The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Functions of Astrocytes and their Potential As Therapeutic Targets
Open accessAbstract
SummaryAstrocytes are often referred to, and historically have been regarded as, support cells of the mammalian CNS. Work over the last decade suggests otherwise—that astrocytes may in fact play a more active role in higher neural processing than previously recognized. Because astrocytes can potentially serve as novel therapeutic targets, it is critical to understand how astrocytes execute their diverse supportive tasks while maintaining neuronal health. To that end, this review focuses on the supportive roles of astrocytes, a line of study relevant to essentially all acute and chronic neurological diseases, and critically re-evaluates our concepts of the functional properties of astrocytes and relates these functions and properties to the intricate morphology of these cells.
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Tripartite synapses: astrocytes process and control synaptic information
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β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
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Uniquely Hominid Features of Adult Human Astrocytes
Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488
Self-citationLong-term potentiation depends on release of d-serine from astrocytes
Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389
New roles for astrocytes: redefining the functional architecture of the brain.
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“The brains of smaller mammalian creatures, naturally, have a smaller number of cells; and the ratio of astrocytes to neurons also declines.(3) The term astrocyte derives from a combination of a Greek word for star (astron; plural, astra) and the scientific word for cell (cyte, which is in turn derived from the Greek w…”
Self-citationBiochemistry of exercise-induced metabolic acidosis
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The tripartite synapse: roles for gliotransmission in health and disease
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Physiological Roles of Aquaporin-4 in Brain
Nagelhus, E. A., & Ottersen, O. P. (2013) · Physiological Reviews · doi:10.1152/physrev.00011.2013 · Cited by 766
Is Alzheimer’s disease a type 3 diabetes? A critical appraisal
Kandimalla, R., Thirumala, V., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.018 · Cited by 621
Inflammation, glutamate, and glia: a trio of trouble in mood disorders
Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584
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Metadata
- Authors
- Kimelberg, H. K., & Nedergaard, M.
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 7
- Issue
- 4
- Pages
- 338-353
- ISSN
- 1878-7479 (ISSN-L)
- OpenAlex
- W2091497743
- Cited by
- 408
- References
- 9
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
