Growth of white matter in the adolescent brain: role of testosterone and androgen receptor
Open accessAbstract
The growth of white matter during human adolescence shows a striking sexual dimorphism; the volume of white matter increases with age slightly in girls and steeply in boys. Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter. In a large sample of typically developing adolescents ( n = 408, 204 males), we used magnetic resonance imaging and acquired T1-weighted and magnetization transfer ratio (MTR) images. We also measured plasma levels of testosterone and genotyped a functional polymorphism in the AR gene, namely the number of CAG repeats in exon 1 believed to be inversely proportional to the AR transcriptional activity. We found that the testosterone-related increase of white-matter volume was stronger in male adolescents with the lower versus higher number of CAG repeats in the AR gene, with testosterone explaining, respectively, 26 and 8% of variance in the volume. The MTR results suggest that this growth is not related to myelination; the MTR decreased with age in male adolescents. We speculate that testosterone affects axonal caliber rather than the thickness of the myelin sheath.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Statistical Methods for Psychology.
Gudgeon, A. C., & Howell, D. C. (1994) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348956 · Cited by 8,277 · see citing works
A self‐report measure of pubertal status: Reliability, validity and initial norms
Petersen, A. C., Crockett, L., Richards, M., & Boxer, A. (1988) · Journal of Youth and Adolescence · doi:10.1007/bf01537962 · Cited by 3,129 · see citing works
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
Spada, A. L., Wilson, E. M., Lubahn, D. B., Harding, A., & Fischbeck, K. (1991) · Nature · doi:10.1038/352077a0 · Cited by 2,801 · see citing works
Mapping brain maturation and cognitive development during adolescence
Paus, T. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.12.008 · Cited by 1,348 · see citing works
Self-citationSexual dimorphism of brain developmental trajectories during childhood and adolescence
Lenroot, R. K., Gogtay, N., Greenstein, D. K., Wells, E. M., Wallace, G. L., Clasen, L. S., Blumenthal, J. D., Lerch, J., Zijdenbos, A. P., Evans, A. C., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.053 · Cited by 1,309 · see citing works
Södergard, R., Bäckström, T., Shanbhag, V., & Carstensen, H. (1982) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(82)90038-3 · Cited by 1,080 · see citing works
Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain
Schmierer, K., Scaravilli, F., Altmann, D. R., Barker, G. J., & Miller, D. H. (2004) · Annals of Neurology · doi:10.1002/ana.20202 · Cited by 777 · see citing works
Sex Differences in Brain Maturation during Childhood and Adolescence
De Bellis, M. D. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.552 · Cited by 728 · see citing works
Neurofilament gene expression: a major determinant of axonal caliber.
Hoffman, P. N., Cleveland, D. W., Griffin, J. W., Landes, P. W., Cowan, N. J., & Price, D. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3472 · Cited by 719 · see citing works
Marked loss of myelinated nerve fibers in the human brain with age
Marner, L., Nyengaard, J., Tang, Y., & Pakkenberg, B. (2003) · The Journal of comparative neurology · doi:10.1002/cne.10714 · Cited by 625 · see citing works
Affective and psychotic symptoms associated with anabolic steroid use
Pope, H. G., & Katz, D. L. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.4.487 · Cited by 492 · see citing works
The DISC Predictive Scales (DPS): Efficiently Screening for Diagnoses
Lucas, C. P., Zhang, H., Fisher, P. W., Shaffer, D., Regier, D. A., Narrow, W. E., Bourdon, K. H., Dulcan, M. K., CANINO, G. J., Rubio‐Stipec, M., et al. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200104000-00013 · Cited by 370 · see citing works
Magnetic Resonance Imaging of Myelin
Laule, C., Vavasour, I. M., Kolind, S. H., Li, D. K. B., Traboulsee, T. L., Moore, G. R. W., & MacKay, A. L. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.004 · Cited by 334 · see citing works
Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation
Schmierer, K., Wheeler‐Kingshott, C. A. M., Tozer, D. J., Boulby, P. A., Parkes, H. G., Yousry, T. A., Scaravilli, F., Barker, G. J., Tofts, P. S., & Miller, D. H. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21487 · Cited by 281 · see citing works
Kucharczyk, W., Macdonald, P. M., Stanisz, G. J., & Henkelman, R. M. (1994) · Radiology · doi:10.1148/radiology.192.2.8029426 · Cited by 273 · see citing works
Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length
Irvine, R. A. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.2.267 · Cited by 263 · see citing works
Neuroactive steroids: State of the art and new perspectives
Melcangi, R. C., García‐Segura, L. M., & Mensah‐Nyagan, A. G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7403-5 · Cited by 232 · see citing works
Hsiao, P., Lin, D., Nakao, R., & Chang, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20229 · Cited by 221 · see citing works
Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport.
