Probiotics L. plantarum and L. curvatus in Combination Alter Hepatic Lipid Metabolism and Suppress Diet‐Induced Obesity
Abstract
Objective: To determine the effects of naturally derived probiotic strains individually or combination on a short‐term diet‐induced obesity model. Design and Methods: C57BL/6J mice ( n = 50) were randomly divided into five groups, then fed a high‐fat high‐cholesterol diet (HFCD), HFCD and Lactobacillus plantarum KY1032 (PL, 10 10 cfu/day), HFCD and Lactobacillus curvatus HY7601 (CU, 10 10 cfu/day), HFCD and in combination with PL+CU (10 10 cfu/day), or a normal diet (ND) for 9 weeks. Results: PL and CU showed distinct and shared metabolic activity against a panel of 50 carbohydrates. Fat accumulation in adipose tissue and liver was significantly reduced by probiotic strains CU or PL+CU. Probiotic strains CU or PL+CU reduced cholesterol in plasma and liver, while PL+CL had a synergistic effect on hepatic triglycerides. Probiotic strains PL+CU combination was more effective for inhibiting gene expressions of various fatty acid synthesis enzymes in the liver, concomitant with decreases in fatty acid oxidation‐related enzyme activities and their gene expressions. Conclusions: Multi‐strain probiotics may prove more beneficial than single‐strain probiotics to combat fat accumulation and metabolic alterations in diet‐induced obesity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In mice fed a high-fat high-cholesterol diet, Lactobacillus curvatus alone or together with Lactobacillus plantarum reduced cholesterol in plasma and liver and the two strains had a synergistic effect on hepatic triglycerides.
“In mice fed a high-fat high-cholesterol diet, Lactobacillus curvatus alone or together with Lactobacillus plantarum reduced cholesterol in plasma and liver and the two strains had a synergistic effect on hepatic triglycerides [34].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [34]
Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952 · see citing works
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · see citing works
Everard, A., Lazarevic, V., Derrien, M., Girard, M., Muccioli, G. G., Neyrinck, A. M., Possemiers, S., Van Holle, A., François, P., de Vos, W. M., et al. (2011) · Diabetes · doi:10.2337/db11-0227 · Cited by 1,076 · see citing works
Genes and Molecules of Lactobacilli Supporting Probiotic Action
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-08 · Cited by 1,013 · see citing works
Targeting gut microbiota in obesity: effects of prebiotics and probiotics
Delzenne, N. M., Neyrinck, A. M., Bäckhed, F., & Cani, P. D. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.126 · Cited by 783 · see citing works
Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
Sérino, M., Luche, É., Grès, S., Baylac, A., Bergé, M., Cénac, C., Waget, A., Klopp, P., Iacovoni, J. S., Klopp, C., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-301012 · Cited by 621 · see citing works
Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes
Musso, G., Gambino, R., & Cassader, M. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012510-175505 · Cited by 598 · see citing works
Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice
Membrez, M., Blancher, F., Jaquet, M., Bibiloni, R., Cani, P. D., Burcelin, R. G., Corthesy, I., Macé, K., & Chou, C. J. (2008) · The FASEB Journal · doi:10.1096/fj.07-102723 · Cited by 493 · see citing works
Fatty Acid Regulation of Hepatic Gene Transcription
Jump, D. Β., Botolin, D., Wang, Y., Xu, J., Christian, B., & Demeure, O. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2503 · Cited by 477 · see citing works
Effects of Consumption of Probiotics and Prebiotics on Serum Lipid Levels in Humans
