CoChat
Sign Up
Cited by 102Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

Obesity and left ventricular diastolic dysfunction

Berkalp, Berkten, Cesur, Vedia, Corapcioglu, Demet, Erol, Cetin, Baskal, Nilgun·1995·International Journal of Cardiology
DOI 10.1016/0167-5273(95)02431-u
Open this paper in CoChat — free account

Abstract

To assess the influence of obesity on left ventricular function, 20 obese women (mean body mass index (BMI) 33.8 +/- 3.1 kg/m2 and mean age 31.1 +/- 2.4 years) without evidence of heart disease were evaluated by echocardiography. Obese subjects had greater left ventricular mass index (103 +/- 22 g/m2, 76 +/- 18 g/m2; P < 0.0001) and augmented fractional shortening (39 +/- 2.6%, 36 +/- 0.1%; P < 0.0001) than normals. Isovolumic relaxation time was prolonged in the obese group (92 +/- 11 ms) as compared with the control group (76 +/- 11 ms; P < 0.0001). The ratio of peak early and atrial filling velocities was significantly lower (1.2 +/- 0.4, 1.9 +/- 0.6; P < 0.0001) and atrial contribution was higher (39 +/- 9, 25 +/- 5; P < 0.0001) in obese subjects than in normals. Shortened deceleration time was measured in obese subjects (142 +/- 30, 179 +/- 20 ms; P < 0.0001). In conclusion, obesity causes relaxation and early filling abnormalities and diastolic filling is compensated by augmented atrial contribution. Diastolic dysfunction is an early indicator of cardiac involvement in obesity.

Integrity signals

Registry

Crossref · 10.1016/0167-5273(95)02431-u

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Many published studies have concluded that obesity is independently associated with LV hypertrophy.

    “Many published studies have concluded that obesity is independently associated with LV hypertrophy (22, 28, 63, 72, 116, 235, 242, 266, 279, 284, 377).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [28]

  • LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity.

    “More recently, however, several studies have found that LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity (22, 28, 155, 191, 242, 274, 279, 375, 377).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [28]

  • Late diastolic (A-wave) velocities have been reported to be increased or unchanged in obese subjects.

    “Lastly, late diastolic (A-wave) velocities have been reported to be increased (28, 155, 242) or unchanged (266, 274, 279, 314).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [28]

  • Prolongation of the isovolumic relaxation time is probably the most consistent diastolic abnormality seen in obesity.

    “Prolongation of the isovolumic relaxation time is probably the most consistent diastolic abnormality seen in obesity (28, 242, 375).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [28]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Berkalp, B., Cesur, V., Corapcioglu, D., Erol, C., & Baskal, N.
Affiliations
Ankara University (TR)
Corresponding author
Berkalp, Berkten
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
1995-11
Volume
52
Issue
1
Pages
23-26
ISSN
0167-5273 (ISSN-L)
DOI
10.1016/0167-5273(95)02431-u
OpenAlex
W2128710157
Cited by
102
References
13
Citations by year
2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 4 · 2014: 5 · 2013: 7 · 2012: 6
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
obesity, left ventricular diastolic dysfunction, left ventricular mass, isovolumic relaxation time, diastolic filling, early diastolic filling velocity, women
MeSH terms
Adult, Diastole, Female, Hemodynamics, Humans, Middle Aged, Obesity, Systole, Body Mass Index, Case-Control Studies, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Echocardiography, Doppler, Pulsed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review