Plasma Oxytocin Concentrations in Man after Different Routes of Administration of Synthetic Oxytocin
Abstract
Plasma oxytocin was determined by RIA in three male subjects under basal conditions and following administration of synthetic oxytocin. As compared to basal levels (below 10 pg/ml), plasma oxytocin was found to be elevated markedly (36 to 85 pg/ml) in response to application by nasal spray (total dose: 65 to 100 micrograms). Intramuscular injection (25 micrograms) resulted in very high oxytocin levels (360 to 480 pg/ml), whereas buccal administration (70 micrograms) was proved to be ineffective (levels below 10 pg/ml plasma). In each case, plasma vasopressin remained unchanged.
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By the 1980s, many laboratories had generated radioimmunoassays for oxytocin using independently produced antibodies, and most but not all required extraction.
“By the 1980s, many laboratories had generated radioimmunoassays for oxytocin, using independently produced antibodies 58, 72, 73, 74, 94, 95, 96, 97, 98] and most, but not all 99, 100, required extraction.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [98]
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- Authors
- Landgraf, R.
- Affiliations
- Leipzig University (DE)
- Corresponding author
- Landgraf, R.
- Venue
- Experimental and Clinical Endocrinology & Diabetes
- Publisher
- Georg Thieme Verlag KG
- Published
- 2009-07-16
- Volume
- 85
- Issue
- 02
- Pages
- 245-248
- ISSN
- 0947-7349 (ISSN-L)
- 1439-3646
- OpenAlex
- W2017392366
- Cited by
- 51
- References
- 0
- Citations by year
- 2026: 1 · 2023: 4 · 2021: 2 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 8 · 2014: 1 · 2013: 5 · 2012: 3
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental and Clinical Endocrinology & Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- plasma oxytocin, synthetic oxytocin, route of administration, nasal spray, intramuscular injection, buccal administration, vasopressin, male subjects
- MeSH terms
- Administration, Intranasal, Adult, Cheek, Humans, Injections, Intramuscular, Male, Oxytocin, Radioimmunoassay, Vasopressins
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