Marszalek, J. R., Williamson, T. L., Lee, M. K., Xu, Z., Hoffman, P. N., Bêcher, M. W., Crawford, T. O., & Cleveland, D. W. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.3.711 · Cited by 191 · see citing works
Perceptions of puberty: Adolescent, parent, and health care personnel.
Dorn, L. D., Susman, E. J., Nottelmann, E. D., Inoff‐Germain, G., & Chrousos, G. P. (1990) · Developmental Psychology · doi:10.1037/0012-1649.26.2.322 · Cited by 149 · see citing works
Pausová, Z., Paus, T., Abrahamowicz, M., Almerigi, J. B., Arbour, N., Bernard, M., Gaudet, D., Hanzalek, P., Hamet, P., Evans, A. C., et al. (2007) · Human Brain Mapping · doi:10.1002/hbm.20402 · Cited by 122 · see citing works
Self-citationPike, G. B. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910360117 · Cited by 119 · see citing works
Self-citationEkl�f, A.-C., Thurelius, A.-M., Garle, M., Rane, A., & Sj�qvist, F. (2003) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-003-0633-z · Cited by 116 · see citing works
New movements in neurofilament transport, turnover and disease
Barry, D. M., Millecamps, S., Julien, J., & Garcia, M. L. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.03.011 · Cited by 98 · see citing works
Spinal and bulbar muscular atrophy: a trinucleotide-repeat expansion neurodegenerative disease
Brooks, B. P., & Fischbeck, K. H. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)94497-s · Cited by 88 · see citing works
Rovira, À., Grivé, E., Pedraza, S., Rovira, À., & Alonso, J. (2001) · PubMed Central · Cited by 82 · see citing works
Neural Actions of Luteinizing Hormone and Human Chorionic Gonadotropin
Lei, Z. M., & Rao, C. V. (2001) · Seminars in Reproductive Medicine · doi:10.1055/s-2001-13917 · Cited by 67 · see citing works
Mechanisms of Disease: pharmacogenetics of testosterone therapy in hypogonadal men
Zitzmann, M. (2007) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0706 · Cited by 67 · see citing works
The physical basis of magnetization transfer imaging.
McGowan, J. C. (1999) · PubMed · Cited by 54 · see citing works
Matsumoto, A., Arai, Y., & Hyodo, S. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00495.x · Cited by 42 · see citing works
Androgen‐induced up‐regulation of tubulin isoforms in neuroblastoma cells
Butler, R. K., Leigh, P. N., & Gallo, J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00475.x · Cited by 40 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Why do many psychiatric disorders emerge during adolescence?
