Growth of white matter in the adolescent brain: Myelin or axon?

Paus, Tomáš

doi:10.1016/j.bandc.2009.06.002

Cited by 424Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesNeural and Behavioral Psychology Studies

Growth of white matter in the adolescent brain: Myelin or axon?

Paus, Tomáš·2010·Brain and Cognition

DOI 10.1016/j.bandc.2009.06.002

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Abstract

White matter occupies almost half of the human brain. It contains axons connecting spatially segregated modules and, as such, it is essential for the smooth flow of information in functional networks. Structural maturation of white matter continues during adolescence, as reflected in age-related changes in its volume, as well as in its microstructure. Here I review recent observations obtained with magnetic resonance imaging in typically developing adolescents and point out some of the known variations in structural properties of white matter vis-à-vis brain function in health and disease. I conclude by re-focusing the interpretations of MR-based studies of white matter from myelin to axon.

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There are corresponding increases in white matter during adolescence, thought to reflect increased myelination and axonal diameter, resulting in increased efficiency of impulse transduction.
“There are corresponding increases in white matter, which is thought to reflect increased myelination and axonal diameter, resulting in increased efficiency of impulse transduction (Paus, 2010).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Paus, 2010
Animal tracing studies suggest that tracts between the striatum and prefrontal regions are likely afferent, providing input to the striatum.
“However, based on animal tracing studies, it is likely that the tracts between the striatum and prefrontal regions are afferent (i.e., providing input to the striatum) (58), suggesting the hypothesis that the reduction in impatience is due to top-down control.”
From Adolescent impatience decreases with increased frontostriatal connectivity (2015) · cites this paper as [58]

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Authors: Paus, T.
Affiliations: Montreal Neurological Institute and Hospital (CA)
Corresponding author: Paus, Tomáš
ORCID: Paus, Tomáš
Venue: Brain and Cognition
Publisher: Elsevier BV
Published: 2010-02
Volume: 72
Issue: 1
Pages: 26-35
ISSN: 0278-2626 (ISSN-L)
DOI: 10.1016/j.bandc.2009.06.002
OpenAlex: W2020823327
Cited by: 424
References: 87
Citations by year: 2026: 11 · 2025: 11 · 2024: 19 · 2023: 23 · 2022: 28 · 2021: 14 · 2020: 29 · 2019: 23 · 2018: 29 · 2017: 31 · 2016: 27 · 2015: 43 · 2014: 24 · 2013: 37 · 2012: 20
FWCI: 3.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain and Cognition (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: white matter, adolescent brain development, myelination, axons, white matter microstructure, brain maturation, functional networks, white matter volume
MeSH terms: Adolescent, Animals, Axons, Brain, Humans, Myelin Sheath, Nerve Fibers, Myelinated, Neural Pathways

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Growth of white matter in the adolescent brain: Myelin or axon?

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