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Cited by 137Antioxidant Activity and Oxidative StressNutritional Studies and DietPhytochemicals and Antioxidant Activities

Dietary antioxidants, circulating antioxidant concentrations, total antioxidant capacity, and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective observational studies

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Jayedi, Ahmad, Rashidy-Pour, Ali, Parohan, Mohammad, Zargar, Mahdieh Sadat, Shab-Bidar, Sakineh·2018·Advances in Nutrition
DOI 10.1093/advances/nmy040PMC PMC6247336
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Abstract

The associations of various dietary or circulating antioxidants with the risk of all-cause mortality in the general population have not been established yet. A systematic search was performed in PubMed and Scopus, from their inception up to October 2017. Prospective observational studies reporting risk estimates of all-cause mortality in relation to dietary intake and/or circulating concentrations of antioxidants were included. Random-effects meta-analyses were conducted. Forty-one prospective observational studies (total n = 507,251) involving 73,965 cases of all-cause mortality were included. The RRs of all-cause mortality for the highest compared with the lowest category of circulating antioxidant concentrations were as follows: total carotenes, 0.60 (95% CI: 0.46, 0.74); vitamin C, 0.61 (95% CI: 0.53, 0.69); selenium, 0.62 (95% CI: 0.45, 0.79); β-carotene, 0.63 (95% CI: 0.57, 0.70); α-carotene, 0.68 (95% CI: 0.58, 0.78); total carotenoids, 0.68 (95% CI: 0.56, 0.80); lycopene, 0.75 (95% CI: 0.54, 0.97); and α-tocopherol, 0.84 (95% CI: 0.77, 0.91). The RRs for dietary intakes were: total carotenoids, 0.76 (95% CI: 0.66, 0.85); total antioxidant capacity, 0.77 (95% CI: 0.73, 0.81); selenium, 0.79 (95% CI: 0.73, 0.85); α-carotene, 0.79 (95% CI: 0.63, 0.94); β-carotene, 0.82 (95% CI: 0.77, 0.86); vitamin C, 0.88 (95% CI: 0.83, 0.94); and total carotenes, 0.89 (95% CI: 0.81, 0.97). A nonsignificant inverse association was found for dietary zinc, zeaxanthin, lutein, and vitamin E. The nonlinear dose-response meta-analyses demonstrated a linear inverse association in the analyses of dietary β-carotene and total antioxidant capacity, as well as in the analyses of circulating α-carotene, β-carotene, selenium, vitamin C, and total carotenoids. The association appeared to be U-shaped in the analyses of serum lycopene and dietary vitamin C. The present study indicates that adherence to a diet with high antioxidant properties may reduce the risk of all-cause mortality. Our results confirm current recommendations that promote higher intake of antioxidant-rich foods such as fruit and vegetables.

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  • Higher dietary intake of vitamin E, as measured by serum alpha tocopherol levels, was associated with reduced mortality from several chronic conditions (cardiovascular diseases, stroke, cancer).

    “Higher dietary intake of vitamin E, as measured by serum alpha tocopherol levels, was associated with reduced mortality from several chronic conditions (cardiovascular diseases, stroke, cancer)”

    From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [366]

    The Vitamin E section reports an inverse association between circulating α-tocopherol and all-cause mortality, although it became nonsignificant when one heavily weighted study was excluded. It separately reports no significant association for dietary vitamin E intake and all-cause mortality, and does not establish reduced cardiovascular, stroke, or cancer mortality. (LLM, conf=0.88)

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Research works printed but not linked: 1

  1. Duarte TL, Lunec J. Review: when is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C. Free Radic Res 2005;39(7):671-86.

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Authors
Jayedi, A., Rashidy-Pour, A., Parohan, M., Zargar, M. S., & Shab-Bidar, S.
Affiliations
  • Tehran University of Medical Sciences (IR)
  • Semnan University of Medical Sciences (IR)
ORCID
Venue
Advances in Nutrition
Publisher
Elsevier BV
Published
2018-11
Volume
9
Issue
6
Pages
701-716
ISSN
  • 2156-5376 (ISSN-L)
  • 2161-8313
DOI
10.1093/advances/nmy040
PMC
PMC6247336
OpenAlex
W2891504254
Cited by
137
References
161
Citations by year
2026: 9 · 2025: 19 · 2024: 14 · 2023: 27 · 2022: 22 · 2021: 25 · 2020: 13 · 2019: 7 · 2018: 1
FWCI
1.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Advances in Nutrition (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
dietary antioxidants, total antioxidant capacity, all-cause mortality, carotenoids, vitamin C, selenium, lycopene, alpha-tocopherol, beta-carotene, alpha-carotene, dose-response relationship, mortality risk reduction, dietary intake, cardiovascular risk, neurodegenerative disease risk
MeSH terms
Lycopene, Antioxidants, Ascorbic Acid, Carotenoids, Cause of Death, Diet, Female, Humans, Male, Prospective Studies, Risk Factors, Selenium, Nonlinear Dynamics, alpha-Tocopherol, Observational Studies as Topic

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