Paus, T., Keshavan, M., & Giedd, J. N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2513 · Cited by 3,123 · see citing works
Self-citationSomerville, L. H., Jones, R. M., & Casey, B. J. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.07.003 · Cited by 1,025 · see citing works
The role of puberty in the developing adolescent brain
Blakemore, S., Burnett, S., & Dahl, R. E. (2010) · Human Brain Mapping · doi:10.1002/hbm.21052 · Cited by 1,011 · see citing works
Imaging brain development: The adolescent brain
Blakemore, S.-J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.080 · Cited by 649 · see citing works
The development of brain white matter microstructure
Lebel, C., & Deoni, S. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.12.097 · Cited by 602 · see citing works
Back to the future: The organizational-activational hypothesis adapted to puberty and adolescence
Schulz, K. M., Molenda-Figueira, H. A., & Sisk, C. L. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.010 · Cited by 587 · see citing works
Sex differences in the adolescent brain
Lenroot, R., & Giedd, J. N. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2009.10.008 · Cited by 563 · see citing works
White matter development in adolescence: A DTI study
Asato, M. R., Terwilliger, R., Woo, J., & Luna, B. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp282 · Cited by 512 · see citing works
Pubertal development and behavior: hormonal activation of social and motivational tendencies
Forbes, E. E., & Dahl, R. E. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.10.007 · Cited by 494 · see citing works
Changes in Sleep as a Function of Adolescent Development
Colrain, I. M., & Baker, F. C. (2011) · Neuropsychology Review · doi:10.1007/s11065-010-9155-5 · Cited by 452 · see citing works
Adolescent Brain Development and the Risk for Alcohol and Other Drug Problems
Bava, S., & Tapert, S. F. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9146-6 · Cited by 443 · see citing works
Puberty and the human brain: insights into adolescent development
Vijayakumar, N., Op de Macks, Z., Shirtcliff, E. A., & Pfeifer, J. H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.06.004 · Cited by 437 · see citing works
Growth of white matter in the adolescent brain: Myelin or axon?
Paus, T. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.002 · Cited by 424 · see citing works
Self-citationLongitudinal changes in grey and white matter during adolescence
Giorgio, A., Watkins, K. E., Chadwick, M., James, S., Winmill, L., Douaud, G., De Stefano, N., Matthews, P. M., Smith, S. M., Johansen-Berg, H., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.08.003 · Cited by 394 · see citing works
Burnett, S., Sebastian, C., Cohen Kadosh, K., & Blakemore, S.-J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.011 · Cited by 391 · see citing works
Gender development and the human brain
Hines, M. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113654 · Cited by 378 · see citing works
Schumacher, M., Mattern, C., Ghoumari, A. M., Oudinet, J., Lière, P., Labombarda, F., Sitruk-Ware, R. L., Nicola, A. F. D., & Guennoun, R. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.09.004 · Cited by 353 · see citing works
Age of Onset of Schizophrenia: Perspectives From Structural Neuroimaging Studies
Gogtay, N., Vyas, N. S., Testa, R., Wood, S. J., & Pantelis, C. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr030 · Cited by 346 · see citing works
Brenhouse, H. C., & Andersen, S. L. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.013 · Cited by 340 · see citing works
Sexual differentiation of human behavior: Effects of prenatal and pubertal organizational hormones
Berenbaum, S. A., & Beltz, A. M. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.03.001 · Cited by 340 · see citing works
The Impact of Sex, Puberty, and Hormones on White Matter Microstructure in Adolescents
Herting, M. M., Maxwell, E. C., Irvine, C., & Nagel, B. J. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr246 · Cited by 331 · see citing works
Brain Development During Adolescence
Konrad, K., Firk, C., & Uhlhaas, P. J. (2013) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2013.0425 · Cited by 323 · see citing works
Review: magnetic resonance imaging of male/female differences in human adolescent brain anatomy
