Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury*

Singer, Pierre; Theilla, Myriam; Fisher, Haran; Gibstein, Lilly; Grozovski, Elad; Cohen, Jonathan

doi:10.1097/01.ccm.0000206111.23629.0a

Cited by 393Clinical Nutrition and GastroenterologyRespiratory Support and MechanismsNosocomial Infections in ICU

Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury*

Singer, Pierre, Theilla, Myriam, Fisher, Haran, Gibstein, Lilly, Grozovski, Elad, Cohen, Jonathan·2006·Critical Care Medicine

DOI 10.1097/01.ccm.0000206111.23629.0a

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Abstract

OBJECTIVE: To explore the effects of an enteral diet enriched with eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and antioxidants on the respiratory profile and outcome of patients with acute lung injury. DESIGN: Single-center, prospective, randomized, controlled, unblinded study. SETTING: General intensive care department of a tertiary-care, university-affiliated hospital. PATIENTS: A total of 100 patients with acute lung injury, diagnosed according to the American-European Consensus Conference on ARDS. INTERVENTIONS: Patients were randomized to receive the standard isonitrogenous, isocaloric enteral diet or the standard diet supplemented with EPA and GLA for 14 days. MEASUREMENTS AND MAIN RESULTS: Patient demographics, Acute Physiology and Chronic Health Evaluation II score, and type of admission were noted at admission. Compared with baseline oxygenation (EPA + GLA group vs. control group), by days 4 and 7, patients receiving the EPA + GLA diet showed significant improvement in oxygenation (PaO(2)/FIO(2), 317.3 +/- 99.5 vs. 214.3 +/- 56.4 and 296.5 +/- 165.3 vs. 236.3 +/- 79.8, respectively; p < .05). Compliance was significantly higher in the EPA + GLA group observed at day 7 (55.1 +/- 46.5 vs. 35.2 +/- 20.0 mL/mbar, p < .05). No significant difference was found in nutritional variables. Resting energy expenditure was significantly higher in patients in the EPA + GLA group, but their body mass index was also higher (p < .05). A significant difference was found in length of ventilation (p < .04) in favor of the EPA + GLA group. There was no between-group difference in survival. CONCLUSIONS: In patients with acute lung injury, a diet enriched with EPA + GLA may be beneficial for gas exchange, respiratory dynamics, and requirements for mechanical ventilation.

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Stehle et al. in a meta-analysis including only stable patients showed an advantage to administering GLN.
“Finally, Stehle et al. (235) in a meta-analysis including only stable patients showed an advantage to administering GLN.”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [235]

