The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area
Abstract
The novel neuropeptides orexin A and B are selectively synthesised in the lateral and posterior hypothalamus and are involved in hypothalamic regulation of autonomic and neuroendocrine functions. Recent findings point also to a role in nociception. As the posterior hypothalamus is involved in the central modulation of nociception we studied the effects of hypocretin/orexin receptor activation in the posterior hypothalamic area (PH) of the rat on dural nociceptive input. Orexins were microinjected into the PH and the effects on responses of neurones in the caudal trigeminal nucleus studied. Injection of orexin A decreased the A- and C-fibre responses to dural electrical stimulation as well as spontaneous activity. Responses to noxious thermal stimulation of the facial skin were also decreased by orexin A. Injection of orexin B into the PH, however, elicited increased responses to dural stimulation in A- and C-fibre responses and resulted in increased spontaneous activity. Responses to facial thermal stimulation were also increased by orexin B. Control injection of saline into the PH had no significant effect. The results show a differential modulation of dural nociceptive input by orexin A and B receptor activation in the PH. The results support the role of the PH in the nociceptive processing of meningeal input. As both peptides are also involved in hypothalamic regulation of neuroendocrine and autonomic functions, orexinergic mechanisms in the PH may provide a link for endocrine and autonomic changes as well as nociceptive phenomena seen in primary headache disorders.
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Cites
The Rat Brain in Stereotaxic Coordinates
(1982) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 51,963
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · cited 2×
“…named orexin A [hypocretin] and orexin B, which are selectively synthesised in the lateral and posterior hypothalamus, have been described (Date et al., 1999; de Lecea et al., 1998; Marcus et al., 2001; Nambu et al., 1999; Peyron et al., 1998; Sakurai et al., 1998; Trivedi et al., 1998).”
BackgroundNeurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Taussig, M. (2012) · Routledge eBooks · doi:10.4324/9780203397244 · Cited by 2,532
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659
Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation
Reynolds, D. V. (1969) · Science · doi:10.1126/science.164.3878.444 · Cited by 1,389
Orexin A activates locus coeruleus cell firing and increases arousal in the rat
Hagan, J. J., Leslie, R. A., Patel, S., Evans, M. L., Wattam, T. A., Holmes, S., Benham, C. D., Taylor, S. G., Routledge, C., Hemmati, P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10911 · Cited by 1,234
Hypothalamic activation in cluster headache attacks
May, A., Bahra, A., Büchel, C., Frackowiak, R. S., & Goadsby, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02470-2 · Cited by 1,123
Self-citation
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Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998
Self-citationDiencephalic and brainstem mechanisms in migraine
Akerman, S., Holland, P. R., & Goadsby, P. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3057 · Cited by 532
Self-citationModifiable risk factors for migraine progression
Bigal, M. E., & Lipton, R. B. (2006) · Headache: The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2006.00577.x · Cited by 334
The discovery of suvorexant, the first orexin receptor drug for insomnia
Coleman, P. J., Gotter, A. L., Herring, W. J., Winrow, C. J., & Renger, J. J. (2017) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104837 · Cited by 128
Tham, S. W., Palermo, T. M., Vavilala, M. S., Wang, J., Jaffe, K. M., Koepsell, T. D., Dorsch, A., Temkin, N., Durbin, D., & Rivara, F. P. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2011.2126 · Cited by 109
Metadata
- Authors
- Bartsch, T., Levy, M. J., Knight, Y. E., & Goadsby, P. J.
- Venue
- Pain
- Published
- 2004-06
- Volume
- 109
- Issue
- 3
- Pages
- 367-378
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2091319425
- Cited by
- 296
- References
- 57
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
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