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Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables

Edwards, Robert R, Ness, Timothy J, Weigent, Douglas A, Fillingim, Roger B·2003·Pain

DOI 10.1016/j.pain.2003.09.005

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Abstract

Laboratory pain research has been criticized as being irrelevant to the clinical experience of pain. Previous findings have been inconsistent with some studies suggesting that experimental pain responses may be related to the reported presence or severity of chronic pain, while others report no such associations. However, few of these studies assess a variety of laboratory pain responses, and none has assessed relationships between clinical pain and diffuse noxious inhibitory controls (DNIC) in healthy subjects. We administered questionnaire measures of pain, quality of life, and psychological variables to a sample of healthy adults participating in a laboratory study of age differences in pain responses. DNIC was not related to other laboratory pain responses, psychological variables, or physiological variables measured in the present study. Regression models predicting health-related quality of life (e.g. pain, physical functioning) revealed that age, sex, and DNIC responses explained between 10 and 25% of the variance in these dependent measures. Of the laboratory pain variables, only DNIC was the sole consistent predictor of clinical pain and physical health, with greater DNIC responses related to less pain, better physical functioning, and better self-rated health. In addition, age differences in DNIC appeared to partially mediate age differences in physical functioning. These findings highlight the potential clinical relevance of experimental pain procedures and suggest that DNIC may be the laboratory pain response most closely associated with clinical pain and health-related variables.

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Authors: Edwards, R. R., Ness, T. J., Weigent, D. A., & Fillingim, R. B.
Affiliations: Johns Hopkins University (US)
University of Alabama at Birmingham (US)
University of Florida (US)
Corresponding author: Edwards, Robert R
ORCID: Edwards, Robert R
Ness, Timothy J
Fillingim, Roger B
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-12
Volume: 106
Issue: 3
Pages: 427-437
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2003.09.005
OpenAlex: W2080207646
Cited by: 220
References: 55
Citations by year: 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 19 · 2014: 11 · 2013: 17 · 2012: 16
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: University of Alabama at Birmingham
National Institutes of Health
National Institute on Drug Abuse (DA 06060)
National Institute of Dental and Craniofacial Research (DE 12261, R29DE012261)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords: diffuse noxious inhibitory control, experimental pain, chronic pain, health-related quality of life, physical function, self-rated health, age differences, sex differences, individual differences
MeSH terms: Adult, Age Factors, Aged, Analysis of Variance, Female, Follow-Up Studies, Humans, Individuality, Inhibition, Psychological, Male, Middle Aged, Pain Measurement, Quality of Life, Regression Analysis, Chi-Square Distribution, Pain Threshold

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Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables

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