Cited by 337Musculoskeletal pain and rehabilitationPsychosomatic Disorders and Their TreatmentsMental Health Treatment and Access

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The relation between multiple pains and mental disorders: Results from the World Mental Health Surveys

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Gureje, Oye, Von Korff, Michael, Kola, Lola, Demyttenaere, Koen, He, Yanling, Posada-Villa, José, Lepine, Jean Pierre, Angermeyer, Matthias C., Levinson, Daphna, de Girolamo, Giovanni, Iwata, Noboru, Karam, Aimee, Borges, Guilherme Luiz Guimaraes, de Graaf, Ron, Browne, Mark Oakley, Stein, Dan J., Haro, Josep Maria, Bromet, Evelyn J., Kessler, Ron C., Alonso, Jordi·2008·Pain

DOI 10.1016/j.pain.2007.05.005

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Abstract

It is unclear whether differences exist in the prevalence of mood, anxiety and alcohol use disorders among persons with multiple pain conditions compared with those with single pain problems. We conducted population surveys in 17 countries in Europe, the Americas, the Middle East, Africa, Asia, and the South Pacific. Participants were community-dwelling adults (N=85,088). Mental disorders were assessed with the Composite International Diagnostic Interview. Pain was assessed by self-report. Both multiple and single site pain problems were associated with mood and anxiety disorders, but not with alcohol abuse or dependence. In general, the prevalence of specific mood and anxiety disorders followed a linear pattern with the lowest rates found among persons with no pain, intermediate rates among those with one pain, and highest rates among those with multi-site pain problems. Relative to persons not reporting pain, the pooled estimates of the age-sex adjusted odds ratios were 1.8 (1.7-2.0) for mood disorders and 1.9 (1.8-2.1) for anxiety disorders for persons with single site pain; 3.7 (3.3-4.1) for mood disorders and 3.6 (3.3-4.0) for anxiety disorders among those with multi-site pain. Our results indicate that the presence of multiple pain conditions was strongly and comparably associated with mood and anxiety disorders in diverse cultures. This consistent pattern of associations suggests that diffuse pain and psychiatric disorders are generally associated, rather than diffuse pain representing an idiom for expressing distress that is specific to particular cultural settings or diffuse pain solely representing a form of masked depression.

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Authors: Gureje, O., Von Korff, M., Kola, L., Demyttenaere, K., He, Y., Posada-Villa, J., Lepine, J. P., Angermeyer, M. C., Levinson, D., de Girolamo, G., Iwata, N., Karam, A., Borges, G. L. G., de Graaf, R., Browne, M. O., Stein, D. J., Haro, J. M., Bromet, E. J., Kessler, R. C., & Alonso, J.
Affiliations: University of Ibadan (NG)
University College Hospital, Ibadan (NG)
Shanghai Mental Health Center (CN)
Hôpital Fernand-Widal (FR)
Leipzig University (DE)
Israel Ministry of Health (IL)
Hiroshima International University (JP)
Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
University of Cape Town (ZA)
Stony Brook University (US)
Municipal Institute for Medical Research (ES)
Corresponding author: Gureje, Oye
ORCID: Gureje, Oye
Kola, Lola
Demyttenaere, Koen
He, Yanling
Iwata, Noboru
Borges, Guilherme Luiz Guimaraes
Stein, Dan J.
Haro, Josep Maria
Bromet, Evelyn J.
Alonso, Jordi
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-03
Volume: 135
Issue: 1
Pages: 82-91
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2007.05.005
OpenAlex: W2030283753
Cited by: 337
References: 42
Citations by year: 2026: 7 · 2025: 12 · 2024: 19 · 2023: 22 · 2022: 17 · 2021: 20 · 2020: 8 · 2019: 21 · 2018: 21 · 2017: 23 · 2016: 23 · 2015: 15 · 2014: 22 · 2013: 20 · 2012: 14
FWCI: 12.92
Type: journal article
Language: en
Open access: green
lirias.kuleuven.be
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Lirias (KU Leuven) (submittedVersion, other-oa)
Funders: John D. and Catherine T. MacArthur Foundation (R01 DA016558, R13-MH066849)
Bristol-Myers Squibb
Eli Lilly and Company
Pfizer
World Health Organization
Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05)
Pfizer Foundation (R01‐MH069864, R01-DA016558, R13-MH066849)
Pan American Health Organization
National Institute of Mental Health (R13-MH-066849, R0 1-MH61905, R01‐MH070884, U01-MH-60220, R01MH061905, R01MH059575, U01MH060220, R01‐MH069864)
National Institute on Drug Abuse (R01DA016558)
Fogarty International Center (FIRCA R01-TW006481, R01-TW006481)
Topics: Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: chronic pain, mood disorders, anxiety disorders, alcoholism, mental illness, prevalence, diffuse pain, masked depression, cross-cultural comparison, community-dwelling adults
MeSH terms: Adult, Mental Disorders, Cross-Sectional Studies, Data Collection, Female, Health Surveys, Humans, Male, Middle Aged, Pain, Global Health, Prevalence, Sickness Impact Profile, Internationality

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The relation between multiple pains and mental disorders: Results from the World Mental Health Surveys

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