Pereira, D. I. A., & Gibson, G. R. (2002) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230290771519 · Cited by 450 · see citing works
Ma, X., Hua, J., & Li, Z. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.05.025 · Cited by 413 · see citing works
[19] Assay of peroxisomal β-oxidation of fatty acids
Lazarow, P. B. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)72021-4 · Cited by 367 · see citing works
The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
Kootte, R. S., Vrieze, A., Holleman, F., Dallinga‐Thie, G. M., Zoetendal, E. G., de Vos, W. M., Groen, A. K., Hoekstra, J. B. L., Stroes, E. S. G., & Nieuwdorp, M. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01483.x · Cited by 348 · see citing works
Aronsson, L., Huang, Y., Parini, P., Korach-André, M., Håkansson, J., Gustafsson, J.-Å., Pettersson, S., Arulampalam, V., & Rafter, J. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013087 · Cited by 298 · see citing works
Preiss, D., & Sattar, N. A. (2008) · Clinical Science · doi:10.1042/cs20070402 · Cited by 292 · see citing works
[6] Fatty acid synthase from rat liver
Nepokroeff, C. M., Lakshmanan, M. R., & Porter, J. W. (1975) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(75)35136-7 · Cited by 270 · see citing works
Effects of fourBifidobacteriaon obesity in high-fat diet induced rats
Yin, Y. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i27.3394 · Cited by 259 · see citing works
Programming of Host Metabolism by the Gut Microbiota
Bäckhed, F. (2011) · Annals of Nutrition and Metabolism · doi:10.1159/000328042 · Cited by 256 · see citing works
Probiotics Reduce the Inflammatory Response Induced by a High-Fat Diet in the Liver of Young Rats
Esposito, E., Iacono, A., Bianco, G., Autore, G., Cuzzocrea, S., Vajro, P., Canani, R. B., Calignano, A., Raso, G. M., & Meli, R. (2009) · Journal of Nutrition · doi:10.3945/jn.108.101808 · Cited by 238 · see citing works
Xie, N., Cui, Y., Yin, Y.-N., Zhao, X., Yang, J.-W., Wang, Z.-G., Fu, N., Tang, Y., Wang, X.-H., Liu, X.-W., et al. (2011) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-11-53 · Cited by 211 · see citing works
Wolfram, S., Raederstorff, D., Wang, Y., Teixeira, S. R., Elste, V., & Weber, P. (2005) · Annals of Nutrition and Metabolism · doi:10.1159/000084178 · Cited by 202 · see citing works
Probiotic characteristics of lactic acid bacteria isolated from kimchi
Chang, J. ‐., Shim, Y. Y., Cha, S.-K., & Chee, K. M. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2009.04648.x · Cited by 123 · see citing works
Czubayko, F., Beumers, B., Lammsfuss, S., Lütjohann, D., & von Bergmann, K. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41640-2 · Cited by 123 · see citing works
Probiotics lower plasma glucose in the high-fat fed C57BL/6J mouse
Andersson, U., Bränning, C., Ahrné, S., Molin, G., Alenfall, J., Önning, G., NYMAN, M. E., & Holm, C. (2010) · Beneficial Microbes · doi:10.3920/bm2009.0036 · Cited by 115 · see citing works
Uronis, J. M., Arthur, J. C., Keku, T. O., Fodor, A. A., Carroll, I. M., Cruz, M. L., Appleyard, C. B., & Jobin, C. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21366 · Cited by 105 · see citing works
Do, G., Oh, H. Y., Kwon, E., Cho, Y., Shin, S., Park, H., Jeon, S.-M., Kim, E., Hur, C., Park, T., et al. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100064 · Cited by 77 · see citing works
Self-citationGérard, P., Béguet, F., Lepercq, P., Rigottier‐Gois, L., Rochet, V., Andrieux, C., & Juste, C. (2004) · FEMS Microbiology Ecology · doi:10.1016/s0168-6496(03)00285-x · Cited by 76 · see citing works
Veiga, P., Juste, C., Lepercq, P., Saunier, K., Béguet, F., & Gérard, P. (2004) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2004.10.042 · Cited by 74 · see citing works