Giedd, J. N., Raznahan, A., Mills, K. L., & Lenroot, R. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-19 · Cited by 318 · see citing works
The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development
Schulz, K. M., & Sisk, C. L. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.036 · Cited by 316 · see citing works
Puberty and structural brain development in humans
Herting, M. M., & Sowell, E. R. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.003 · Cited by 305 · see citing works
Sex differences and the neurobiology of affective disorders
Rubinow, D. R., & Schmidt, P. J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0148-z · Cited by 274 · see citing works
Raznahan, A., Lee, Y., Stidd, R., Long, R., Greenstein, D., Clasen, L., Addington, A., Gogtay, N., Rapoport, J. L., & Giedd, J. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006025107 · Cited by 278 · see citing works
Adolescence as a vulnerable period to alter rodent behavior
Schneider, M. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1581-2 · Cited by 266 · see citing works
Changes in the adolescent brain and the pathophysiology of psychotic disorders
Keshavan, M. S., Giedd, J. N., Lau, J. Y. F., Lewis, D. A., & Paus, T. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00081-9 · Cited by 247 · see citing works
Self-citationWhite matter development during adolescence as shown by diffusion MRI
Schmithorst, V. J., & Yuan, W. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.005 · Cited by 249 · see citing works
Sleep and the transition to adolescence: a longitudinal study
Sadeh, A., Dahl, R. E., Shahar, G., & Rosenblat-Stein, S. (2009) · SLEEP · doi:10.1093/sleep/32.12.1602 · Cited by 243 · see citing works
Dong, H.-M., Margulies, D. S., Zuo, X., & Holmes, A. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024448118 · Cited by 240 · see citing works
Sex differences and structural brain maturation from childhood to early adulthood
Koolschijn, P. C. M. P., & Crone, E. A. (2013) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2013.02.003 · Cited by 234 · see citing works
Smith, A. R., Chein, J., & Steinberg, L. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.03.006 · Cited by 214 · see citing works
Sex steroids and connectivity in the human brain: A review of neuroimaging studies
Peper, J. S., van den Heuvel, M. P., Mandl, R. C. W., Pol, H. E. H., & van Honk, J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.004 · Cited by 209 · see citing works
Sex steroids and brain structure in pubertal boys and girls: a mini-review of neuroimaging studies
Peper, J. S., Pol, H. E. H., Crone, E. A., & van Honk, J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.014 · Cited by 204 · see citing works
Sex differences in the growth of white matter during adolescence
Perrin, J. S., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Veillette, S., Pausova, Z., & Paus, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.023 · Cited by 197 · see citing works
Self-citationTestosterone-Related Cortical Maturation Across Childhood and Adolescence
Nguyen, T., McCracken, J. T., Ducharme, S., Botteron, K. N., Mahabir, M., Johnson, W., Israël, M., Evans, A. C., Karama, S., & for the Brain Development Cooperative Group (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs125 · Cited by 189 · see citing works
Opposing Brain Differences in 16p11.2 Deletion and Duplication Carriers
Qureshi, A. Y., Mueller, S., Snyder, A. Z., Mukherjee, P., Berman, J. I., Roberts, T. P. L., Nagarajan, S. S., Spiro, J. E., Chung, W. K., Sherr, E. H., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1366-14.2014 · Cited by 183 · see citing works
Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data
Uban, K. A., Horton, M. K., Jacobus, J., Heyser, C., Thompson, W. K., Tapert, S. F., Madden, P. A. F., & Sowell, E. R. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.03.005 · Cited by 175 · see citing works
Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Piekarski, D. J., Johnson, C. M., Boivin, J. R., Thomas, A. W., Lin, W. C., Delevich, K., M. Galarce, E., & Wilbrecht, L. (2017) · Brain Research · doi:10.1016/j.brainres.2016.08.042 · Cited by 175 · see citing works
The relationship between puberty and social emotion processing
