Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects
Abstract
Background & aims A growing body of evidence suggests that beta-glucan derived from oats or barley can reduce cardiovascular disease risk through reductions in serum lipids. However, the effects of beta-glucan on lipid changes in hypercholesterolemic patient groups are inconsistent. The objective of this study was to identify and quantify the effect of beta-glucan, a marker of water-soluble fiber, on various lipid parameters and glucose level in hypercholesterolemic subjects.Methods and results We performed a comprehensive literature search to identify the relevant randomized controlled trials (RCTs) that investigated the effects of beta-glucan consumption in hypercholesterolemic subjects. Mean differences (MDs) and 95% confidence intervals (CIs) were calculated for net changes in lipid concentrations by using fixed-effects or random-effects models according to heterogeneity. Publication bias, sensitivity analysis and subgroup analyses were also performed. Seventeen eligible RCTs with 916 subjects were included in the meta-analysis. The pooled result showed that beta-glucan consumption in hypercholesterolemic population significantly lowered the total cholesterol (TC) (MD, -0.26 mmol/L; 95% CI, -0.33 to -0.18; P < 0.00001) and low-density lipoprotein (LDL)-cholesterol concentration (MD, -0.21 mmol/L; 95% CI, -0.27 to -0.14; P < 0.00001). However, there were no significant differences in high-density lipoprotein (HDL)-cholesterol, triglycerides (TG) and glucose. No adverse effects were reported among the eligible trials.Conclusion Our meta-analysis showed that beta-glucan consumption significantly decreased TC and LDL-cholesterol concentrations but did not affect TG, HDL-cholesterol, and glucose concentrations in hypercholesterolemic subjects.
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β-Glucan consumption in hypercholesterolemic patients significantly reduces LDL-C by 0.21 mmol/L.
“β-glucan consumption in hypercholesterolemic patients significantly reduced LDL-C (− 0.21 mmol/L [8.1 mg/dL] (95% CI: 0.27; − 0.14), p < 0.00001)”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [19]
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- Authors
- Zhu, X., Sun, X., Wang, M., Zhang, C., Cao, Y., Mo, G., Liang, J., & Zhu, S.
- Affiliations
- Gaozhou People's Hospital (CN)
- Corresponding author
- Zhu, X.
- Venue
- Nutrition, Metabolism and Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 25
- Issue
- 8
- Pages
- 714-723
- ISSN
- 0939-4753 (ISSN-L)
- OpenAlex
- W2139380238
- Cited by
- 78
- References
- 37
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 16 · 2019: 5 · 2018: 11 · 2017: 8 · 2016: 1 · 2015: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- β-glucan, hypercholesterolemia, lipid profile, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, blood glucose, oat, barley, dietary fiber, cardiovascular risk
- MeSH terms
- Hordeum, Blood Glucose, Cholesterol, Dietary Fiber, Female, Humans, Hypercholesterolemia, Lipoproteins, HDL, Cholesterol, LDL, Male, Triglycerides, Treatment Outcome, Avena, beta-Glucans
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