The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746 · see citing works
New methods for calculating metabolic rate with special reference to protein metabolism
Weir, J. B. D. V. (1949) · The Journal of Physiology · doi:10.1113/jphysiol.1949.sp004363 · Cited by 5,608 · see citing works
Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654 · see citing works
A biometric study of basal metabolism in man
Harris, J. A., & Benedict, F. G. (2014) · Medical Entomology and Zoology · Cited by 1,847 · see citing works
Using SPSS for Windows and Macintosh : Analyzing and Understanding Data
Green, S. B., & Salkind, N. J. (2004) · CERN Document Server (European Organization for Nuclear Research) · Cited by 1,335 · see citing works
Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome
Gadek, J. E., DeMichele, S. J., Karlstad, M. D., Pacht, E. R., Donahoe, M., Albertson, T. E., Van Hoozen, C., Wennberg, A. K., Nelson, J. L., & Noursalehi, M. (1999) · Critical Care Medicine · doi:10.1097/00003246-199908000-00001 · Cited by 757 · see citing works
Incidence and Mortality after Acute Respiratory Failure and Acute Respiratory Distress Syndrome in Sweden, Denmark, and Iceland
LUHR, O. R., Antonsen, K., Karlsson, M. K., Aardal, S., Thorsteinsson, A., FROSTELL, C. G., & Bonde, J. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.6.9808136 · Cited by 595 · see citing works
Incidence and Mortality of Acute Lung Injury and the Acute Respiratory Distress Syndrome in Three Australian States
Bersten, A. D., Edibam, C., Hunt, T. D., & Moran, J. L. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.4.2101124 · Cited by 456 · see citing works
Measurement of gas exchange in intensive care
Takala, J. A., Keinänen, O., Väisänen, P., & Kari, A. (1989) · Critical Care Medicine · doi:10.1097/00003246-198910000-00015 · Cited by 302 · see citing works
Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome
Pacht, E. R., DeMichele, S. J., Nelson, J. L., Hart, J., Wennberg, A. K., & Gadek, J. E. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000049952.96496.3e · Cited by 191 · see citing works
Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats
Mancuso, P., Whelan, J., DeMichele, S. J., Snider, C. C., Guszcza, J. A., & Karlstad, M. D. (1997) · Critical Care Medicine · doi:10.1097/00003246-199707000-00023 · Cited by 116 · see citing works
Intravenous fat emulsions and lung function
Skeie, B., ASKANAZ, J., Rothkopf, M. M., Rosenbaum, S. H., Kvetan, V., & Thomashow, B. M. (1988) · Critical Care Medicine · doi:10.1097/00003246-198802000-00018 · Cited by 115 · see citing works
Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats
Mancuso, P., Whelan, J., DeMichele, S. J., Snider, C. C., Guszcza, J. A., Claycombe, K., Smith, G. T., Gregory, T. J., & Karlstad, M. D. (1997) · Critical Care Medicine · doi:10.1097/00003246-199703000-00024 · Cited by 107 · see citing works
Effects of intravenous fat emulsions on lung function in patients with acute respiratory distress syndrome or sepsis
Suchner, U., Katz, D. P., Fürst, P., Beck, K., Felbinger, T. W., Senftleben, U., Thiel, M., Goetz, A. E., & Peter, K. (2001) · Critical Care Medicine · doi:10.1097/00003246-200108000-00012 · Cited by 98 · see citing works
Effect of short-term enteral feeding with eicosapentaenoic and γ-linolenic acids on alveolar macrophage eicosanoid synthesis and bactericidal function in rats
Palombo, J. D., DeMichele, S. J., Boyce, P. J., Lydon, E. E., Liu, J.-W., Huang, Y. S., Forse, R. A., Mizgerd, J. P., & Bistrian, B. R. (1999) · Critical Care Medicine · doi:10.1097/00003246-199909000-00032 · Cited by 71 · see citing works
Effect of enteral feeding with eicosapentaenoic acid, gamma‐linolenic acid, and antioxidants on antioxidant status in patients with acute respiratory distress syndrome
Nelson, J., DeMichele, S. J., Pacht, E. R., & Wennberg, A. (2003) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860710302700298 · Cited by 59 · see citing works
Fat Emulsions and Lung Function
Hageman, J. R., & Hunt, C. E. (1986) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00321-x · Cited by 54 · see citing works
New approaches to acute lung injury
Bigatello, L. M., & Zapol, W. M. (1996) · British Journal of Anaesthesia · doi:10.1093/bja/77.1.99 · Cited by 42 · see citing works
Impact of sepsis, lung injury, and the role of lipid infusion on circulating prostacyclin and thromboxane A2
Suchner, U., Katz, D., Fürst, P., Beck, K., Felbinger, T. W., Thiel, M., Senftleben, U., Goetz, A. E., & Peter, K. (2002) · Intensive Care Medicine · doi:10.1007/s00134-001-1192-3 · Cited by 42 · see citing works
Alveolar Epithelial Barrier: Acute Lung Injury
Matthay, M. A., Nuckton, T. J., & Brodie, D. (2000) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-662-13455-9_17 · Cited by 41 · see citing works

