The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mechanisms of heart failure in obesity
Open accessAbstract
Heart failure is a leading cause of morbidity and mortality and its prevalence continues to rise. Because obesity has been linked with heart failure, the increasing prevalence of obesity may presage further rise in heart failure in the future. Obesity-related factors are estimated to cause 11% of heart failure cases in men and 14% in women. Obesity may result in heart failure by inducing hemodynamic and myocardial changes that lead to cardiac dysfunction, or due to an increased predisposition to other heart failure risk factors. Direct cardiac lipotoxicity has been described where lipid accumulation in the heart results in cardiac dysfunction inexplicable of other heart failure risk factors. In this overview, we discussed various pathophysiological mechanisms that could lead to heart failure in obesity, including the molecular mechanisms underlying cardiac lipotoxicity. We defined the obesity paradox and enumerated various premises for the paradoxical associations observed in the relationship between obesity and heart failure.
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Obesity and Cardiovascular Disease
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Leptin, the obesity‐associated hormone, exhibits direct cardioprotective effects
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Obesity and left ventricular diastolic dysfunction
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Cited by
Piché, M.-E., Poirier, P., Lemieux, I., & Després, J.-P. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.06.004 · Cited by 558
Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications
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Ahmed, S. K., & Mohammed, R. A. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100375 · Cited by 432
Obesity and Cardiac Remodeling in Adults: Mechanisms and Clinical Implications
Alpert, M. A., Karthikeyan, K., Abdullah, O., & Ghadban, R. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.012 · Cited by 221
Adiposity, fat-free mass and incident heart failure in 500 000 individuals
Oguntade, A. S., Taylor, H., Lacey, B., & Lewington, S. (2024) · Open Heart · doi:10.1136/openhrt-2024-002711 · Cited by 31
“We did not find a significant association between VAT or any of the other fat measures and HFrEF despite significant associations of these measures with HFpEF.”
Metadata
- Authors
- Ebong, I. A., Goff, D. C., Rodriguez, C. J., Chen, H., & Bertoni, A. G.
- Venue
- Obesity Research & Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 8
- Issue
- 6
- Pages
- e540-e548
- ISSN
- 1871-403X (ISSN-L)
- OpenAlex
- W2081166327
- Cited by
- 251
- References
- 10
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- green
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