Goddings, A., Burnett Heyes, S., Bird, G., Viner, R. M., & Blakemore, S. (2012) · Developmental Science · doi:10.1111/j.1467-7687.2012.01174.x · Cited by 169 · see citing works
Scherf, K. S., Behrmann, M., & Dahl, R. E. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.016 · Cited by 166 · see citing works
Shaping of the Female Human Brain by Sex Hormones: A Review
Rehbein, E., Hornung, J., Poromaa, I. S., & Derntl, B. (2020) · Neuroendocrinology · doi:10.1159/000507083 · Cited by 152 · see citing works
Barth, C., Crestol, A., de Lange, A. G., & Galea, L. A. M. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00224-3 · Cited by 159 · see citing works
Adolescent brain development in normality and psychopathology
Luciana, M. M. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000643 · Cited by 157 · see citing works
Sex differences in adolescent white matter architecture
Bava, S., Boucquey, V., Goldenberg, D., Thayer, R. E., Ward, M. E., Jacobus, J., & Tapert, S. F. (2010) · Brain Research · doi:10.1016/j.brainres.2010.12.051 · Cited by 144 · see citing works
Ladouceur, C. D., Peper, J. S., Crone, E. A., & Dahl, R. E. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.06.002 · Cited by 143 · see citing works
A Review of the Status of Brain Structure Research in Transsexualism
Guillamón, A., Junqué, C., & Gómez‐Gil, E. (2016) · Archives of Sexual Behavior · doi:10.1007/s10508-016-0768-5 · Cited by 135 · see citing works
Paus, T., Nawaz-Khan, I., Leonard, G. T., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Susman, E. J., Veillette, S., & Pausová, Z. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.08.004 · Cited by 137 · see citing works
Self-citationSex hormone activity in alcohol addiction: Integrating organizational and activational effects
Lenz, B., Müller, C. P., Stoessel, C., Sperling, W., Biermann, T., Hillemacher, T., Bleich, S., & Kornhuber, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.11.001 · Cited by 136 · see citing works
Sex differences in the human brain
Paus, T. (2010) · Progress in brain research · doi:10.1016/b978-0-444-53630-3.00002-6 · Cited by 134 · see citing works
Self-citationDollé, J.-P., Jaye, A., Anderson, S. A., Ahmadzadeh, H., Shenoy, V. B., & Smith, D. H. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2017.11.001 · Cited by 128 · see citing works
Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss
Bennett, M. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.003 · Cited by 126 · see citing works
The young brain and concussion: Imaging as a biomarker for diagnosis and prognosis
Toledo, E., Lebel, A., Becerra, L. R., Minster, A., Linnman, C., Maleki, N., Dodick, D. W., & Borsook, D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.03.007 · Cited by 124 · see citing works
Abnormal Anatomical Connectivity between the Amygdala and Orbitofrontal Cortex in Conduct Disorder
Passamonti, L., Fairchild, G., Fornito, A., Goodyer, I. M., Nimmo-Smith, I., Hagan, C. C., & Calder, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048789 · Cited by 123 · see citing works
Ziegler, G., Hauser, T. U., Moutoussis, M., Bullmore, E. T., Goodyer, I. M., Fonagy, P., Jones, P. B., Lindenberger, U., & Dolan, R. J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0394-3 · Cited by 123 · see citing works
Jernigan, T. L., Baaré, W. F. C., Stiles, J., & Madsen, K. S. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53884-0.00019-1 · Cited by 118 · see citing works
Knickmeyer, R. C., Styner, M. A., Short, S. J., Lubach, G. R., Kang, C., Hamer, R. M., Coe, C. L., & Gilmore, J. H. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp166 · Cited by 113 · see citing works
Beltz, A., & Moser, J. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14255 · Cited by 98 · see citing works
Age- and gender-related changes in the normal human brain using hybrid diffusion imaging (HYDI)
Wu, Y., Field, A. S., Whalen, P. J., & Alexander, A. L. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.067 · Cited by 108 · see citing works
Brouwer, R. M., Mandl, R. C. W., Schnack, H. G., van Soelen, I. L. C., van Baal, G. C., Peper, J. S., Kahn, R. S., Boomsma, D. I., & Pol, H. E. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032316 · Cited by 107 · see citing works
Ladouceur, C. D. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00065 · Cited by 104 · see citing works
Could sex differences in white matter be explained by g ratio?
