. P., Colombo, A. L., Calvo, B., Cuomo, C. A., Desjardins, C. A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/ciw691 · Cited by 1,662
Self-citationFirst hospital outbreak of the globally emerging Candida auris in a European hospital
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Self-citationMultidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment
Arendrup, M. C., & Patterson, T. F. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix131 · Cited by 707
Candida auris: a Review of the Literature
Jeffery-Smith, A., Taori, S. K., Schelenz, S., Jeffery, K. J., Johnson, E. M., Borman, A. M., Candida auris Incident Management Team, Manuel, R. J., & Brown, C. S. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-17 · Cited by 624
Metadata
- Authors
- Sharma, C., Kumar, N., Pandey, R., Meis, J. F., & Chowdhary, A.
- Affiliations
- University of Delhi (IN)
- Wellcome Sanger Institute (GB)
- Institute of Genomics and Integrative Biology (IN)
- Radboud University Nijmegen (NL)
- Corresponding author
- Chowdhary, A.
- Venue
- New Microbes and New Infections
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 13
- Pages
- 77-82
- ISSN
- 2052-2975 (ISSN-L)
- PMC
- PMC5006800
- OpenAlex
- W2473558636
- Cited by
- 202
- References
- 24
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 18 · 2023: 18 · 2022: 15 · 2021: 22 · 2020: 23 · 2019: 31 · 2018: 21 · 2017: 21 · 2016: 6
- FWCI
- 24.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- New Microbes and New Infections (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Astellas
- Basilea
- Merck
- United Medical
- Gilead
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida auris, multidrug resistance, clonal transmission, genetic relatedness, fluconazole resistance, azole resistance, amphotericin B resistance, caspofungin resistance, emerging fungal pathogens, Indian hospitals
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