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Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694 · see citing works
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2769-8 · Cited by 7,282 · see citing works
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
McClave, S. A., Taylor, B. E., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115621863 · Cited by 3,982 · see citing works
ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904 · see citing works
Self-citation
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
McClave, S. A., Martindale, R. G., Vanek, V. W., McCarthy, M., Roberts, P., Taylor, B., Ochoa, J. B., Napolitano, L., Cresci, G., the A.S.P.E.N. Board of Directors, et al. (2009) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607109335234 · Cited by 1,873 · see citing works
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)
Alhazzani, W. A., Møller, M. H., Arabi, Y. M., Loeb, M. B., Gong, M. N., Fan, E., Oczkowski, S. J. W., Levy, M. M., Derde, L. P. G., Dzierba, A. L., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004363 · Cited by 1,567 · see citing works
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
Taylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476 · see citing works
Has Mortality from Acute Respiratory Distress Syndrome Decreased over Time?: A Systematic Review
Phua, J., Badia, J., Adhikari, N. K. J., Friedrich, J. O., Fowler, R., Singh, J. M., Scales, D. C., Stather, D. R., Li, A., Jones, A., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200805-722oc · Cited by 744 · see citing works
ESPEN Guidelines on Parenteral Nutrition: Surgery
Braga, M., Ljungqvist, O. H., Soeters, P. B., Fearon, K., Weimann, A., & Bozzetti, F. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.002 · Cited by 702 · see citing works
Nutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 587 · see citing works
Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury
Rice, T. W. (2011) · JAMA · doi:10.1001/jama.2011.1435 · Cited by 552 · see citing works
Mortality Rates for Patients With Acute Lung Injury/ARDS Have Decreased Over Time
Zambon, M., & Vincent, J. (2008) · CHEST Journal · doi:10.1378/chest.07-2134 · Cited by 536 · see citing works
Acute lung injury
Mowery, N. T., Terzian, W. T. H., & Nelson, A. C. (2020) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2020.100777 · Cited by 323 · see citing works
Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes
Sergeant, S., Rahbar, E., & Chilton, F. H. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.04.020 · Cited by 297 · see citing works
Immunonutrition in critically ill patients: a systematic review and analysis of the literature
Marik, P. E., & Zaloga, G. P. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1213-6 · Cited by 295 · see citing works
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Lipids
Lapillonne, A., Mis, N. F., Goulet, O., van den Akker, C. H. P., Wu, J., Koletzko, B., Braegger, C., Bronský, J., Cai, W., Campoy, C., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.06.946 · Cited by 280 · see citing works
The physiologic response and associated clinical benefits from provision of early enteral nutrition.
McClave, S. A., & Heyland, D. K. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533609335176 · Cited by 279 · see citing works
High-Protein Enteral Nutrition Enriched With Immune-Modulating Nutrients vs Standard High-Protein Enteral Nutrition and Nosocomial Infections in the ICU: A Randomized Clinical Trial
van Zanten, A. R. H., Sztark, F., Kaisers, U. X., Zielmann, S., Felbinger, T. W., Sablotzki, A. R., De Waele, J. J., Timsit, J.-F., Honing, M. L. H., Keh, D., et al. (2014) · JAMA · doi:10.1001/jama.2014.7698 · Cited by 279 · see citing works
Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition
Troesch, B., Eggersdorfer, M. L., Laviano, A., Rolland, Y., Smith, A. D., Warnke, I., Weimann, A., & Calder, P. C. (2020) · Nutrients · doi:10.3390/nu12092555 · Cited by 233 · see citing works
Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective
Singer, P., Shapiro, H., Theilla, M., Anbar, R., Singer, J., & Cohen, J. D. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1142-4 · Cited by 232 · see citing works
Self-citation
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Self-citation
The Anti-Inflammatory and Proresolving Mediator Resolvin E1 Protects Mice from Bacterial Pneumonia and Acute Lung Injury
Seki, H., Fukunaga, K., Arita, M., Arai, H., Nakanishi, H., Taguchi, R., Miyasho, T., Takamiya, R., Asano, K., Ishizaka, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901809 · Cited by 221 · see citing works
Severe Hypoxemic Respiratory Failure
Raoof, S., Goulet, K. E., Esan, A. O., HESS, D. R., & Sessler, C. N. (2010) · CHEST Journal · doi:10.1378/chest.09-2416 · Cited by 182 · see citing works
Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury
Eickmeier, O., Seki, H., Haworth, O., Hilberath, J. N., Gao, F., Uddin, M., Croze, R. H., Carlo, T., Pfeffer, M. A., & Levy, B. D. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.66 · Cited by 181 · see citing works
Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial
Barbosa, V. M., Miles, E. A., Calhau, C., Lafuente, E., & Calder, P. C. (2010) · Critical Care · doi:10.1186/cc8844 · Cited by 180 · see citing works
Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19
Rogero, M., Leão, M. D. C., Santana, T. M., Pimentel, M. V. D. M. B., Carlini, G. C., Silveira, T. F. D. D., Gonçalves, R. C., & Castro, I. A. (2020) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2020.07.005 · Cited by 293 · see citing works
A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury*
Stapleton, R. D., Martin, T. R., Weiss, N. S., Crowley, J. J., Gundel, S. J., Nathens, A. B., Akhtar, S. R., Ruzinski, J. T., Caldwell, E., Curtis, J. R., et al. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318218669d · Cited by 173 · see citing works
Effect of Dietary Fatty Acids on Inflammatory Gene Expression in Healthy Humans
Weaver, K. L., Ivester, P., Seeds, M. C., Case, L. D., Arm, J. P., & Chilton, F. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004861 · Cited by 165 · see citing works
Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group
Calder, P. C., Adolph, M., Deutz, N. E., Grau, T., Innes, J. K., Klek, S., Lev, S., Mayer, K., Michael-Titus, A. T., Pradelli, L., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.08.032 · Cited by 158 · see citing works
Self-citation
Immunonutrition in surgical and critically ill patients
Calder, P. C. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507832909 · Cited by 151 · see citing works
Clinical Nutrition in Critical Care Medicine – Guideline of the German Society for Nutritional Medicine (DGEM)
Elke, G., Hartl, W. H., Kreymann, K. G., Adolph, M., Felbinger, T. W., Graf, T., de Heer, G., Heller, A. R., Kampa, U., Mayer, K., et al. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.05.002 · Cited by 150 · see citing works
Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT Study
Pontes-Arruda, A., Martins, L. F., de Lima, S. M., Isola, A. M., Toledo, D., Rezende, E., Maia, M., Magnan, G. B., & the Investigating Nutritional Therapy with EPA, G. A. A. R. I. S. T. (. S. G. (2011) · Critical Care · doi:10.1186/cc10267 · Cited by 148 · see citing works
Severe Hypoxemic Respiratory Failure
Esan, A. O., HESS, D. R., Raoof, S., George, L., & Sessler, C. N. (2010) · CHEST Journal · doi:10.1378/chest.09-2415 · Cited by 143 · see citing works
Inflammation as the Key Interface of the Medical and Nutrition Universes: A Provocative Examination of the Future of Clinical Nutrition and Medicine
Jensen, G. L. (2006) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607106030005453 · Cited by 138 · see citing works
Prävention, Diagnose, Therapie und Nachsorge der Sepsis
Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Bardutzky, J., Dempfle, C. E., Forst, H., Gastmeier, P., Gerlach, H., Gründling, M., John, S., et al. (2010) · Der Anaesthesist · doi:10.1007/s00101-010-1719-5 · Cited by 135 · see citing works
Pharmaconutrition: a new emerging paradigm
Jones, N. E., & Heyland, D. K. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f4cdd8 · Cited by 134 · see citing works
Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses
Tonelli, A. R., Zein, J., Adams, J., & Ioannidis, J. P. A. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3272-1 · Cited by 133 · see citing works
[Prevention, diagnosis, treatment, and follow-up care of sepsis. First revision of the S2k Guidelines of the German Sepsis Society (DSG) and the German Interdisciplinary Association for Intensive and Emergency Care Medicine (DIVI)]
Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Bardutzky, J., Dempfle, C.-E., Forst, H., Gastmeier, P., Gerlach, H., Gründling, M., John, S., et al. (2010) · BORIS (University Library Bern) · doi:10.48350/654 · Cited by 129 · see citing works
Acute Respiratory Distress Syndrome: Etiology, Pathogenesis, and Summary on Management
Kaku, S., Nguyen, C. D., Htet, N. N., Tutera, D., Barr, J., Paintal, H. S., & Kuschner, W. G. (2019) · Journal of Intensive Care Medicine · doi:10.1177/0885066619855021 · Cited by 130 · see citing works
Fish oil supplementation in the parenteral nutrition of critically ill medical patients: a randomised controlled trial
Friesecke, S., Lotze, C., Köhler, J., Heinrich, A., Felix, S. B., & Abel, P. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1072-1 · Cited by 124 · see citing works
Effect of an enteral diet enriched with eicosapentaenoic acid, gamma-linolenic acid and anti-oxidants on the outcome of mechanically ventilated, critically ill, septic patients
Grau-Carmona, T., Morán-García, V., García-de-Lorenzo, A., Heras-de-la-Calle, G., Quesada-Bellver, B., López-Martínez, J., González-Fernández, C., Montejo-González, J. C., Blesa-Malpica, A., Albert-Bonamusa, I., et al. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.03.004 · Cited by 121 · see citing works
Immunonutrition and critical illness: An update
Mizock, B. A. (2010) · Nutrition · doi:10.1016/j.nut.2009.11.010 · Cited by 119 · see citing works
Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases
Giudetti, A. M., & Cagnazzo, R. (2012) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2012.09.006 · Cited by 109 · see citing works
Nutrients in prevention, treatment, and management of viral infections; special focus on Coronavirus
Bourbour, F., Dahka, S. M., Gholamalizadeh, M., Akbari, M. E., Shadnoush, M., Haghighi, M., Masoumi, H. T., Ashoori, N., & Doaei, S. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1791188 · Cited by 104 · see citing works
Clinical review: optimizing enteral nutrition for critically ill patients - a simple data-driven formula
Hegazi, R. A. F., & Wischmeyer, P. E. (2011) · Critical Care · doi:10.1186/cc10430 · Cited by 99 · see citing works
Brazilian recommendations of mechanical ventilation 2013. Part 2
Barbas, C. S. V., Ísola, A. M., Farias, A. M. D. C., Cavalcanti, A. B., Gama, A. M. C., Duarte, A. C. M., Vianna, A., Neto, A. S., Bravim, B. D. A., Pinheiro, B. V., et al. (2014) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20140034 · Cited by 97 · see citing works
Prolonged Weaning: S2k Guideline Published by the German Respiratory Society
Schönhofer, B., Geiseler, J. G., Dellweg, D., Fuchs, H. W., Moerer, O., Weber‐Carstens, S., Westhoff, M., & Windisch, W. (2020) · Respiration · doi:10.1159/000510085 · Cited by 94 · see citing works
Immunonutrition for acute respiratory distress syndrome (ARDS) in adults
Dushianthan, A., Cusack, R., Burgess, V. A., Grocott, M. P. W., & Calder, P. C. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012041.pub2 · Cited by 91 · see citing works
Omega-3 polyunsaturated fatty acids in critically ill patients with acute respiratory distress syndrome: A systematic review and meta-analysis
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Fish oil in critical illness
Mayer, K., & Seeger, W. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f4cdc6 · Cited by 89 · see citing works
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Shirai, K., Yoshida, S., Matsumaru, N., Toyoda, I., & Ogura, S. (2015) · Journal of Intensive Care · doi:10.1186/s40560-015-0087-2 · Cited by 47 · see citing works
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Mahmoud, A. A. A., Mahmoud, H. E., Mahran, M., & khaled, M. H. (2019) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2019.05.035 · Cited by 47 · see citing works
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Fish Oil in Critical Illness: Mechanisms and Clinical Applications
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Immune Enteral Nutrition Can Improve Outcomes in Medical-Surgical Patients with ARDS: A Prospective Randomized Controlled Trial
Elamin, E. M. (2012) · Journal of Nutritional Disorders & Therapy · doi:10.4172/2161-0509.1000109 · Cited by 43 · see citing works
Impact of a Nutritional Formula Enriched in Fish Oil and Micronutrients on Pressure Ulcers in Critical Care Patients
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Effects on hemodynamics and gas exchange of omega-3 fatty acid-enriched lipid emulsion in acute respiratory distress syndrome (ARDS): a prospective, randomized, double-blind, parallel group study
Sabater‐Riera, J., Masclans, J. R., Sacanell, J., Chacón, P. M., Sabin, P., & Planas, M. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-39 · Cited by 41 · see citing works

