The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects
Abstract
Background and aims This study evaluated the triglyceride (TG)-lowering effects of consuming dual probiotic strains of Lactobacillus curvatus (L. curvatus) HY7601 and Lactobacillus plantarum (L. plantarum) KY1032 on the fasting plasma metabolome.Methods and results A randomized, double-blind, placebo-controlled study was conducted on 92 participants with hypertriglyceridemia but without diabetes. Over a 12-week testing period, the probiotic group consumed 2 g of powder containing 5 × 10(9) colony-forming units (cfu) of L. curvatus HY7601 and 5 × 10(9) cfu of L. plantarum KY1032 each day, whereas the placebo group consumed the same product without probiotics. Fasting plasma metabolomes were profiled using UPLC-LTQ-Orbitrap MS. After 12 weeks of treatment, the probiotic group displayed a 20% reduction (p = 0.001) in serum TGs and 25% increases (p=0.001) in apolipoprotein A-V (apoA-V). At the 12-week follow-up assessment, the following 11 plasma metabolites were significantly reduced in the probiotic group than the placebo group: palmitoleamide, palmitic amide, oleamide, and lysophosphatidyl choline (lysoPC) containing C14:0, C16:1, C16:0, C17:0, C18:3, C18:2, C18:1, and C20:3. In the probiotic group, changes (▵) in TG were negatively correlated with ▵ apoA-V, which was positively correlated with ▵ FFA. In addition, ▵ FFA was strongly and positively correlated with ▵ lysoPCs in the probiotic group but not the placebo group.Conclusions The triglyceride-lowering effects of probiotic supplementation, partly through elevated apoA-V, in borderline to moderate hypertriglyceridemic subjects showed reductions in plasma metabolites, fatty acid primary amides and lysoPCs (NCT02215694; http://www.clinicaltrials.gov). Clinical trials: NCT02215694; http://www.clinicaltrials.gov.
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A dosage of 5 × 10^9 CFU/mL has been widely utilized in the field of probiotic preparations.
“Therefore, the dosage of 5 × 109 CFU/mL has been widely utilized in the field of probiotic preparations.”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Ahn et al., 2015
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- Authors
- Ahn, H. Y., Kim, M., Ahn, Y.-T., Sim, J.-H., Choi, I.-D., Lee, S.-H., & Lee, J. H.
- Affiliations
- Yonsei University (KR)
- Korea Yakult (South Korea) (KR)
- National Health Insurance Service Ilsan Hospital (KR)
- Corresponding author
- Lee, J.H.
- ORCID
- Kim, M.
- Venue
- Nutrition Metabolism and Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 25
- Issue
- 8
- Pages
- 724-733
- ISSN
- 0939-4753 (ISSN-L)
- OpenAlex
- W1682434661
- Cited by
- 44
- References
- 40
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 8 · 2021: 2 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 2
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bio-Synergy Research Project (NRF-2012M3A9C4048762)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- hypertriglyceridemia, triglyceride lowering, lysophosphatidylcholine, apolipoprotein A-V, fatty acid amides, oleamide, free fatty acids
- MeSH terms
- Apolipoprotein A-V, Adult, Aged, Apolipoproteins A, Double-Blind Method, Fasting, Fatty Acids, Female, Follow-Up Studies, Humans, Lysophosphatidylcholines, Male, Middle Aged, Triglycerides, Hypertriglyceridemia, Treatment Outcome, Dietary Supplements, Probiotics, Lactiplantibacillus plantarum
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