Cited by 230Probiotics and Fermented FoodsGut microbiota and healthDiet, Metabolism, and Disease

Probiotics L. plantarum and L. curvatus in Combination Alter Hepatic Lipid Metabolism and Suppress Diet‐Induced Obesity

Yoo, Sae‐Rom, Kim, Young‐Jae, Park, Do‐Young, Jung, Un‐Ju, Jeon, Seon‐Min, Ahn, Young‐Tae, Huh, Chul‐Sung, McGregor, Robin +1 more·2013·Obesity

Abstract

Objective: To determine the effects of naturally derived probiotic strains individually or combination on a short‐term diet‐induced obesity model. Design and Methods: C57BL/6J mice ( n = 50) were randomly divided into five groups, then fed a high‐fat high‐cholesterol diet (HFCD), HFCD and Lactobacillus plantarum KY1032 (PL, 10 10 cfu/day), HFCD and Lactobacillus curvatus HY7601 (CU, 10 10 cfu/day), HFCD and in combination with PL+CU (10 10 cfu/day), or a normal diet (ND) for 9 weeks. Results: PL and CU showed distinct and shared metabolic activity against a panel of 50 carbohydrates. Fat accumulation in adipose tissue and liver was significantly reduced by probiotic strains CU or PL+CU. Probiotic strains CU or PL+CU reduced cholesterol in plasma and liver, while PL+CL had a synergistic effect on hepatic triglycerides. Probiotic strains PL+CU combination was more effective for inhibiting gene expressions of various fatty acid synthesis enzymes in the liver, concomitant with decreases in fatty acid oxidation‐related enzyme activities and their gene expressions. Conclusions: Multi‐strain probiotics may prove more beneficial than single‐strain probiotics to combat fat accumulation and metabolic alterations in diet‐induced obesity.

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Crossref · 10.1002/oby.20428

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  • In mice fed a high-fat high-cholesterol diet, Lactobacillus curvatus alone or together with Lactobacillus plantarum reduced cholesterol in plasma and liver and the two strains had a synergistic effect on hepatic triglycerides.

    “In mice fed a high-fat high-cholesterol diet, Lactobacillus curvatus alone or together with Lactobacillus plantarum reduced cholesterol in plasma and liver and the two strains had a synergistic effect on hepatic triglycerides [34].”

    From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [34]

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Authors
Yoo, S., Kim, Y., Park, D., Jung, U., Jeon, S., Ahn, Y., Huh, C., McGregor, R., & Choi, M. S.
Affiliations
  • National Research Foundation of Korea (KR)
  • Kyungpook National University (KR)
  • Department of Biological Science Seoul National University Daehak‐dong, Gwanak‐gu, Seoul 151‐742 Seoul Republic of Korea
  • Korea Yakult (South Korea) (KR)
  • University of Auckland (NZ)
Corresponding author
Choi, Myung Sook
Venue
Obesity
Publisher
Wiley
Published
2013-06-11
Volume
21
Issue
12
Pages
2571-2578
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
OpenAlex
W1583400374
Cited by
230
References
39
Citations by year
2026: 10 · 2025: 15 · 2024: 24 · 2023: 26 · 2022: 23 · 2021: 19 · 2020: 24 · 2019: 15 · 2018: 24 · 2017: 13 · 2016: 19 · 2015: 8 · 2014: 8 · 2013: 2
FWCI
18.37
Type
journal article
Language
en
Open access
closed
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
Lactobacillus plantarum, Lactobacillus curvatus, multi-strain probiotics, diet-induced obesity, hepatic lipid metabolism, high-fat high-cholesterol diet, hepatic triglycerides, fatty acid synthesis, fatty acid oxidation, hepatic lipid accumulation
MeSH terms
Adipose Tissue, Animals, Anti-Inflammatory Agents, Cholesterol, Cholesterol, Dietary, Lactobacillus, Liver, Male, Mice, Inbred C57BL, Obesity, Triglycerides, Tumor Necrosis Factor-alpha, Interleukin-6, Gene Expression, Probiotics, Lipogenesis, Mice, Interleukin-1beta, Diet, High-Fat

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