A Randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study
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The Beta-glucan Effects on Lipid profile, glycemia and inTestinal health (BELT) Study investigated the effect of 3 g/day oat beta-glucans on plasma lipids, fasting glucose and self-perceived intestinal well-being. The Study was an 8-week, double-blind, placebo-controlled, cross-over randomized clinical trial, enrolling a sample of 83 Italian free-living subjects, adherent to Mediterranean diet, with a moderate hypercholesterolemia and a low cardiovascular risk profile. Beta-glucans reduced mean LDL-Cholesterol (LDL-C) levels from baseline by 12.2% (95%CI: −15.4 to −3.8) after 4 weeks of supplementation and by 15.1% (95%CI: −17.8 to −5.9) after 8 weeks of supplementation (p < 0.01 for both comparison and versus placebo). Between baseline and 4 weeks Total Cholesterol (TC) levels showed an average reduction of 6.5% (95%CI: −10.9 to −1.9) in the beta-glucan sequence; while non-HDL-C plasma concentrations decreased by 11.8% (95%CI: −14.6 to −4.5). Moreover, after 8 weeks of beta-glucan supplementation TC was reduced by 8.9% (95%CI: −12.6 to −2.3) and non-HDL-C levels by 12.1% (95%CI: −15.6 to −5.3). Decreses in TC and non HDL-C were significant also versus placebo (respectively p < 0.05 and p < 0.01 to both follow-up visits). Fasting plasma glucose and self-perceived intestinal well-being were not affected by both beta-glucan and placebo supplementation.
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Addition of oat fibers to a Mediterranean diet induces an LDL-C reduction of 15.1%.
“In a recent trial, the addition of oat fibers to a Mediterranean diet induced an LDL-C reduction of 15.1% (95% CI: − 17.8 to − 5.9) [20].”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [20]
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- Authors
- Cicero, A. F. G., Fogacci, F., Veronesi, M., Strocchi, E., Grandi, E., Rizzoli, E., Poli, A., Marangoni, F., & Borghi, C.
- Affiliations
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Nutrition Foundation of Italy, Viale Tunisia 38, 20124 Milan, Italy
- Corresponding author
- Cicero, Arrigo F.G.
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-03-03
- Volume
- 12
- Issue
- 3
- Pages
- 686
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7146517
- OpenAlex
- W3009235808
- Cited by
- 106
- References
- 29
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 21 · 2023: 25 · 2022: 20 · 2021: 12 · 2020: 3
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- undefined <span style="color:gray;font-size:10px;">undefined</span> (BELT 2018)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- oat β-glucan, oat fiber, LDL cholesterol, non-HDL cholesterol, total cholesterol, plasma lipids, fasting blood glucose, glycemia, hypercholesterolemia, Mediterranean diet, dietary supplementation, medium-term effects
- MeSH terms
- Adult, Aged, Blood Glucose, Dietary Fiber, Double-Blind Method, Fasting, Female, Humans, Hypercholesterolemia, Lipids, Male, Middle Aged, Avena, Cross-Over Studies, beta-Glucans
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