Cited by 220Pain Mechanisms and TreatmentsPain Management and Placebo EffectMusculoskeletal pain and rehabilitation

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables

Edwards, Robert R, Ness, Timothy J, Weigent, Douglas A, Fillingim, Roger B·2003·Pain

DOI 10.1016/j.pain.2003.09.005

Open this paper in CoChat — free account

Abstract

Laboratory pain research has been criticized as being irrelevant to the clinical experience of pain. Previous findings have been inconsistent with some studies suggesting that experimental pain responses may be related to the reported presence or severity of chronic pain, while others report no such associations. However, few of these studies assess a variety of laboratory pain responses, and none has assessed relationships between clinical pain and diffuse noxious inhibitory controls (DNIC) in healthy subjects. We administered questionnaire measures of pain, quality of life, and psychological variables to a sample of healthy adults participating in a laboratory study of age differences in pain responses. DNIC was not related to other laboratory pain responses, psychological variables, or physiological variables measured in the present study. Regression models predicting health-related quality of life (e.g. pain, physical functioning) revealed that age, sex, and DNIC responses explained between 10 and 25% of the variance in these dependent measures. Of the laboratory pain variables, only DNIC was the sole consistent predictor of clinical pain and physical health, with greater DNIC responses related to less pain, better physical functioning, and better self-rated health. In addition, age differences in DNIC appeared to partially mediate age differences in physical functioning. These findings highlight the potential clinical relevance of experimental pain procedures and suggest that DNIC may be the laboratory pain response most closely associated with clinical pain and health-related variables.

