The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Natural History of Drusenoid Pigment Epithelial Detachment in Age-Related Macular Degeneration: Age-Related Eye Disease Study Report No. 28
Open accessAbstract
Objective To describe the natural history of eyes with drusenoid pigment epithelial detachments (DPEDs) associated with age-related macular degeneration (AMD).Design Multicenter, clinic-based, prospective cohort study.Participants Among 4757 participants enrolled in the Age-Related Eye Disease Study (AREDS), 255 were identified as having DPED in at least 1 eye and having 5 or more years of follow-up after the initial detection of the DPED.Methods Baseline and annual fundus photographs were evaluated for the evolution of the fundus features and the development of advanced AMD in the forms of central geographic atrophy (CGA) or neovascular (NV) AMD. Kaplan-Meier analyses of progression to advanced AMD and of moderate vision loss (> or =15 letters compared with baseline) were performed.Main outcome measures Rate of progression to advanced AMD and change in visual acuity from baseline (in terms of mean letters lost and proportion losing > or =15 letters).Results A total of 311 eyes (from 255 participants) with DPED were followed for a median follow-up time of 8 years subsequent to the initial detection of a DPED. Of the 282 eyes that did not have advanced AMD at baseline, advanced AMD developed within 5 years in 119 eyes (42%) (19% progressing to CGA and 23% progressing to NV-AMD). In the remaining eyes that did not develop advanced AMD (n=163), progressive fundus changes, typified by the development of calcified drusen and pigmentary changes, were detected. Visual decline was prominent among study eyes, with approximately 40% of all eyes decreasing in visual acuity by > or =15 letters at 5 years follow-up. Mean visual acuity decreased from 76 letters ( approximately 20/30) at baseline to 61 letters ( approximately 20/60) at 5 years. Five-year decreases in mean visual acuity averaged 26 letters for eyes progressing to advanced AMD and 8 letters for non-progressing eyes.Conclusions The natural history of eyes containing DPED is characterized by a high rate of progression to both CGA and NV-AMD. Among eyes not progressing to advanced AMD, progressive development of pigmentary changes and calcified drusen were observed. Decline of visual acuity is a common outcome, with or without progression to advanced forms of AMD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“A previous report showed a relatively high rate of development of CNV (23%) in eyes with drusenoid PED with no advanced AMD at baseline (Cukras et al., 2010).”
From Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: Preliminary results in Asian patients (2015) · cites this paper as Cukras et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bird, A. C., Bressler, N. M., Bressler, S. B., Chisholm, I. H., Coscas, G., Davis, M. D., de Jong, P. T. V. M., Klaver, C. C. W., Klein, B. E. K., Klein, R., et al. (1995) · Survey of Ophthalmology · doi:10.1016/s0039-6257(05)80092-x · Cited by 1,926
Prevalence of age-related maculopathy
Klein, R., Klein, B. E. K., & Linton, K. L. P. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31871-8 · Cited by 1,845
A Simplified Severity Scale for Age-Related Macular Degeneration: AREDS Report No. 18
(2005) · Archives of Ophthalmology · doi:10.1001/archopht.123.11.1570 · Cited by 807
Evolution of geographic atrophy of the retinal pigment epithelium
Sarks, J. P., Sarks, S. H., & Killingsworth, M. C. (1988) · Eye · doi:10.1038/eye.1988.106 · Cited by 802
(2005) · Archives of Ophthalmology · doi:10.1001/archopht.123.11.1484 · Cited by 739
The Age-Related Eye Disease Study (AREDS)
The Age-Related Eye Disease Study Research Group (1999) · Controlled Clinical Trials · doi:10.1016/s0197-2456(99)00031-8 · Cited by 596
Drusen and Disciform Macular Detachment and Degeneration
Gass, J. D. M. (1973) · Archives of Ophthalmology · doi:10.1001/archopht.1973.01000050208006 · Cited by 593
(2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01218-1 · Cited by 556
Retinal Precursors and the Development of Geographic Atrophy in Age-Related Macular Degeneration
Klein, M. L., Ferris, F. L., Armstrong, J., Hwang, T. S., Chew, E. Y., Bressler, S. B., & Chandra, S. R. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2007.08.030 · Cited by 224
Bressler, N. M., Silva, J. C., Bressler, S. B., Fine, S. L., & GREEN, W. R. (2005) · Retina · doi:10.1097/00006982-200507001-00016 · Cited by 224
Cited by
Sorted by citations
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924
Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data
Spaide, R. F., Jaffe, G. J., Sarraf, D., Freund, K. B., Sadda, S. R., Staurenghi, G., Waheed, N. K., Chakravarthy, U., Rosenfeld, P. J., Holz, F. G., et al. (2020) · Ophthalmology · doi:10.1016/j.ophtha.2019.11.004 · Cited by 824
“52,53 Because measurements are typically performed digitally now, instead of using a standard circular measurement, 350 μm would be more convenient.”
Song, W. K., Park, K.-M., Kim, H.-J., Lee, J. H., Choi, J., Chong, S. Y., Shim, S. H., Del Priore, L. V., & Lanza, R. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.04.005 · Cited by 393
Risk factors for progression of age‐related macular degeneration
Heesterbeek, T. J., Lorés‐Motta, L., Hoyng, C. B., Lechanteur, Y. T. E., & den Hollander, A. I. (2020) · Ophthalmic and Physiological Optics · doi:10.1111/opo.12675 · Cited by 399
Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies
Curcio, C. A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24882 · Cited by 322
Metadata
- Authors
- Cukras, C., Agrón, E., Klein, M. L., Ferris, F. L., Chew, E. Y., Gensler, G., & Wong, W. T.
- Affiliations
- National Institutes of Health (US)
- Legacy Good Samaritan Medical Center (US)
- Emmes (United States) (US)
- Corresponding author
- Wong, Wai T.
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 117
- Issue
- 3
- Pages
- 489-499
- ISSN
- 0161-6420 (ISSN-L)
- PMC
- PMC2947750
- OpenAlex
- W2058344658
- Cited by
- 170
- References
- 17
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 12 · 2023: 4 · 2022: 13 · 2021: 14 · 2020: 18 · 2019: 9 · 2018: 9 · 2017: 14 · 2016: 15 · 2015: 3 · 2014: 7 · 2013: 12 · 2012: 9
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
- Keywords
- age-related macular degeneration, natural history (disease), neovascular AMD, visual acuity loss, disease progression, fundus changes, retinal pigment epithelium, choroidal neovascularization, macular atrophy
- MeSH terms
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Macular Degeneration, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Retinal Detachment, Visual Acuity, Retinal Drusen, Disease Progression, Retinal Pigment Epithelium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
