The DOI matches its Crossref record; 54 of the 56 references it cites were found in a registry or an index.
Peripheral and central components of habituation of heat pain perception and evoked potentials in humans
Abstract
For the neurophysiological examination of nociceptive pathways, contact-heat evoked potentials (contact-heat EPs) are elicited by repetitive brief noxious heat stimuli. Suppression of heat responses in primary nociceptive neurons during repetitive stimulation has been shown in animal models in vivo and in vitro. We now investigated whether heat pain and contact-heat EPs in humans display equivalent signs of habituation. Heat pain and EPs were elicited in 16 volunteers with a contact thermode (30 degrees Cs(-1)). Heat pulses at three intensities (pain threshold, moderate noxious and maximum available) were applied to the right forearm either by moving the thermode after each pulse to variable locations or when fixed to one location (inter-stimulus intervals 8-10s). Contact-heat EPs consisted of an early negativity in temporal leads (N1), followed by a biphasic response at the vertex (N2-P2). Pain ratings and contact-heat EPs (N1 and N2-P2 components) displayed significant temperature dependence. N2-P2 correlated positively with ratings. With stimulation at variable locations, both measures slowly decreased with time constants tau of 2 min (ratings) and 12 min (EPs). With stimulation at a fixed location, habituation was much faster for both, ratings (tau=10s) and EPs (tau=33 s). As a consequence, both measures were significantly reduced (p<0.005) leading to a rightward shift of the stimulus-response function by 5 degrees C. In conclusion, human heat pain perception and contact-heat EPs display signs of rapid habituation when stimulation is restricted to a fixed location and thus, reflect fatigue of peripheral nociceptive neurons. Habituation within the central nervous system is slower and less pronounced.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, it is important to note that responses to a cue could change over the course of the experimental session due to factors such as fatigue, habituation or learning23–28.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [23]
Citations
Cites
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086
Advances in Pain Research and Therapy
Wang, J. K. (1980) · Anesthesia & Analgesia · doi:10.1213/00000539-198002000-00022 · Cited by 2,263
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Keeping pain out of mind: The role of the dorsolateral prefrontal cortex in pain modulation
Lorenz, J., Minoshima, S., & Casey, K. L. (2003) · Brain · doi:10.1093/brain/awg102 · Cited by 952
Peripheral and central mechanisms of cutaneous hyperalgesia
Treede, R., Meyer, R. A., Raja, S. N., & Campbell, J. N. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90027-c · Cited by 917
Self-citationWind-up of spinal cord neurones and pain sensation: much ado about something?
Herrero, J. F., Laird, J. M. A., & Lopez-Garcia, J. A. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00051-9 · Cited by 714
Price, D. D., Hu, J. W., Dubner, R. A., & Gracely, R. H. (1977) · Pain · doi:10.1016/0304-3959(77)90035-5 · Cited by 589
Brain generators of laser-evoked potentials: from dipoles to functional significance
Garcia-Larrea, L., Frot, M., & Valeriani, M. (2003) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/j.neucli.2003.10.008 · Cited by 541
EFNS guidelines on neuropathic pain assessment
Cruccu, G., Anand, P., Attal, N., García-Larrea, L., Haanpää, M. L., Jørum, E., Serra, J., & Jensen, T. S. (2004) · European Journal of Neurology · doi:10.1111/j.1468-1331.2004.00791.x · Cited by 534
LaMotte, R. H., & Campbell, J. N. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.2.509 · Cited by 456
Cited by
Sorted by citations
Thermal sensitivity in the elderly: A review
Guergova, S., & Dufour, A. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.009 · Cited by 258
Depression and changed pain perception: Hints for a central disinhibition mechanism
Klauenberg, S., Maier, C., Assion, H., Hoffmann, A., Krumova, E. K., Magerl, W., Scherens, A., Treede, R., & Juckel, G. (2008) · Pain · doi:10.1016/j.pain.2008.09.003 · Cited by 210
Self-citationCharacterizing and minimizing the contribution of sensory inputs to TMS-evoked potentials
Biabani, M., Fornito, A., Mutanen, T. P., Morrow, J., & Rogasch, N. C. (2019) · Brain Stimulation · doi:10.1016/j.brs.2019.07.009 · Cited by 158
Processing of nociceptive input from posterior to anterior insula in humans
Frot, M., Faillenot, I., & Mauguı̀ere, F. (2014) · Human Brain Mapping · doi:10.1002/hbm.22565 · Cited by 156
Tiede, W., Magerl, W., Baumgärtner, U., Durrer, B., Ehlert, U., & Treede, R.-D. (2010) · Pain · doi:10.1016/j.pain.2009.08.029 · Cited by 153
Self-citation
Metadata
- Authors
- Greffrath, W., Baumgärtner, U., & Treede, R.-D.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Greffrath, Wolfgang
- Venue
- Pain
- Published
- 2007-12
- Volume
- 132
- Issue
- 3
- Pages
- 301-311
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2068862426
- Cited by
- 226
- References
- 56
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 13 · 2023: 9 · 2022: 20 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 16 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 18 · 2012: 17
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- thermal pain, habituation, contact heat evoked potentials, nociception, stimulus-response function, pain threshold, thermode
- MeSH terms
- Adult, Central Nervous System, Evoked Potentials, Somatosensory, Female, Habituation, Psychophysiologic, Hot Temperature, Humans, Male, Pain, Pain Measurement, Pain Threshold, Peripheral Nervous System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
