Effect of Obesity and Overweight on Left Ventricular Diastolic Function

Russo, Cesare; Jin, Zhezhen; Homma, Shunichi; Rundek, Tatjana; Elkind, Mitchell S.V.; Sacco, Ralph L.; Di Tullio, Marco R.

doi:10.1016/j.jacc.2010.10.042

Cited by 361Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

Effect of Obesity and Overweight on Left Ventricular Diastolic Function

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Russo, Cesare, Jin, Zhezhen, Homma, Shunichi, Rundek, Tatjana, Elkind, Mitchell S.V., Sacco, Ralph L., Di Tullio, Marco R.·2011·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2010.10.042PMC PMC3077126

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Abstract

Objectives The purpose of this study was to assess the independent effect of increased body size on left ventricular (LV) diastolic function.Background Obese and overweight persons are at increased risk of heart failure. Left ventricular diastolic dysfunction is an asymptomatic condition associated with future heart failure. It is unclear whether obesity and overweight are independently associated with LV diastolic dysfunction.Methods The LV diastolic function was evaluated in 950 participants from the CABL (Cardiovascular Abnormalities and Brain Lesions) study by traditional and tissue Doppler imaging. Peak early transmitral diastolic flow velocity (E), late transmitral diastolic flow velocity (A), and early diastolic mitral annulus velocity (E') were measured, and E/A and E/E' were calculated. The study sample was divided into 3 groups: normal weight (body mass index [BMI] <25.0 kg/m(2)), overweight (BMI 25.0 to 29.9 kg/m(2)), and obese (BMI ≥30 kg/m(2)).Results In multivariate analyses, BMI was independently associated with higher E, A, and E/E', an indicator of LV filling pressure (all p ≤ 0.01). Overweight and obese had lower E' (both p < 0.01) and higher E/E' (both p < 0.01) than normal weight participants. The E/A was lower in obese subjects than in normal weight subjects (p < 0.01). The risk of diastolic dysfunction was significantly higher in overweight subjects (adjusted odds ratio: 1.52, 95% confidence interval: 1.04 to 2.22) and obese subjects (adjusted odds ratio: 1.60, 95% confidence interval: 1.06 to 2.41) compared to normal weight subjects.Conclusions Increased BMI was associated with worse LV diastolic function independent of LV mass and associated risk factors. The increased risk of LV diastolic dysfunction in both overweight and obese persons may partially account for the increased risk of heart failure associated with both conditions.

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Obese patients may have more LV diastolic dysfunction, increased sympathetic activity and inflammation, and increased fatty infiltration of the atria.
“Obese patients may have more LV diastolic dysfunction, increased sympathetic activity and inflammation, and increased fatty infiltration of the atria.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [294]

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Rider, O. J., Lewis, A., & Neubauer, S. (2014) · Obesity Facts · doi:10.1159/000368429 · Cited by 31 · see citing works
Effect of Overweight and Obesity (Defined by Asian-Specific Cutoff Criteria) on Left Ventricular Diastolic Function and Structure in a General Korean Population
Park, S. K., Ryoo, J., Oh, C., Choi, J., Kang, J., Lee, J.-H., Chung, J. Y., & Jung, J. Y. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0625 · Cited by 30 · see citing works

Obesity as an independent risk for left ventricular diastolic dysfunction in 692 Japanese patients
Dote, K., Miyasaka, Y., Tsujimoto, S., Motohiro, M., Maeba, H., Suwa, Y., & Iwasaka, T. (2012) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2012.01.001 · Cited by 9 · see citing works
Impact of Body Mass Index on Left Ventricular Diastolic Dysfunction
Çil, H., Bulur, S., Türker, Y., Kaya, A., Alemdar, R., Karabacak, A., Aslantaş, Y., Ekinözü, İ., Albayrak, S., Özhan, H., et al. (2012) · Echocardiography · doi:10.1111/j.1540-8175.2012.01688.x · Cited by 46 · see citing works
A Study of the Impact of Body Mass Index on Diastolic Function in Patients with Normal Left Ventricular Ejection Fraction
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Relationship of Left Ventricular Diastolic Function to Obesity and Overweight in a Japanese Population With Preserved Left Ventricular Ejection Fraction
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Self-citation
Effect of Body Mass Index on Left Ventricular Diastolic Function
Al-Meshhadani, M. H., Rgeeb, A. N., & Ali, A. E. (2018) · kufa journal for nursing sciences · doi:10.36321/kjns.vi20172.2278

Authors: Russo, C., Jin, Z., Homma, S., Rundek, T., Elkind, M. S. V., Sacco, R. L., & Di Tullio, M. R.
Affiliations: Columbia University (US)
University of Miami (US)
ORCID: Russo, Cesare
Jin, Zhezhen
Rundek, Tatjana
Elkind, Mitchell S.V.
Sacco, Ralph L.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2011-03
Volume: 57
Issue: 12
Pages: 1368-1374
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2010.10.042
PMC: PMC3077126
OpenAlex: W1562293187
Cited by: 361
References: 46
Citations by year: 2026: 14 · 2025: 26 · 2024: 25 · 2023: 14 · 2022: 25 · 2021: 28 · 2020: 23 · 2019: 21 · 2018: 25 · 2017: 30 · 2016: 29 · 2015: 28 · 2014: 24 · 2013: 22 · 2012: 18
FWCI: 16.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 868 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01 NS36286, R37 NS29993)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obesity, overweight, left ventricular diastolic dysfunction, body mass index, heart failure risk, tissue Doppler imaging, mitral annular velocity, left ventricular filling pressure, E/e' ratio, E/A ratio
MeSH terms: Aged, Aged, 80 and over, Diastole, Female, Heart Failure, Humans, Male, Middle Aged, Obesity, Body Mass Index, Multivariate Analysis, Ventricular Dysfunction, Left, Overweight

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Effect of Obesity and Overweight on Left Ventricular Diastolic Function

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