Post, S. M., Zoeteweij, P. J., Bos, M. H. A., de Wit, E. C., Havinga, R., Kuipers, F., & Princen, H. M. G. (1999) · Hepatology · doi:10.1002/hep.510300230 · Cited by 50 · see citing works
Paik, H., Park, J. J., & Park, E. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1270 · Cited by 49 · see citing works
[42] Peroxisomal and microsomal carnitine acetyltransferases
BIEBER, L. L., & Markwell, M. A. K. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(81)71044-9 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529 · see citing works
Dietary lipids, gut microbiota and lipid metabolism
Schoeler, M., & Caesar, R. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09512-0 · Cited by 1,163 · see citing works
Wang, J., Tang, H., Zhang, C., Zhao, Y., Derrien, M., Rocher, E., Vlieg, J. E. V. H., Strissel, K. J., Zhao, L., Obin, M. S., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.99 · Cited by 833 · see citing works
Aron-Wisnewsky, J., Warmbrunn, M. V., Nieuwdorp, M., & Clément, K. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.057 · Cited by 452 · see citing works
The gut microbiome and its role in obesity
Davis, C. D. (2016) · Nutrition Today · doi:10.1097/nt.0000000000000167 · Cited by 407 · see citing works
You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review
Moszak, M., Szulińska, M., & Bogdański, P. (2020) · Nutrients · doi:10.3390/nu12041096 · Cited by 397 · see citing works
Shang, Q., Shan, X., Cai, C., Hao, J., Li, G., & Yu, G. (2016) · Food & Function · doi:10.1039/c6fo00309e · Cited by 359 · see citing works
Probiotics in prevention and treatment of obesity: a critical view
Kobyliak, N. M., Conte, C., Cammarota, G., Haley, A. P., Štyriak, I., Gašpar, Ľ., Fusek, J., Rodrigo, L., & Kružliak, P. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0067-0 · Cited by 359 · see citing works
Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics
He, M., & Shi, B. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0183-1 · Cited by 343 · see citing works
Interplay between food and gut microbiota in health and disease
Danneskiold‐Samsøe, N. B., Barros, H. D. D. F. Q., dos Santos, R., Bicas, J. L., Cazarin, C. B. B., Madsen, L., Kristiansen, K., Pastore, G. M., Brix, S., & Maróstica, M. R. (2018) · Food Research International · doi:10.1016/j.foodres.2018.07.043 · Cited by 271 · see citing works
The role of intestinal microbiota in cardiovascular disease
Jin, M., Qian, Z., Yin, J., Xu, W., & Zhou, X. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14195 · Cited by 236 · see citing works
Yan, F., Li, N., Shi, J., Li, H., Yue, Y., Jiao, W., Wang, N., Song, Y., Huo, G., & Li, B. (2019) · Food & Function · doi:10.1039/c9fo01062a · Cited by 225 · see citing works
Probiotics: How Effective Are They in the Fight against Obesity?
Mazloom, K., Siddiqi, I., & Covașă, M. (2019) · Nutrients · doi:10.3390/nu11020258 · Cited by 198 · see citing works
Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics
Evivie, S. E., Huo, G., Igene, J. O., & Bian, X. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2017.1318034 · Cited by 189 · see citing works
Balakumar, M., Prabhu, D., Chandrakumar, S., Paramasivam, P., Rokana, N., Kumar, R. K., Raghavan, S., Soundararajan, A., Grover, S., Batish, V. K., et al. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1317-7 · Cited by 187 · see citing works
Hsieh, M., Tsai, W.-H., Jheng, Y.-P., Su, S., Wang, S., Lin, C., Chen, Y.-H., & Chang, W. (2018) · Scientific Reports · doi:10.1038/s41598-018-35014-1 · Cited by 182 · see citing works
Adipose tissue inflammation and metabolic syndrome. The proactive role of probiotics
Torres, S., Fabersani, E., Marquez, A., & Gauffin-Cano, P. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1790-2 · Cited by 171 · see citing works