Integrity signals

Registry

Crossref · 10.1016/j.pain.2003.09.005

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
(1992) · PubMed · Cited by 33,716
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
The Stress Process
Pearlin, L. I., Menaghan, E. G., Lieberman, M. A., & Mullan, J. T. (1981) · Journal of Health and Social Behavior · doi:10.2307/2136676 · Cited by 6,289 · cited 2×
“The seven-item SOM scale (Pearlin et al., 1981) was used to assess respondents’ general sense of life control and mastery.”
Method
Development of the multidimensional health locus of control (MHLC) scales
Wallston, K. A., Strudler Wallston, B., & DeVellis, R. (1978) · Health Education Monographs · doi:10.1177/109019817800600107 · Cited by 3,373 · cited 2×
“Multidimensional health locus of control (MHLC) The MHLC (Wallston et al., 1978) is an 18-item instrument assessing three dimensions of health-specific locus of control.”
Method
Textbook of pain
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Salivary cortisol in psychoneuroendocrine research: recent developments and applications
Kirschbaum, C., & Hellhammer, D. H. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90013-2 · Cited by 2,107
Salivary Cortisol in Psychobiological Research: An Overview
Kirschbaum, C., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000118611 · Cited by 1,532
Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications?
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · cited 1×
“Relative to controls, patients with fibromyalgia (FM; Hurtig et al., 2001), whiplash (Kasch et al., 2001), headache (Bendtsen, 2000), temporomandibular disorder (TMD; Svensson et al., 2001), and irritable bowel syndrome (Whitehead et al., 2002) show enhanced pain sensitivity.”
Background
Prevalence of chronic benign pain disorder among adults: a review of the literature
Verhaak, P. F. M., Kerssens, J. J., Dekker, J., Sorbi, M. J., & Bensing, J. M. (1998) · Pain · doi:10.1016/s0304-3959(98)00117-1 · Cited by 743
Central Sensitization in Tension-Type Headache—Possible Pathophysiological Mechanisms
Bendtsen, L. (2000) · Cephalalgia · doi:10.1046/j.1468-2982.2000.00070.x · Cited by 593
Possible Deficiencies of Pain Modulation in Fibromyalgia
Lautenbacher, S., & Rollman, G. B. (1997) · Clinical Journal of Pain · doi:10.1097/00002508-199709000-00003 · Cited by 546
Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects
Kosek, E., & Hansson, P. T. (1997) · Pain · doi:10.1016/s0304-3959(96)03295-2 · Cited by 539
Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief
Kosek, E., & Ordeberg, G. (2000) · Pain · doi:10.1016/s0304-3959(00)00310-9 · Cited by 476
The epidemiology of pain in elderly people
Helme, R. D., & Gibson, S. J. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70078-1 · Cited by 451
Age-related differences in pain perception and report
Gibson, S. J., & Helme, R. D. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70079-3 · Cited by 432
Social Psychology of Health and Illness
Sanders, G. S., & Suls, J. M. (2013) · Psychology Press eBooks · doi:10.4324/9780203762967 · Cited by 386
Motivation, emotion, and personality
SPENCE, J. T., & Izard, C. E. (1985) · Elsevier eBooks · Cited by 373
Ethnic Differences in Pain Tolerance: Clinical Implications in a Chronic Pain Population
Edwards, R. R., Doleys, D. M., Fillingim, R. B., & Lowery, D. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200103000-00018 · Cited by 358
Self-citation
Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults
Edwards, R. R., Fillingim, R. B., & Ness, T. J. (2002) · Pain · doi:10.1016/s0304-3959(02)00324-x · Cited by 356
Self-citation
Chronic pain in elderly people
Gagliese, L., & Melzack, R. (1997) · Pain · doi:10.1016/s0304-3959(96)03266-6 · Cited by 334
The SF-36 Health Survey
Ware, J. E., Kosinski, M. R., & Keller, S. (1990) · Cited by 312
Sex differences in temporal summation but not sensory-discriminative processing of thermal pain
Fillingim, R. B., Maixner, W., Kincaid, S., & Silva, S. (1998) · Pain · doi:10.1016/s0304-3959(97)00214-5 · Cited by 289
Self-citation
Multi-method assessment of experimental and clinical pain in patients with fibromyalgia
Lautenbacher, S., Rollman, G. B., & McCain, G. A. (1994) · Pain · doi:10.1016/0304-3959(94)90046-9 · Cited by 270
Optimism, self-mastery, and symptoms of depression in women professionals.
Marshall, G. N., & Lang, E. L. (1990) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.59.1.132 · Cited by 259
Optimism, self-mastery, and symptoms of depression in women professionals.
Marshall, G. N., & Lang, E. L. (1990) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.59.1.132 · Cited by 259
Age-related differences in the endogenous analgesic response to repeated cold water immersion in human volunteers
Washington, L. L., Gibson, S. J., & Helme, R. D. (2000) · Pain · doi:10.1016/s0304-3959(00)00352-3 · Cited by 223
The relationship of sex and clinical pain to experimental pain responses
Fillingim, R. B., Edwards, R. R., & Powell, T. (1999) · Pain · doi:10.1016/s0304-3959(99)00128-1 · Cited by 223
Self-citation
Ethnic Differences in Thermal Pain Responses
Edwards, R. R., & Fillingim, R. B. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199905000-00014 · Cited by 221
Self-citation