Paus, T. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.014.2009 · Cited by 98 · see citing works
Self-citationAdolescent brain development, risk-taking and vulnerability to addiction
Dayan, J., Bernard, A., Olliac, B., Mailhes, A.-S., & Kermarrec, S. (2010) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2010.08.007 · Cited by 101 · see citing works
Epigenetic mechanisms in pubertal brain maturation
Morrison, K. E., Rodgers, A. B., Morgan, C. P., & Bale, T. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.014 · Cited by 90 · see citing works
Marečková, K., Weinbrand, Z., Chakravarty, M. M., Lawrence, C., Aleong, R., Leonard, G. T., Perron, M., Pike, G. B., Richer, L., Veillette, S., et al. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.09.004 · Cited by 90 · see citing works
Self-citationPohl, K. M., Sullivan, E. V., Rohlfing, T., Chu, W., Kwon, D., Nichols, B. N., Zhang, Y., Brown, S. A., Tapert, S. F., Cummins, K., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.01.061 · Cited by 85 · see citing works
Role of puberty in multiple sclerosis risk and course
Chitnis, T. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.03.014 · Cited by 84 · see citing works
Testosterone in the brain: Neuroimaging findings and the potential role for neuropsychopharmacology
Höfer, P., Lanzenberger, R. R., & Kasper, S. F. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.04.013 · Cited by 83 · see citing works
White matter development in the early stages of psychosis
Peters, B. D., & Karlsgodt, K. H. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.021 · Cited by 79 · see citing works
Genc, S., Smith, R. E., Malpas, C. B., Anderson, V., Nicholson, J., Efron, D., Sciberras, E., Seal, M., & Silk, T. (2018) · bioRxiv · doi:10.1016/j.neuroimage.2018.08.043 · Cited by 84 · see citing works
Adolescent brain development and contextual influences: a decade in review
Galván, A. (2021) · Journal of Research on Adolescence · doi:10.1111/jora.12687 · Cited by 77 · see citing works
Neurophysiological changes with age probed by inverse modeling of EEG spectra
van Albada, S. J., Kerr, C. C., Chiang, A. K., RENNIE, C. J., & Robinson, P. A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.09.021 · Cited by 77 · see citing works
Adolescent sleep and the foundations of prefrontal cortical development and dysfunction
Anastasiades, P. G., de Vivo, L., Bellesi, M., & Jones, M. W. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102338 · Cited by 83 · see citing works
Handedness, motor skills and maturation of the corticospinal tract in the adolescent brain
Hervé, P., Leonard, G. T., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Veillette, S., Pausová, Z., & Paus, T. (2009) · Human Brain Mapping · doi:10.1002/hbm.20734 · Cited by 75 · see citing works
Self-citationTestosterone Effects on the Brain in Transgender Men
Burke, S., Manzouri, A., Dhejne, C., Bergström, K., Arver, S., Feusner, J. D., & Savic, I. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx054 · Cited by 77 · see citing works
Rametti, G., Carrillo, B., Gómez‐Gil, E., Junqué, C., Zubiaurre‐Elorza, L., Segovia, S., Gómez, Á., Karádi, K., & Guillamón, A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.019 · Cited by 75 · see citing works
Holliday, E. D., & Gould, T. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.003 · Cited by 75 · see citing works
Gabriel, E. T., Oberger, R., Schmoeger, M., Deckert, M., Vockh, S., Auff, E., & Willinger, U. (2019) · Psychological Research · doi:10.1007/s00426-019-01263-6 · Cited by 75 · see citing works
Fishman, I., Datko, M., Cabrera, Y., Carper, R. A., & Müller, R. (2015) · Annals of Neurology · doi:10.1002/ana.24533 · Cited by 69 · see citing works
Sex Differences in the Contributions of Visceral and Total Body Fat to Blood Pressure in Adolescence
Pausova, Z., Mahboubi, A., Abrahamowicz, M., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Gaudet, D., & Paus, T. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.180372 · Cited by 70 · see citing works
Self-citationvan Hemmen, J., Saris, I. M. J., Cohen‐Kettenis, P. T., Veltman, D. J., Pouwels, P. J. W., & Bakker, J. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw156 · Cited by 71 · see citing works
Desrivières, S., Lourdusamy, A., Tao, C., Toro, R., Jia, T., Loth, E., Medina, L. M., Kepa, A., Fernandes, A. R., Ruggeri, B., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.197 · Cited by 69 · see citing works
Self-citationAxon diameter and axonal transport: In vivo and in vitro effects of androgens
Pesaresi, M., Soon-Shiong, R., French, L., Kaplan, D., Miller, F., & Paus, T. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.048 · Cited by 73 · see citing works
Self-citationBrain volumes and Val66Met polymorphism of the BDNF gene: local or global effects?