Novel opportunities for next-generation probiotics targeting metabolic syndrome
Cani, P. D., & Van Hul, M. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.10.006 · Cited by 167 · see citing works
Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota
Mishra, A. K., Dubey, V., & Ghosh, A. R. (2016) · Metabolism · doi:10.1016/j.metabol.2015.10.008 · Cited by 161 · see citing works
Immobilization Technologies in Probiotic Food Production
Mitropoulou, G., Nedović, V., Goyal, A., & Kourkoutas, Y. (2013) · Journal of Nutrition and Metabolism · doi:10.1155/2013/716861 · Cited by 161 · see citing works
Ke, X., Walker, A., Haange, S., Lagkouvardos, I., Liu, Y., Schmitt‐Kopplin, P., von Bergen�, M., Jehmlich, N., He, X., Clavel, T., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.01.012 · Cited by 160 · see citing works
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders
Maioli, T. U., Nogués, E. B., Torres, L., Barbosa, S. C., Martins, V. D., Langella, P., Azevedo, V., & Chatel, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.740636 · Cited by 151 · see citing works
Probiotics as Complementary Treatment for Metabolic Disorders
Le Barz, M., Anhê, F. F., Varin, T. V., Desjardins, Y., Levy, E., Roy, D., Urdaci, M. C., & Marette, A. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.4.291 · Cited by 142 · see citing works
Dietary strategies to reduce metabolic syndrome
Andersen, C. J., & Fernández, M. L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9251-y · Cited by 142 · see citing works
Vallianou, N. G., Kounatidis, D. C., Tsilingiris, D., Panagopoulos, F., Christodoulatos, G. S., Evangelopoulos, A. A., Karampela, Ι., & Dalamaga, Μ. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076755 · Cited by 139 · see citing works
Bo, T., Wen, J., Zhao, Y.-C., Tian, S.-J., Zhang, X., & Wang, D. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105602 · Cited by 132 · see citing works
Genetic and microbiome influence on lipid metabolism and dyslipidemia
Matey-Hernandez, M. L., Williams, F. M. K., Potter, T. I. T., Valdes, A. M., Spector, T. D., & Menni, C. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00053.2017 · Cited by 129 · see citing works
Probiotics for the treatment of depressive symptoms: An anti-inflammatory mechanism?
Park, C., Brietzke, E. M., Rosenblat, J. D., Musial, N., Zuckerman, H., Ragguett, R., Pan, Z., Rong, C., Fus, D., & McIntyre, R. S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.006 · Cited by 128 · see citing works
The role of the gut microbiota in health and cardiovascular diseases
Wang, L., Wang, S., Zhang, Q., He, C., Fu, C., & Wei, Q. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00091-2 · Cited by 124 · see citing works
Hsieh, F.-C., Lan, C.-C. E., Huang, T.-Y., Chen, K., Chai, C., Chen, W., Fang, A.-H., Chen, Y., & Wu, C. (2016) · Food & Function · doi:10.1039/c5fo01396h · Cited by 116 · see citing works
Links between Dietary Protein Sources, the Gut Microbiota, and Obesity
Madsen, L., Myrmel, L. S., Fjære, E., Liaset, B., & Kristiansen, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01047 · Cited by 110 · see citing works
Al-Muzafar, H. M., & Amin, K. A. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1540-z · Cited by 111 · see citing works
Nobili, V., Putignani, L., Mosca, A., CHIERICO, F. D., Vernocchi, P., Alisi, A., Stronati, L., Cucchiara, S., Toscano, M., & Drago, L. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.62150 · Cited by 106 · see citing works
Modulation of the Gut Microbiota by Nutrients with Prebiotic and Probiotic Properties
Druart, C., Alligier, M., Salazar, N., Neyrinck, A. M., & Delzenne, N. M. (2014) · Advances in Nutrition · doi:10.3945/an.114.005835 · Cited by 103 · see citing works
Is It Time to Use Probiotics to Prevent or Treat Obesity?
