The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables
Abstract
Laboratory pain research has been criticized as being irrelevant to the clinical experience of pain. Previous findings have been inconsistent with some studies suggesting that experimental pain responses may be related to the reported presence or severity of chronic pain, while others report no such associations. However, few of these studies assess a variety of laboratory pain responses, and none has assessed relationships between clinical pain and diffuse noxious inhibitory controls (DNIC) in healthy subjects. We administered questionnaire measures of pain, quality of life, and psychological variables to a sample of healthy adults participating in a laboratory study of age differences in pain responses. DNIC was not related to other laboratory pain responses, psychological variables, or physiological variables measured in the present study. Regression models predicting health-related quality of life (e.g. pain, physical functioning) revealed that age, sex, and DNIC responses explained between 10 and 25% of the variance in these dependent measures. Of the laboratory pain variables, only DNIC was the sole consistent predictor of clinical pain and physical health, with greater DNIC responses related to less pain, better physical functioning, and better self-rated health. In addition, age differences in DNIC appeared to partially mediate age differences in physical functioning. These findings highlight the potential clinical relevance of experimental pain procedures and suggest that DNIC may be the laboratory pain response most closely associated with clinical pain and health-related variables.
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“social support is found to be associated with improved physical functioning for individuals with pain conditions 33, 87–89.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [87]
In the citing paper
“It is clear that the interactions between patients with chronic pain and their significant others can either facilitate or impair adjustment to chronic pain 87, 120–122.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [87]
Citations
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Sex, gender, and pain: a review of recent clinical and experimental findings
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Self-citationPrediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk
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Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719
Self-citationConditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy
Yarnitsky, D., Granot, M., Nahman‐Averbuch, H., Khamaisi, M., & Granovsky, Y. (2012) · Pain · doi:10.1016/j.pain.2012.02.021 · Cited by 561
Arendt‐Nielsen, L., & Yarnitsky, D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.002 · Cited by 548
Metadata
- Authors
- Edwards, R. R., Ness, T. J., Weigent, D. A., & Fillingim, R. B.
- Affiliations
- Johns Hopkins University (US)
- University of Alabama at Birmingham (US)
- University of Florida (US)
- Corresponding author
- Edwards, Robert R
- Venue
- Pain
- Published
- 2003-12
- Volume
- 106
- Issue
- 3
- Pages
- 427-437
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2080207646
- Cited by
- 220
- References
- 55
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 19 · 2014: 11 · 2013: 17 · 2012: 16
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Alabama at Birmingham
- National Institutes of Health
- National Institute on Drug Abuse (DA 06060)
- National Institute of Dental and Craniofacial Research (DE 12261, R29DE012261)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- diffuse noxious inhibitory control, experimental pain, chronic pain, health-related quality of life, physical function, self-rated health, age differences, sex differences, individual differences
- MeSH terms
- Adult, Age Factors, Aged, Analysis of Variance, Female, Follow-Up Studies, Humans, Individuality, Inhibition, Psychological, Male, Middle Aged, Pain Measurement, Quality of Life, Regression Analysis, Chi-Square Distribution, Pain Threshold
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