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Peripheral and central components of habituation of heat pain perception and evoked potentials in humans

Greffrath, Wolfgang, Baumgärtner, Ulf, Treede, Rolf-Detlef·2007·Pain

DOI 10.1016/j.pain.2007.04.026

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Abstract

For the neurophysiological examination of nociceptive pathways, contact-heat evoked potentials (contact-heat EPs) are elicited by repetitive brief noxious heat stimuli. Suppression of heat responses in primary nociceptive neurons during repetitive stimulation has been shown in animal models in vivo and in vitro. We now investigated whether heat pain and contact-heat EPs in humans display equivalent signs of habituation. Heat pain and EPs were elicited in 16 volunteers with a contact thermode (30 degrees Cs(-1)). Heat pulses at three intensities (pain threshold, moderate noxious and maximum available) were applied to the right forearm either by moving the thermode after each pulse to variable locations or when fixed to one location (inter-stimulus intervals 8-10s). Contact-heat EPs consisted of an early negativity in temporal leads (N1), followed by a biphasic response at the vertex (N2-P2). Pain ratings and contact-heat EPs (N1 and N2-P2 components) displayed significant temperature dependence. N2-P2 correlated positively with ratings. With stimulation at variable locations, both measures slowly decreased with time constants tau of 2 min (ratings) and 12 min (EPs). With stimulation at a fixed location, habituation was much faster for both, ratings (tau=10s) and EPs (tau=33 s). As a consequence, both measures were significantly reduced (p<0.005) leading to a rightward shift of the stimulus-response function by 5 degrees C. In conclusion, human heat pain perception and contact-heat EPs display signs of rapid habituation when stimulation is restricted to a fixed location and thus, reflect fatigue of peripheral nociceptive neurons. Habituation within the central nervous system is slower and less pronounced.

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Authors: Greffrath, W., Baumgärtner, U., & Treede, R.-D.
Affiliations: Johannes Gutenberg University Mainz (DE)
Corresponding author: Greffrath, Wolfgang
ORCID: Greffrath, Wolfgang
Baumgärtner, Ulf
Treede, Rolf-Detlef
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-12
Volume: 132
Issue: 3
Pages: 301-311
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2007.04.026
OpenAlex: W2068862426
Cited by: 226
References: 56
Citations by year: 2026: 2 · 2025: 11 · 2024: 13 · 2023: 9 · 2022: 20 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 16 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 18 · 2012: 17
FWCI: 5.56
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: thermal pain, habituation, contact heat evoked potentials, nociception, stimulus-response function, pain threshold, thermode
MeSH terms: Adult, Central Nervous System, Evoked Potentials, Somatosensory, Female, Habituation, Psychophysiologic, Hot Temperature, Humans, Male, Pain, Pain Measurement, Pain Threshold, Peripheral Nervous System

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Peripheral and central components of habituation of heat pain perception and evoked potentials in humans

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