Brusaferro, A., Cozzali, R., Orabona, C., Biscarini, A., Farinelli, E., Cavalli, E., Grohmann, U., Principi, N., & Esposito, S. (2018) · Nutrients · doi:10.3390/nu10111613 · Cited by 102 · see citing works
Oral delivery of bacteria: Basic principles and biomedical applications
Li, S., Jiang, W., Zheng, C., Shao, D., Liu, Y., Huang, S., Han, J., Ding, J., Tao, Y., & Li, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.011 · Cited by 95 · see citing works
Obesity and Asthma: Microbiome–Metabolome Interactions
Shore, S. A., & Cho, Y. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0052ps · Cited by 86 · see citing works
Zhang, F., Qiu, L., Xu, X., Liu, Z., Zhan, H., Tao, X., Shah, N. P., & Wei, H. (2016) · Journal of Dairy Science · doi:10.3168/jds.2016-11870 · Cited by 85 · see citing works
Wang, Y., Heng, C., Zhou, X., Cao, G., Jiang, L., Wang, J., Li, K., Wang, D., & Zhan, X. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520002755 · Cited by 85 · see citing works
Microbiota manipulation for weight change
Dror, T., Dickstein, Y., Dubourg, G., & Paul, M. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.01.002 · Cited by 84 · see citing works
Hepatic Lipid Metabolism Disorder and Atherosclerosis
Zhang, S., Hong, F., Ma, C., & Yang, S. (2021) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666211220110810 · Cited by 83 · see citing works
Plaza‐Díaz, J., Gómez‐Llorente, C., Abadía‐Molina, F., Sáez‐Lara, M. J., Campaña‐Martín, L., Muñoz‐Quezada, S., Romero, F., Gil, Á., & Fontana, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098401 · Cited by 81 · see citing works
Tomato seed oil attenuates hyperlipidemia and modulates gut microbiota in C57BL/6J mice
He, W., Li, L., Rui, J., Li, J., Sun, Y., Cui, D., & Xu, B. (2020) · Food & Function · doi:10.1039/d0fo00133c · Cited by 81 · see citing works
Effect of Lactobacillus acidophilus NS1 on plasma cholesterol levels in diet-induced obese mice
Song, M., Park, S. M., Lee, H., Min, B. S., Jung, S. H., Park, S., Kim, E., & Oh, S. (2014) · Journal of Dairy Science · doi:10.3168/jds.2014-8586 · Cited by 78 · see citing works
The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice
Michael, D. R., Davies, T. S., Moss, J. W. E., de la Lama-Calvente, D., Ramji, D. P., Marchesi, J. R., Pechlivanis, A., Plummer, S. F., & Hughes, T. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-02889-5 · Cited by 79 · see citing works
Beneficial microbiota. Probiotics and pharmaceutical products in functional nutrition and medicine
Novik, G. I., & Savich, V. V. (2019) · Microbes and Infection · doi:10.1016/j.micinf.2019.06.004 · Cited by 77 · see citing works
Jung, S., Lee, Y. J., Kim, M., Kim, M., Kwak, J. H., Lee, J., Ahn, Y.-T., Jae-Hun, S., & Lee, J. H. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.10.006 · Cited by 77 · see citing works
Self-citationChen, Y., Lin, Y., Lin, J., Yang, N., & Chen, M. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700903 · Cited by 77 · see citing works
Wang, W., Wang, J., Zhang, H., Wu, S., & Qi, G. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00600 · Cited by 74 · see citing works
Probiotics and nutraceuticals as a new frontier in obesity prevention and management
Kobyliak, N. M., Falalyeyeva, T. M., Boyko, N., Tsyryuk, O., Beregova, T. V., & Остапченко, Л. І. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.05.005 · Cited by 69 · see citing works
Kim, M., Kim, M., Kang, M., Yoo, H. J., Kim, M. S., Ahn, Y.-T., Sim, J.-H., Jee, S. H., & Lee, J. H. (2017) · Food & Function · doi:10.1039/c6fo00993j · Cited by 67 · see citing works
