Cited by 106Food composition and propertiesMicrobial Metabolites in Food BiotechnologyLipoproteins and Cardiovascular Health

A Randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study

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Cicero, Arrigo F.G., Fogacci, Federica, Veronesi, Maddalena, Strocchi, Enrico, Grandi, Elisa, Rizzoli, Elisabetta, Poli, Andrea, Marangoni, Franca +1 more·2020·Nutrients

Abstract

The Beta-glucan Effects on Lipid profile, glycemia and inTestinal health (BELT) Study investigated the effect of 3 g/day oat beta-glucans on plasma lipids, fasting glucose and self-perceived intestinal well-being. The Study was an 8-week, double-blind, placebo-controlled, cross-over randomized clinical trial, enrolling a sample of 83 Italian free-living subjects, adherent to Mediterranean diet, with a moderate hypercholesterolemia and a low cardiovascular risk profile. Beta-glucans reduced mean LDL-Cholesterol (LDL-C) levels from baseline by 12.2% (95%CI: −15.4 to −3.8) after 4 weeks of supplementation and by 15.1% (95%CI: −17.8 to −5.9) after 8 weeks of supplementation (p < 0.01 for both comparison and versus placebo). Between baseline and 4 weeks Total Cholesterol (TC) levels showed an average reduction of 6.5% (95%CI: −10.9 to −1.9) in the beta-glucan sequence; while non-HDL-C plasma concentrations decreased by 11.8% (95%CI: −14.6 to −4.5). Moreover, after 8 weeks of beta-glucan supplementation TC was reduced by 8.9% (95%CI: −12.6 to −2.3) and non-HDL-C levels by 12.1% (95%CI: −15.6 to −5.3). Decreses in TC and non HDL-C were significant also versus placebo (respectively p < 0.05 and p < 0.01 to both follow-up visits). Fasting plasma glucose and self-perceived intestinal well-being were not affected by both beta-glucan and placebo supplementation.

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Authors
Cicero, A. F. G., Fogacci, F., Veronesi, M., Strocchi, E., Grandi, E., Rizzoli, E., Poli, A., Marangoni, F., & Borghi, C.
Affiliations
  • IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
  • Nutrition Foundation of Italy, Viale Tunisia 38, 20124 Milan, Italy
Corresponding author
Cicero, Arrigo F.G.
Venue
Nutrients
Publisher
MDPI AG
Published
2020-03-03
Volume
12
Issue
3
Pages
686
ISSN
2072-6643 (ISSN-L)
OpenAlex
W3009235808
Cited by
106
References
29
Citations by year
2026: 12 · 2025: 13 · 2024: 21 · 2023: 25 · 2022: 20 · 2021: 12 · 2020: 3
FWCI
9.48
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
undefined &lt;span style=&quot;color:gray;font-size:10px;&quot;&gt;undefined&lt;/span&gt; (BELT 2018)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
oat β-glucan, oat fiber, LDL cholesterol, non-HDL cholesterol, total cholesterol, plasma lipids, fasting blood glucose, glycemia, hypercholesterolemia, Mediterranean diet, dietary supplementation, medium-term effects
MeSH terms
Adult, Aged, Blood Glucose, Dietary Fiber, Double-Blind Method, Fasting, Female, Humans, Hypercholesterolemia, Lipids, Male, Middle Aged, Avena, Cross-Over Studies, beta-Glucans

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