Acute and Chronic Responses of Metabolic Myokine to Different Intensities of Exercise in Sedentary Young Women

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Progression Models in Resistance Training for Healthy Adults

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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

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Progression Models in Resistance Training for Healthy Adults

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Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake

Zhang, J. V., Ren, P.-G., Avsian-Kretchmer, O., Luo, C.-W., Rauch, R., Klein, C., & Hsueh, A. J. W. (2005) · Science · doi:10.1126/science.1117255 · Cited by 1,197 · see citing works

FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works

Both Comprehensive and Brief Self-Administered Diet History Questionnaires Satisfactorily Rank Nutrient Intakes in Japanese Adults

Kobayashi, S., Honda, S., Murakami, K., Sasaki, S., Okubo, H., Hirota, N., Notsu, A., Fukui, M., & Date, C. (2012) · Journal of Epidemiology · doi:10.2188/jea.je20110075 · Cited by 854 · see citing works

The effects of acute and chronic exercise on <scp>PGC</scp> ‐1α, irisin and browning of subcutaneous adipose tissue in humans

Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Jensen, J., & Drevon, C. A. (2014) · The FEBS Journal · doi:10.1111/febs.12619 · Cited by 563 · see citing works

The use of uniaxial accelerometry for the assessment of physical-activity-related energy expenditure: a validation study against whole-body indirect calorimetry

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Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index.

Stengel, A., Hofmann, T., Goebel-Stengel, M., Elbelt, U., Kobelt, P., & Klapp, B. (2013) · Peptides · doi:10.1016/j.peptides.2012.11.014 · Cited by 439 · see citing works

Is irisin a human exercise gene?

Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012) · Nature · doi:10.1038/nature11364 · Cited by 389 · see citing works

Evidence against a Beneficial Effect of Irisin in Humans

Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 318 · see citing works

Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men

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Are skeletal muscle <i>FNDC5</i> gene expression and irisin release regulated by exercise and related to health?

Pekkala, S., Wiklund, P. K., Hulmi, J. J., Ahtiainen, J. P., Horttanainen, M., Pöllänen, E., Mäkelä, K. A., Kainulainen, H., Häkkinen, K., Nyman, K., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.263707 · Cited by 292 · see citing works

Effects of Obestatin on Energy Balance and Growth Hormone Secretion in Rodents

Nogueiras, R., Pfluger, P. T., Tovar, S. A., Arnold, M., Mitchell, S. E., Morris, A., Pérez–Tilve, D., Vazquez, M. J., Wiedmer, P., Castañeda, T. R., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0915 · Cited by 265 · see citing works

Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

Daskalopoulou, S. S., Cooke, A. B., Sandoval, Y.-H. G., Mutter, A. F., Filippaios, A., Mesfum, E. T., & Mantzoros, C. S. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0204 · Cited by 216 · see citing works

Irisin in patients with nonalcoholic fatty liver disease

Polyzos, S. A., Kountouras, J., Anastasilakis, A. D., Geladari, E. V., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2013.09.013 · Cited by 215 · see citing works

Irisin and FNDC5 in retrospect

Erickson, H. (2013) · Adipocyte · doi:10.4161/adip.26082 · Cited by 211 · see citing works

Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue

Xu, X., Ying, Z., Cai, M., Xu, Z., Li, Y., Jiang, S. Y., Tzan, K., Wang, A., Parthasarathy, S., He, G., et al. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2010 · Cited by 200 · see citing works

High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption

Tsuchiya, Y., Ando, D., Goto, K., Kiuchi, M., Yamakita, M., & Koyama, K. (2014) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.233.135 · Cited by 176 · see citing works

Irisin, Light My Fire

Kelly, D. P. (2012) · Science · doi:10.1126/science.1221688 · Cited by 132 · see citing works

Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45min of a Turkish bath or running

Aydın, S., Aydın, S., Kuloğlu, T., Yılmaz, M., Kalayci, M., Sahin, İ., & Cicek, D. (2013) · Peptides · doi:10.1016/j.peptides.2013.09.011 · Cited by 118 · see citing works

Ghrelin and the Regulation of Food Intake and Energy Balance

Hosoda, H. (2002) · Molecular Interventions · doi:10.1124/mi.2.8.494 · Cited by 116 · see citing works

Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice

Green, B. D., Irwin, N., & Flatt, P. R. (2007) · Peptides · doi:10.1016/j.peptides.2007.02.003 · Cited by 103 · see citing works

Effects of Endurance and Resistance Training on Total Daily Energy Expenditure in Young Women: A Controlled Randomized Trial