Self-citationGuo, X., Cao, X., Fang, X., Guo, A., & Li, E. (2021) · Food & Function · doi:10.1039/d0fo03423a · Cited by 67 · see citing works
Chen, Y., Yu, L., Qiao, N., Xiao, Y., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2020) · Foods · doi:10.3390/foods9101366 · Cited by 64 · see citing works
Probiotic Characteristics of Lactobacillus curvatus DN317, a Strain Isolated from Chicken Ceca
Zommiti, M., Connil, N., Hamida, J. B., & Ferchichi, M. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9301-y · Cited by 67 · see citing works
Zhu, G., Ma, F., Wang, G., Wang, Y., Zhao, J., Zhang, H., & Chen, W. (2018) · Food & Function · doi:10.1039/c8fo00100f · Cited by 62 · see citing works
Lactobacillus acidophilus NS1 attenuates diet-induced obesity and fatty liver
Park, S. S., Lee, Y., Song, S., Kim, B., Kang, H., Oh, S., & Kim, E. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0592 · Cited by 62 · see citing works
Cai, H., Wen, Z., Li, X., Meng, K., & Yang, P. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10620-0 · Cited by 62 · see citing works
Zhao, D., Zhu, H., Gao, F., Qian, Z., Mao, W., Yin, Y., Tan, J., & Chen, D. (2020) · Food & Function · doi:10.1039/d0fo00180e · Cited by 62 · see citing works
Shirouchi, B., Nagao, K., Umegatani, M., Shiraishi, A., Morita, Y., Kai, S., Yanagita, T., Ogawa, A., Kadooka, Y., & Satô, M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002245 · Cited by 61 · see citing works
Lee, J., Jang, J., Kwon, M., Lim, S. K., Kim, N., Lee, J., Park, H. K., Yun, M., Shin, M., Jo, H. E., et al. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800329 · Cited by 62 · see citing works
Kobyliak, N. M., Falalyeyeva, T. M., Bodnar, P., & Beregova, T. V. (2016) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-016-9230-1 · Cited by 56 · see citing works
Wang, Y., Jin, C., Wang, D., Zhou, J., Yang, G., Shao, K., Wang, Q., & Jin, Y. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124639 · Cited by 55 · see citing works
Yue, B., Zong, G., Tao, R., Wei, Z., & Lu, Y. (2022) · Phytotherapy Research · doi:10.1002/ptr.7607 · Cited by 53 · see citing works
Catry, É., Pachikian, B. D., Salazar, N., Neyrinck, A. M., Cani, P. D., & Delzenne, N. M. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.04.004 · Cited by 53 · see citing works
Núñez, I. N., Galdeano, C. M., de LeBlanc, A. D. M., & Perdigón, G. (2014) · Nutrition · doi:10.1016/j.nut.2014.03.025 · Cited by 53 · see citing works
Long, X., Zeng, X., Tan, F., Yi, R., Pan, Y., Zhou, X., Mu, J., & Zhao, X. (2020) · Food & Function · doi:10.1039/d0fo00519c · Cited by 50 · see citing works
Won, S., Chen, S., Lee, S. Y., Lee, K. E., Park, K. W., & Yoon, J. (2020) · Nutrients · doi:10.3390/nu12123703 · Cited by 51 · see citing works
Protective Role of Probiotic Supplements in Hepatic Steatosis: A Rat Model Study
Azarang, A., Farshad, O., Ommati, M. M., Jamshidzadeh, A., Heidari, R., Abootalebi, S. N., & Gholami, A. (2020) · BioMed Research International · doi:10.1155/2020/5487659 · Cited by 50 · see citing works
Shin, J., Nam, M. H., Lee, H.-R., Lee, J., Kim, H., Chung, M.-J., & Seo, J. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1481-4 · Cited by 49 · see citing works
The gut microbiota–brain axis: Role of the gut microbial metabolites of dietary food in obesity
Song, X., Wang, L., Liu, Y., Zhang, X., Weng, P., Liu, L., Zhang, R., & Wu, Z. (2022) · Food Research International · doi:10.1016/j.foodres.2022.110971 · Cited by 56 · see citing works
Li, X., Yi, J., He, J., Dong, J., & Duan, X. (2024) · LWT · doi:10.1016/j.lwt.2024.115740 · Cited by 48 · see citing works
