Cited by 51Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyGrowth Hormone and Insulin-like Growth Factors

Plasma Oxytocin Concentrations in Man after Different Routes of Administration of Synthetic Oxytocin

Landgraf, R.·2009·Experimental and Clinical Endocrinology & Diabetes

Abstract

Plasma oxytocin was determined by RIA in three male subjects under basal conditions and following administration of synthetic oxytocin. As compared to basal levels (below 10 pg/ml), plasma oxytocin was found to be elevated markedly (36 to 85 pg/ml) in response to application by nasal spray (total dose: 65 to 100 micrograms). Intramuscular injection (25 micrograms) resulted in very high oxytocin levels (360 to 480 pg/ml), whereas buccal administration (70 micrograms) was proved to be ineffective (levels below 10 pg/ml plasma). In each case, plasma vasopressin remained unchanged.

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Crossref · 10.1055/s-0029-1210444

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  • By the 1980s, many laboratories had generated radioimmunoassays for oxytocin using independently produced antibodies, and most but not all required extraction.

    “By the 1980s, many laboratories had generated radioimmunoassays for oxytocin, using independently produced antibodies 58, 72, 73, 74, 94, 95, 96, 97, 98] and most, but not all 99, 100, required extraction.”

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Authors
Landgraf, R.
Affiliations
Leipzig University (DE)
Corresponding author
Landgraf, R.
Venue
Experimental and Clinical Endocrinology & Diabetes
Published
2009-07-16
Volume
85
Issue
02
Pages
245-248
ISSN
  • 0947-7349 (ISSN-L)
  • 1439-3646
OpenAlex
W2017392366
Cited by
51
References
0
Citations by year
2026: 1 · 2023: 4 · 2021: 2 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 8 · 2014: 1 · 2013: 5 · 2012: 3
FWCI
3.05
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental and Clinical Endocrinology & Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
plasma oxytocin, synthetic oxytocin, route of administration, nasal spray, intramuscular injection, buccal administration, vasopressin, male subjects
MeSH terms
Administration, Intranasal, Adult, Cheek, Humans, Injections, Intramuscular, Male, Oxytocin, Radioimmunoassay, Vasopressins

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