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Cited by 226Pain Mechanisms and TreatmentsIon Channels and ReceptorsPain Management and Treatment

The DOI matches its Crossref record; 54 of the 56 references it cites were found in a registry or an index.

Peripheral and central components of habituation of heat pain perception and evoked potentials in humans

Greffrath, Wolfgang, Baumgärtner, Ulf, Treede, Rolf-Detlef·2007·Pain
DOI 10.1016/j.pain.2007.04.026
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Abstract

For the neurophysiological examination of nociceptive pathways, contact-heat evoked potentials (contact-heat EPs) are elicited by repetitive brief noxious heat stimuli. Suppression of heat responses in primary nociceptive neurons during repetitive stimulation has been shown in animal models in vivo and in vitro. We now investigated whether heat pain and contact-heat EPs in humans display equivalent signs of habituation. Heat pain and EPs were elicited in 16 volunteers with a contact thermode (30 degrees Cs(-1)). Heat pulses at three intensities (pain threshold, moderate noxious and maximum available) were applied to the right forearm either by moving the thermode after each pulse to variable locations or when fixed to one location (inter-stimulus intervals 8-10s). Contact-heat EPs consisted of an early negativity in temporal leads (N1), followed by a biphasic response at the vertex (N2-P2). Pain ratings and contact-heat EPs (N1 and N2-P2 components) displayed significant temperature dependence. N2-P2 correlated positively with ratings. With stimulation at variable locations, both measures slowly decreased with time constants tau of 2 min (ratings) and 12 min (EPs). With stimulation at a fixed location, habituation was much faster for both, ratings (tau=10s) and EPs (tau=33 s). As a consequence, both measures were significantly reduced (p<0.005) leading to a rightward shift of the stimulus-response function by 5 degrees C. In conclusion, human heat pain perception and contact-heat EPs display signs of rapid habituation when stimulation is restricted to a fixed location and thus, reflect fatigue of peripheral nociceptive neurons. Habituation within the central nervous system is slower and less pronounced.

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Metadata

Authors
Greffrath, W., Baumgärtner, U., & Treede, R.-D.
Affiliations
Johannes Gutenberg University Mainz (DE)
Corresponding author
Greffrath, Wolfgang
ORCID
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-12
Volume
132
Issue
3
Pages
301-311
ISSN
0304-3959 (ISSN-L)
DOI
10.1016/j.pain.2007.04.026
OpenAlex
W2068862426
Cited by
226
References
56
Citations by year
2026: 2 · 2025: 11 · 2024: 13 · 2023: 9 · 2022: 20 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 16 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 18 · 2012: 17
FWCI
5.56
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
thermal pain, habituation, contact heat evoked potentials, nociception, stimulus-response function, pain threshold, thermode
MeSH terms
Adult, Central Nervous System, Evoked Potentials, Somatosensory, Female, Habituation, Psychophysiologic, Hot Temperature, Humans, Male, Pain, Pain Measurement, Pain Threshold, Peripheral Nervous System

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