Cited by 177Antioxidant Activity and Oxidative StressCancer and biochemical researchRedox biology and oxidative stress

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Oxidative and antioxidative mechanisms in oral cancer and precancer: A review

Choudhari, Sheetal Korde, Chaudhary, Minal, Gadbail, Amol R., Sharma, Aparna, Tekade, Satyajit·2014·Oral Oncology

DOI 10.1016/j.oraloncology.2013.09.011

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Abstract

Development of cancer in humans is a multistep process. Complex series of cellular and molecular changes participating in cancer development are mediated by a diversity of endogenous and exogenous stimuli and important amongst this is generation of reactive oxygen species (ROS). Reactive radicals and non-radicals are collectively known as ROS. These can produce oxidative damage to the tissues and hence are known as oxidants in biological system. Many researchers have documented the role of ROS in both initiation and promotion of multistep carcinogenesis. To mitigate the harmful effects of free radicals, all aerobic cells are endowed with extensive antioxidant defence mechanisms. Lowered antioxidant capacity or the oxidant-antioxidant imbalance can lead to oxidative damage to cellular macromolecules leading to cancer. Oral cavity cancer is an important cancer globally and tobacco is the primary etiological factor in its development. Tobacco consumption exposes the oral epithelium to toxic oxygen and nitrogen free radicals that can affect host antioxidant defence mechanisms. Elevated levels of ROS and Reactive Nitrogen Species (RNS) and lowered antioxidants are found in oral precancer and cancer. Protection can be provided by various antioxidants against deleterious action of these free radicals. Treatment with antioxidants has the potential to prevent, inhibit and reverse the multiple steps involved in oral carcinogenesis. This review is an attempt to understand the interesting correlation between ROS and RNS mediated cell damage and enzymatic and non-enzymatic defence mechanisms involved in oral cancer development and its progression and the use of antioxidants in oral cancer prevention and treatment.

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Authors: Choudhari, S. K., Chaudhary, M., Gadbail, A. R., Sharma, A., & Tekade, S.
Corresponding author: Choudhari, Sheetal Korde
ORCID: Chaudhary, Minal
Gadbail, Amol R.
Sharma, Aparna
Tekade, Satyajit
Venue: Oral Oncology
Publisher: Elsevier BV
Published: 2014-01
Volume: 50
Issue: 1
Pages: 10-18
ISSN: 1368-8375 (ISSN-L)
DOI: 10.1016/j.oraloncology.2013.09.011
OpenAlex: W1969775662
Cited by: 177
References: 133
Citations by year: 2026: 4 · 2025: 12 · 2024: 15 · 2023: 16 · 2022: 20 · 2021: 16 · 2020: 18 · 2019: 12 · 2018: 20 · 2017: 7 · 2016: 14 · 2015: 14 · 2014: 9
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Locations: Oral Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oral cancer, oral precancer, reactive oxygen species, reactive nitrogen species, oxidative stress, antioxidant defense, free radicals, oxidative DNA damage, tobacco, oral carcinogenesis, antioxidant therapy, oral cancer prevention
MeSH terms: Antioxidants, Humans, Mouth Neoplasms, Precancerous Conditions, Reactive Oxygen Species, Oxidative Stress, Carcinogenesis

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Oxidative and antioxidative mechanisms in oral cancer and precancer: A review

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