Response properties of nociceptive and non-nociceptive neurons in the rat's trigeminal subnucleus caudalis (medullary dorsal horn) related to cutaneous and deep craniofacial afferent stimulation and modulation by diffuse noxious inhibitory controls
Hu, J. W. (1990) · Pain · doi:10.1016/0304-3959(90)90010-b · Cited by 202
Pain Sensitivity as a Correlate of Clinical Status in Individuals With Chronic Low Back Pain
Clauw, D. J., Williams, D. A., Lauerman, W. C., Dahlman, M., Aslami, A., NACHEMSON, A. L., Kobrine, A. I., & Wiesel, S. W. (1999) · Spine · doi:10.1097/00007632-199910010-00013 · Cited by 191
Effects of age on temporal summation and habituation of thermal pain: Clinical relevance in healthy older and younger adults
Edwards, R. R., & Fillingim, R. B. (2001) · Journal of Pain · doi:10.1054/jpai.2001.25525 · Cited by 189
Self-citation
Diffuse noxious inhibitory controls in man: Involvement of an opioidergic link
Willer, J. C., Bars, D. L., & de Broucker, T. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90293-f · Cited by 186
Quantitative Sensory Testing in Fibromyalgia Patients and in Healthy Subjects: Identification of Subgroups
Hurtig, I., Raak, R., Kendall, S., Gerdle, B., & Wahren, L. (2001) · The Clinical Journal of Pain · doi:10.1097/00002508-200112000-00005 · Cited by 177
Analysis of stimulus-evoked pain in patients with myofascial temporomandibular pain disorders
Svensson, P. J., List, T., & Hector, G. (2001) · Pain · doi:10.1016/s0304-3959(01)00284-6 · Cited by 157
Adrenocortical and hemodynamic predictors of pain perception in men and women
Al’Absi, M., Petersen, K. L., & Wittmers, L. E. (2002) · Pain · doi:10.1016/s0304-3959(01)00447-x · Cited by 154
Age-Associated Differences in Responses to Noxious Stimuli
Edwards, R. R., & Fillingim, R. B. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.3.m180 · Cited by 144
Self-citation
Pain in older persons
Gibson, S. J., Katz, B., Corran, T. M., Farrell, M. J., & Helme, R. D. (1994) · Disability and Rehabilitation · doi:10.3109/09638289409166289 · Cited by 143
Effects of heterotopic conditioning stimuli on first and second pain: A psychophysical evaluation in humans
Price, D. D., & McHaffie, J. G. (1988) · Pain · doi:10.1016/0304-3959(88)90119-4 · Cited by 125
Endogenous mechanisms of sensory modulation
Dubner, R. A., & Ren, K. (1999) · Pain · doi:10.1016/s0304-3959(99)00137-2 · Cited by 118
Pain Sensitivity in Patients with Temporomandibular Disorders: Relationship to Clinical and Psychosocial Factors
Fillingim, R. B., Maixner, W. D., Kincaid, S., Sigurðsson, Á., & Harris, M. B. (1996) · Clinical Journal of Pain · doi:10.1097/00002508-199612000-00005 · Cited by 106
Self-citation
Associations Between Pain, Grip Strength, and Manual Tests in the Treatment Evaluation of Chronic Tennis Elbow
Pienimäki, T., Tarvainen, T. K., Siira, P. T., Malmivaara, A. V., & Vanharanta, H. V. (2002) · Clinical Journal of Pain · doi:10.1097/00002508-200205000-00005 · Cited by 93
Pain Thresholds and Tenderness in Neck and Head Following Acute Whiplash Injury: A Prospective Study
Kasch, H., Stengaard‐Pedersen, K., Arendt‐Nielsen, L., & Jensen, T. S. (2001) · Cephalalgia · doi:10.1046/j.1468-2982.2001.00179.x · Cited by 92
Measuring Ankle Systolic Blood Pressure: Validation of the Dinamap 1846 SX
Mundt, K. A., Chambless, L. E., Burnham, C. B., & HEISS, G. M. (1992) · Angiology · doi:10.1177/000331979204300703 · Cited by 77
The encoding of thermal stimuli by diffuse noxious inhibitory controls (DNIC)
Bars, D. L., Chitour, D., & Clot, A. M. (1981) · Brain Research · doi:10.1016/0006-8993(81)90422-4 · Cited by 77
Effects of experimental and clinical noxious counterirritants on pain perception
Sigurðsson, Á., & Maixner, W. D. (1994) · Pain · doi:10.1016/0304-3959(94)90002-7 · Cited by 72
Reactivity and response to pain
Dubreuil, D. L., & Kohn, P. M. (1986) · Personality and Individual Differences · doi:10.1016/0191-8869(86)90093-0 · Cited by 66
Handbook of Pain and Aging
Mostofsky, D. I., & Lomranz, J. (1997) · Springer eBooks · doi:10.1007/978-1-4899-0283-2 · Cited by 58
Neuroendocrinology of Aging in the Male and Female
Urban, R. J. (1992) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30195-6 · Cited by 48
The ability of inhibitory controls to ‘switch-off’ activity in dorsal horn convergent neurones in the rat
Cadden, S. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90938-j · Cited by 33
A Population Survey of Cardiovascular Disease in Elderly People: Design, Methods and Prevalence Results
Dewhurst, G., Wood, D. A., Walker, F., Lampe, F. C., JEFFREYS, M., Cooper, M. E., & Williams, J. D. (1991) · Age and Ageing · doi:10.1093/ageing/20.5.353 · Cited by 31
Experimental pain sensitivity and reports of negative thoughts in adults with sickle cell disease
Gil, K. M., Phillips, G., Webster, D. A., Martin, N. J., Abrams, M. A., Grant, M. M., Clark, W. C., & Janal, M. N. (1995) · Behavior Therapy · doi:10.1016/s0005-7894(05)80106-6 · Cited by 29
Low hot pain threshold predicts shorter time to exercise-induced angina: results from the psychophysiological investigations of myocardial ischemia (PIMI) study
Sheps, D. S., McMahon, R. P., Light, K. C., Maixner, W. D., Pepine, C. J., Cohen, J. D., Goldberg, A. D., Bonsall, R. W., Carney, R. M., Stone, P. H., et al. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00099-6 · Cited by 26
Pain and Psychological Function in Late Life
Parmelee, P. A. (1997) · Springer eBooks · doi:10.1007/978-1-4899-0283-2_10 · Cited by 22