The Use of an Inflammation‐Modulating Diet in Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome: A Meta‐Analysis of Outcome Data
Pontes‐Arruda, A., DeMichele, S., Seth, A., & Singer, P. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108324203 · Cited by 230 · see citing works
Self-citation
Acute lung injury and acute respiratory distress syndrome
Singh, N. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61183-0 · Cited by 9 · see citing works
Effect of an enteral diet enriched with eicosapentaenoic acid, gamma-linolenic acid and anti-oxidants on the outcome of mechanically ventilated, critically ill, septic patients
Grau-Carmona, T., Morán-García, V., García-de-Lorenzo, A., Heras-de-la-Calle, G., Quesada-Bellver, B., López-Martínez, J., González-Fernández, C., Montejo-González, J. C., Blesa-Malpica, A., Albert-Bonamusa, I., et al. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.03.004 · Cited by 121 · see citing works
Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome
Gadek, J. E., DeMichele, S. J., Karlstad, M. D., Pacht, E. R., Donahoe, M., Albertson, T. E., Van Hoozen, C., Wennberg, A. K., Nelson, J. L., & Noursalehi, M. (1999) · Critical Care Medicine · doi:10.1097/00003246-199908000-00001 · Cited by 757 · see citing works
Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome
Pacht, E. R., DeMichele, S. J., Nelson, J. L., Hart, J., Wennberg, A. K., & Gadek, J. E. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000049952.96496.3e · Cited by 191 · see citing works