Toro, R., Marie Chupin, A., Garnero, L., Leonard, G. T., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Veillette, S., Pausová, Z., et al. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0203-y · Cited by 70 · see citing works
Self-citationDouet, V., Chang, L., Cloak, C., & Ernst, T. (2013) · Brain Imaging and Behavior · doi:10.1007/s11682-013-9260-1 · Cited by 65 · see citing works
The effects of puberty on white matter development in boys
Menzies, L. A., Goddings, A., Whitaker, K. J., Blakemore, S., & Viner, R. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.10.002 · Cited by 64 · see citing works
Williams, O. A., An, Y., Beason‐Held, L. L., Huo, Y., Ferrucci, L., Landman, B. A., & Resnick, S. M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.12.009 · Cited by 64 · see citing works
White matter as a transport system
Paus, T., Pesaresi, M., & French, L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.055 · Cited by 59 · see citing works
Self-citationWolstenholme, J. T., Mahmood, T., Harris, G. M., Abbas, S., & Miles, M. F. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00307 · Cited by 61 · see citing works
Testosterone Trajectories and Reference Ranges in a Large Longitudinal Sample of Male Adolescents
Khairullah, A., Cousino Klein, L., Ingle, S. M., May, M. T., Whetzel, C. A., Susman, E. J., & Paus, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108838 · Cited by 60 · see citing works
Self-citationChildhood adversity, depression, age and gender effects on white matter microstructure: a DTI study
Ugwu, I., Amico, F., Carballedo, A., Fagan, A. J., & Frodl, T. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0769-x · Cited by 60 · see citing works
Bender, A. R., & Raz, N. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.001 · Cited by 60 · see citing works
Gender Influence on White Matter Microstructure: A Tract-Based Spatial Statistics Analysis
Kanaan, R. A., Chaddock, C., Allin, M., Picchioni, M. M., Daly, E., Shergill, S. S., & McGuire, P. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091109 · Cited by 59 · see citing works
How environment and genes shape the adolescent brain
Paus, T. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.04.004 · Cited by 59 · see citing works
Self-citationCortical morphology in children with alcohol‐related neurodevelopmental disorder
Rajaprakash, M., Chakravarty, M. M., Lerch, J. P., & ROVET, J. F. (2013) · Brain and Behavior · doi:10.1002/brb3.191 · Cited by 59 · see citing works
Cohort Profile: The Saguenay Youth Study (SYS)
Pausová, Z., Paus, T., Abrahamowicz, M., Bernard, M., Gaudet, D., Leonard, G. T., Peron, M., Pike, G. B., Richer, L., Séguin, J. R., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw023 · Cited by 58 · see citing works
Self-citationWhite matter changes in paediatric multiple sclerosis and monophasic demyelinating disorders
Longoni, G., Brown, R. A., MomayyezSiahkal, P., Elliott, C., Narayanan, S., Bar‐Or, A., Marrie, R. A., Yeh, E. A., Filippi, M., Banwell, B., et al. (2017) · Brain · doi:10.1093/brain/awx041 · Cited by 59 · see citing works
Puberty differentially predicts brain maturation in male and female youth: A longitudinal ABCD Study
Beck, D., Ferschmann, L., MacSweeney, N., Norbom, L. B., Wiker, T., Aksnes, E. R., Karl, V., Dégeilh, F., Holm, M. C., Mills, K. L., et al. (2023) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2023.101261 · Cited by 57 · see citing works
- Authors
- Perrin, J. S., Hervé, P.-Y., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Veillette, S., Pausova, Z., & Paus, T.
- Affiliations
- University of Nottingham (GB)
- Montreal Neurological Institute and Hospital (CA)
- Cégep de Jonquière (CA)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-09-17
- Volume
- 28
- Issue
- 38
- Pages
- 9519-9524
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6671132
- OpenAlex
- W2026062838
- Cited by
- 331
- References
- 31
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 21 · 2019: 18 · 2018: 19 · 2017: 15 · 2016: 23 · 2015: 17 · 2014: 24 · 2013: 35 · 2012: 22
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Constellation (Université du Québec à Chicoutimi) (submittedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Heart And Stroke Foundation Of Quebec
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- adolescence, testosterone, androgen receptor, sexual dimorphism, CAG repeat polymorphism, magnetization transfer ratio, myelination, axonal caliber, brain development, sex differences
- MeSH terms
- Adolescent, Aging, Brain, Child, Female, Humans, Magnetic Resonance Imaging, Male, Myelin Sheath, Nerve Fibers, Myelinated, Neural Pathways, Polymorphism, Genetic, Receptors, Androgen, Sex Characteristics, Testosterone, Trinucleotide Repeats, Cell Size
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