Poehlman, É. T., DeNino, W. F., Beckett, T., Kinaman, K. A., Dionne, I. J., Dvorak, R. V., & Ades, P. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8282 · Cited by 98 · see citing works

The Effects of a 20-Week Exercise Training Program on Resting Metabolic Rate in Previously Sedentary, Moderately Obese Women

Byrne, H. K., & Wilmore, J. H. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.1.15 · Cited by 91 · see citing works

Minimal Resistance Training Improves Daily Energy Expenditure and Fat Oxidation

Kirk, E. P., Donnelly, J. E., SMITH, B. K., Honas, J. J., LeCheminant, J. D., Bailey, B. W., JACOBSEN, D. J., & Washburn, R. A. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318193c64e · Cited by 89 · see citing works

Biochemical Determination of Training Effects Using Insulin Clamp Technique

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Irisin Does Not Mediate Resistance Training–Induced Alterations in Resting Metabolic Rate

Scharhag‐Rosenberger, F., Meyer, T., Wegmann, M., Ruppenthal, S., Kaestner, L., Morsch, A., & Hecksteden, A. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000286 · Cited by 59 · see citing works

Regulation of energy homeostasis by peripheral signals

Woods, S. C., Benoit, S. C., Clegg, D. J., & Seeley, R. J. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.08.004 · Cited by 55 · see citing works

Irisin Levels are Not Affected by Physical Activity in Patients with Anorexia Nervosa

Hofmann, T., Elbelt, U., Ahnis, A., Kobelt, P., Rose, M., & Stengel, A. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00202 · Cited by 54 · see citing works

Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels

Tanisawa, K., Taniguchi, H., Sun, X., Ito, T., Cao, Z., Sakamoto, S., & Higuchi, M. (2014) · Metabolism · doi:10.1016/j.metabol.2014.01.005 · Cited by 51 · see citing works

Age-related differences in metabolic adaptations following resistance training in women

Dionne, I. J., Mélançon, M. O., Brochu, M., Ades, P. A., & Poelhman, E. T. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.006 · Cited by 43 · see citing works

Exercise training mode effects on myokine expression in healthy adults: A systematic review with meta-analysis

Bettariga, F., Taaffe, D. R., Galvão, D. A., Lopez, P., Bishop, C., Markarian, A. M., Natalucci, V., Kim, J.-S., & Newton, R. U. (2024) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2024.04.005 · Cited by 83 · see citing works

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

Dinas, P. C., Lahart, I. M., Timmons, J. A., Svensson, P.-A., Koutedakis, Y., Flouris, A. D., & Metsios, G. S. (2017) · F1000Research · doi:10.12688/f1000research.11107.2 · Cited by 51 · see citing works

Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging

Tero-Vescan, A., Degens, H., Matsakas, A., Ștefănescu, R., Ősz, B. E., & Slevin, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081222 · Cited by 44 · see citing works

Genetic Background (C57BL/6J Versus FVB/N) Strongly Influences the Severity of Diabetes and Insulin Resistance in ob/ob Mice

Haluzı́k, M., Colombo, C., Gavrilova, O., Chua, S. C., Wolf, N., Chen, M., STANNARD, B. S., Dietz, K. R., Roith, D. L., & Reitman, M. L. (2004) · Endocrinology · doi:10.1210/en.2004-0219 · Cited by 180 · see citing works

Peroxisome Proliferator-Activated Receptor-α Deficiency Does Not Alter Insulin Sensitivity in Mice Maintained on Regular or High-Fat Diet: Hyperinsulinemic-Euglycemic Clamp Studies

Haluzı́k, M., Gavrilova, O., & LeRoith, D. (2003) · Endocrinology · doi:10.1210/en.2003-1015 · Cited by 39 · see citing works

Chronic hyperinsulinemia contributes to insulin resistance under dietary restriction in association with altered lipid metabolism in Zucker diabetic fatty rats

Morita, I., Tanimoto, K., Akiyama, N., Naya, N., Fujieda, K., Iwasaki, T., & Yukioka, H. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00342.2016 · Cited by 19 · see citing works

Effect of short-and long-term caloric restriction on insulin resistance in male fisher-344 rats

Shu, C., Rusen, C., & Leakey, J. (1996) · Zhonghua neifenmi daixie zazhi

High-fat diet-induced obesity and insulin resistance in CYP4a14−/− mice is mediated by 20-HETE

Gilani, A., Pandey, V. G., Garcia, V. G., Agostinucci, K. J., Singh, S. P., Schragenheim, J., Bellner, L., Falck, J. R., Paudyal, M. P., Capdevila, J. H., et al. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00125.2018 · Cited by 51 · see citing works