Activation of stress signalling pathways enhances tolerance of fungi to chemical fungicides and antifungal proteins

Hayes, Brigitte M. E.; Anderson, Marilyn A.; Traven, Ana; van der Weerden, Nicole L.; Bleackley, Mark R.

doi:10.1007/s00018-014-1573-8

Cited by 93Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Plant Pathogen Control

Activation of stress signalling pathways enhances tolerance of fungi to chemical fungicides and antifungal proteins

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Hayes, Brigitte M. E., Anderson, Marilyn A., Traven, Ana, van der Weerden, Nicole L., Bleackley, Mark R.·2014·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-014-1573-8PMC PMC11113482

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Abstract

Fungal disease is an increasing problem in both agriculture and human health. Treatment of human fungal disease involves the use of chemical fungicides, which generally target the integrity of the fungal plasma membrane or cell wall. Chemical fungicides used for the treatment of plant disease, have more diverse mechanisms of action including inhibition of sterol biosynthesis, microtubule assembly and the mitochondrial respiratory chain. However, these treatments have limitations, including toxicity and the emergence of resistance. This has led to increased interest in the use of antimicrobial peptides for the treatment of fungal disease in both plants and humans. Antimicrobial peptides are a diverse group of molecules with differing mechanisms of action, many of which remain poorly understood. Furthermore, it is becoming increasingly apparent that stress response pathways are involved in the tolerance of fungi to both chemical fungicides and antimicrobial peptides. These signalling pathways such as the cell wall integrity and high-osmolarity glycerol pathway are triggered by stimuli, such as cell wall instability, changes in osmolarity and production of reactive oxygen species. Here we review stress signalling induced by treatment of fungi with chemical fungicides and antifungal peptides. Study of these pathways gives insight into how these molecules exert their antifungal effect and also into the mechanisms used by fungi to tolerate sub-lethal treatment by these molecules. Inactivation of stress response pathways represents a potential method of increasing the efficacy of antifungal molecules.

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Stress response pathways are important for the integrity of the fungal cell wall and cell membrane and have been widely studied in antifungal tolerance and resistance.
“Stress response pathways are important for the integrity of fungal cell wall and cell membrane, thus have been widely studied in antifungal tolerance and resistance [66,67].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [67]

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Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris
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Authors: Hayes, B. M. E., Anderson, M. A., Traven, A., van der Weerden, N. L., & Bleackley, M. R.
Affiliations: La Trobe University (AU)
Monash University (AU)
Corresponding author: Bleackley, Mark R.
ORCID: Anderson, Marilyn A.
Traven, Ana
Bleackley, Mark R.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2014-02-14
Volume: 71
Issue: 14
Pages: 2651-2666
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-014-1573-8
PMC: PMC11113482
OpenAlex: W1965291654
Cited by: 93
References: 128
Citations by year: 2026: 7 · 2025: 13 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 12 · 2019: 5 · 2018: 9 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 5
FWCI: 0.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords: chemical fungicides, antifungal peptides, antimicrobial peptides, stress tolerance, cell wall integrity pathway, high-osmolarity glycerol pathway, reactive oxygen species, fungicide resistance, fungal diseases, sterol biosynthesis inhibition, microtubule assembly inhibition, mitochondrial respiratory chain inhibition
MeSH terms: Antifungal Agents, Cell Wall, Drug Tolerance, Fungi, Fungicides, Industrial, Osmotic Pressure, Stress, Physiological, Signal Transduction, Oxidative Stress

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Activation of stress signalling pathways enhances tolerance of fungi to chemical fungicides and antifungal proteins

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