Authors: Singer, P., Theilla, M., Fisher, H., Gibstein, L., Grozovski, E., & Cohen, J.
Affiliations: Tel Aviv University (IL)
ORCID: Singer, Pierre
Cohen, Jonathan
Venue: Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-04
Volume: 34
Issue: 4
Pages: 1033-1038
ISSN: 0090-3493 (ISSN-L)
DOI: 10.1097/01.ccm.0000206111.23629.0a
OpenAlex: W2096340924
Cited by: 393
References: 20
Citations by year: 2026: 4 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 11 · 2017: 13 · 2016: 16 · 2015: 29 · 2014: 41 · 2013: 28 · 2012: 32
FWCI: 22.86
Type: journal article
Language: en
Open access: closed
Locations: Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords: acute lung injury, acute respiratory distress syndrome, enteral nutrition, eicosapentaenoic acid, gamma-linolenic acid, omega-3 fatty acids, antioxidants, mechanical ventilation, oxygenation, ventilator compliance, resting energy expenditure, mechanical ventilation duration, critically ill patients
MeSH terms: Adult, Enteral Nutrition, Female, Humans, Male, Middle Aged, Prospective Studies, Respiration, Artificial, Respiratory Distress Syndrome, Eicosapentaenoic Acid, Treatment Outcome, gamma-Linolenic Acid

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Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury*

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