Flagged first, then by citations

1 of the 55 references couldn’t be matched to a known paper.

Sorted by citations

Sex, gender, and pain: a review of recent clinical and experimental findings
Fillingim, R. B., King, C. D., Ribeiro-Dasilva, M. C., Rahim-Williams, B., & Riley, J. L. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2008.12.001 · Cited by 2,766
Self-citation
Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk
Yarnitsky, D., Crispel, Y., Eisenberg, E., Granovsky, Y., Ben-Nun, A., Sprecher, E., Best, L.-A., & Granot, M. (2008) · Pain · doi:10.1016/j.pain.2007.10.033 · Cited by 750
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719
Self-citation
Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy
Yarnitsky, D., Granot, M., Nahman‐Averbuch, H., Khamaisi, M., & Granovsky, Y. (2012) · Pain · doi:10.1016/j.pain.2012.02.021 · Cited by 561
Experimental and Clinical Applications of Quantitative Sensory Testing Applied to Skin, Muscles and Viscera
Arendt‐Nielsen, L., & Yarnitsky, D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.002 · Cited by 548

See all 220

Authors: Edwards, R. R., Ness, T. J., Weigent, D. A., & Fillingim, R. B.
Affiliations: Johns Hopkins University (US)
University of Alabama at Birmingham (US)
University of Florida (US)
Corresponding author: Edwards, Robert R
ORCID: Edwards, Robert R
Ness, Timothy J
Fillingim, Roger B
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-12
Volume: 106
Issue: 3
Pages: 427-437
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2003.09.005
OpenAlex: W2080207646
Cited by: 220
References: 55
Citations by year: 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 19 · 2014: 11 · 2013: 17 · 2012: 16
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: University of Alabama at Birmingham
National Institutes of Health
National Institute on Drug Abuse (DA 06060)
National Institute of Dental and Craniofacial Research (DE 12261, R29DE012261)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords: diffuse noxious inhibitory control, experimental pain, chronic pain, health-related quality of life, physical function, self-rated health, age differences, sex differences, individual differences
MeSH terms: Adult, Age Factors, Aged, Analysis of Variance, Female, Follow-Up Studies, Humans, Individuality, Inhibition, Psychological, Male, Middle Aged, Pain Measurement, Quality of Life, Regression Analysis, Chi-Square Distribution, Pain Threshold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks