The interaction between the oxytocin and pain modulation in headache patients
Abstract
Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory pathway. Our previous study has demonstrated that OXT in the central nervous system rather than the blood circulation plays an important role in rat pain modulation. The communication tried to investigate the interaction between the OXT and pain modulation in Chinese patients with headache to understand the OXT effect on human pain modulation. The results showed that (1) intranasal OXT could relieve the human headache in a dose-dependent manner; (2) OXT concentration in both plasma and cerebrospinal fluid (CSF) increased significantly in headache patients in relation with the pain level; and (3) there was a positive relationship between plasma and CSF OXT concentration in headache patients. The data suggested that intranasal OXT, which was delivered to the central nervous system through olfactory region, could treat human headache and OXT might be a potential drug of headache relief by intranasal administration.
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Double-blind, placebo-controlled studies have produced mixed results regarding the analgesic role of oxytocin in humans.
“However, double‐blind, placebo‐controlled studies have produced mixed results.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [19]
Some clinical reports suggested that a single intranasal oxytocin dose provided headache relief.
“In clinical groups, some reports suggested that a single intranasal oxytocin dose provided headache relief 19”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [19]
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- Authors
- Wang, Y.-L., Yuan, Y., Yang, J., Wang, C.-H., Pan, Y.-J., Lu, L., Wu, Y.-Q., Wang, D.-X., Lv, L.-X., Li, R.-R., Xue, L., Wang, X.-H., Bi, J.-W., Liu, X.-F., Qian, Y.-N., Deng, Z.-K., Zhang, Z.-J., Zhai, X.-H., Zhou, X.-J., Wang, G.-L., Zhai, J.-X., & Liu, W.-Y.
- Affiliations
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Henan Medical University (CN)
- 117th Hospital of People's Liberation Army (CN)
- Guangdong 999 Brain Hospital (CN)
- Nanfang Hospital (CN)
- Tongji University (CN)
- Army Medical University (CN)
- Chinese People's Liberation Army (CN)
- General Hospital of Guangzhou Military Command (CN)
- Wuxi Fourth People's Hospital (CN)
- Corresponding author
- Yang, Jun
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 47
- Issue
- 2
- Pages
- 93-97
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2027956310
- Cited by
- 107
- References
- 22
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 13 · 2016: 4 · 2015: 6 · 2014: 12 · 2013: 2
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- oxytocin, headache, pain modulation, intranasal administration, olfactory pathway, cerebrospinal fluid, blood-brain barrier, headache treatment
- MeSH terms
- Administration, Intranasal, Adult, Dose-Response Relationship, Drug, Female, Headache, Humans, Male, Middle Aged, Oxytocin, Pain, Pain Measurement, Asian People, Young Adult
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