Xie, M., Hao, Q., Olsen, R. E., Ringø, E., Yang, Y., Zhang, Z., Ran, C., & Zhou, Z. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101046 · Cited by 47 · see citing works
Chen, Y., Yang, N., Lin, Y., Ho, S., Li, K., Lin, J., Liu, J., & Chen, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-23844-y · Cited by 47 · see citing works
Huo, Y., Lu, X., Wang, X., Wang, X., Chen, L., Guo, H., Zhang, M., & Li, Y. (2020) · Molecules · doi:10.3390/molecules25071490 · Cited by 45 · see citing works
Probiotic strains and mechanistic insights for the treatment of type 2 diabetes
Hampe, C. S., & Roth, C. L. (2017) · Endocrine · doi:10.1007/s12020-017-1433-z · Cited by 45 · see citing works
Chiu, C., Chang, T.-C., Liu, S., & Chiang, M. (2017) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.11.015 · Cited by 44 · see citing works
Gut microbiota and obesity: Involvement of the adipose tissue
Guida, S., & Venema, K. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.02.014 · Cited by 43 · see citing works
Zafar, H., Ain, N. U., Alshammari, A., Alghamdi, S., Raja, H., Ali, A., Siddique, A., Tahir, S. D., Akbar, S., Arif, M., et al. (2022) · Nutrients · doi:10.3390/nu14081654 · Cited by 41 · see citing works
Microbial Impact on Host Metabolism: Opportunities for Novel Treatments of Nutritional Disorders?
Plovier, H., & Cani, P. D. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0002-2016 · Cited by 40 · see citing works
Zhou, S.-S., Au-Yeung, K. K. W., Yip, K.-M., Ye, R., Zhao, Z., Mao, Q., Xu, J., Chen, H., & Li, S. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.11.021 · Cited by 41 · see citing works
Moon, Y., Baik, S., & Cha, Y. (2014) · Nutrients · doi:10.3390/nu6031016 · Cited by 41 · see citing works
Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic Syndrome
Silva, L. H. A. C., Galvão, J. G. F. M., da Silva, J. S. D. F., de Sales-Neto, J. M., & Rodrigues‐Mascarenhas, S. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00341 · Cited by 40 · see citing works
Kobyliak, N. M., Falalyeyeva, T. M., Virchenko, O., Mykhalchyshyn, G., Bodnar, P., NIa, S., Yankovsky, D., Beregova, T. V., & Остапченко, Л. І. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0451-2 · Cited by 40 · see citing works
Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology
Jin, K., Huang, Y. B., Che, H., & Wu, Y. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70080 · Cited by 43 · see citing works
The development of probiotics therapy to obesity: a therapy that has gained considerable momentum
Kang, Y., & Cai, Y. (2018) · Hormones · doi:10.1007/s42000-018-0003-y · Cited by 38 · see citing works
Gut microbiota and obesity: an overview of microbiota to microbial-based therapies
Sheykhsaran, E., Abbasi, A., Leylabadlo, H. E., Sadeghi, J., Mehri, S., Mazraeh, F. N., Feizi, H., & Baghi, H. B. (2022) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2021-141311 · Cited by 38 · see citing works
Probiotics: Supplements, Food, Pharmaceutical Industry
Putta, S., Yarla, N. S., Lakkappa, D. B., Imandi, S. B., Malla, R. R., Amajala, K. C., Chari, B. P. V., Saka, S., Vechalapu, R. R., Kamal, M. A., et al. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814625-5.00002-9 · Cited by 37 · see citing works
Yang, M., Zheng, J., Zong, X., Yang, X., Zhang, Y., Man, C., & Jiang, Y. (2021) · Nutrients · doi:10.3390/nu13113989 · Cited by 37 · see citing works
Musazadeh, V., Anilou, M. M., Vajdi, M., Karimi, A., Ahrabi, S. S., & Dehghan, P. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1121541 · Cited by 36 · see citing works
Wu, H., Mu, C., Li, X., Fan, W., Shen, L., & Zhu, W. (2024) · Advanced Science · doi:10.1002/advs.202400058 · Cited by 35 · see citing works
Fabersani, E., Marquez, A., Russo, M., Ross, R., Torres, S., Fontana, C. A., Puglisi, E., Medina, R. B., & Gauffin-Cano, P. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718564 · Cited by 34 · see citing works
Fareez, I. M., Lim, S. M., Lim, F. T., Mishra, R. K., & Ramasamy, K. (2016) · Journal of Food Process Engineering · doi:10.1111/jfpe.12458 · Cited by 32 · see citing works
Li, Y., Shi, G., Han, Y., Shang, H., Li, H., Liang, W. P., Zhao, W., Bai, L., & Qin, C. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02490-8 · Cited by 33 · see citing works
Intervention with kimchi microbial community ameliorates obesity by regulating gut microbiota
Park, S., Kwon, S. J., Cho, K., Seo, S.-H., Kim, E., Unno, T., Bok, S., Park, D.-H., & Son, H.-S. (2020) · The Journal of Microbiology · doi:10.1007/s12275-020-0266-2 · Cited by 31 · see citing works
Self-citationChleilat, F., Schick, A., Deleemans, J. M., Ma, K., Alukic, E., Wong, J., Tuplin, E. W. N., Nettleton, J. E., & Reimer, R. A. (2021) · The FASEB Journal · doi:10.1096/fj.202100198rr · Cited by 31 · see citing works
Gut macrobiotic and its metabolic pathways modulate cardiovascular disease
Zhu, J., Lyu, J., Zhao, R., Liu, G., & Wang, S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1272479 · Cited by 30 · see citing works
Obesity, Asthma, and the Microbiome
Cho, Y., & Shore, S. A. (2016) · Physiology · doi:10.1152/physiol.00045.2015 · Cited by 30 · see citing works
Zhao, H. J., Luo, Y., Zhang, Y., Chen, X., Wang, H., Guo, D., & Wu, Z. (2019) · Marine Life Science & Technology · doi:10.1007/s42995-019-00005-2 · Cited by 30 · see citing works
Fu, H., Liu, H., Ge, Y., Chen, Y., Tan, P., Bai, J., Dai, Z., Yang, Y., & Wu, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130669 · Cited by 30 · see citing works
Carreras, N. L., Martorell, P., Chenoll, E., Genovés, S., Ramón, D., & Aleixandre, A. (2018) · Beneficial Microbes · doi:10.3920/bm2017.0141 · Cited by 30 · see citing works
- Authors
- Yoo, S., Kim, Y., Park, D., Jung, U., Jeon, S., Ahn, Y., Huh, C., McGregor, R., & Choi, M. S.
- Affiliations
- National Research Foundation of Korea (KR)
- Kyungpook National University (KR)
- Department of Biological Science Seoul National University Daehak‐dong, Gwanak‐gu, Seoul 151‐742 Seoul Republic of Korea
- Korea Yakult (South Korea) (KR)
- University of Auckland (NZ)
- Corresponding author
- Choi, Myung Sook
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2013-06-11
- Volume
- 21
- Issue
- 12
- Pages
- 2571-2578
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W1583400374
- Cited by
- 230
- References
- 39
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 24 · 2023: 26 · 2022: 23 · 2021: 19 · 2020: 24 · 2019: 15 · 2018: 24 · 2017: 13 · 2016: 19 · 2015: 8 · 2014: 8 · 2013: 2
- FWCI
- 18.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- Lactobacillus plantarum, Lactobacillus curvatus, multi-strain probiotics, diet-induced obesity, hepatic lipid metabolism, high-fat high-cholesterol diet, hepatic triglycerides, fatty acid synthesis, fatty acid oxidation, hepatic lipid accumulation
- MeSH terms
- Adipose Tissue, Animals, Anti-Inflammatory Agents, Cholesterol, Cholesterol, Dietary, Lactobacillus, Liver, Male, Mice, Inbred C57BL, Obesity, Triglycerides, Tumor Necrosis Factor-alpha, Interleukin-6, Gene Expression, Probiotics, Lipogenesis, Mice, Interleukin-1beta, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review