Placebo analgesia: Psychological and neurobiological mechanisms
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aNational Center for Complementary and Alternative Medicine (NCCAM), National Institute of Mental Health (NIMH) and Clinical Center, Department of Bioethics, National Institutes of Health (NIH), Bethesda, MD, USA bOutpatient Clinic of Behavior Therapy, Department of Psychology, University of Hamburg, Hamburg, Germany cDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany dNeuroImage Nord, Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany *Corresponding author. Address: National Center for Complementary and Alternative Medicine, National Institute of Mental Health and the Clinical Center, Department of Bioethics, Building 10, Room 1C154, Bethesda, MD 20892-1156, USA. Tel.: +1 301 435 8715; fax: +1 301 496 0760. E-mail address:[email protected] Article history: Received 14 January 2013; Accepted 4 February 2013.
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Expectations could modulate reinforcement signals, and if such manipulations affect the reinforcement signal used in calculating prediction errors, it would short-circuit learning by suppressing cue-inconsistent prediction errors.
“If these manipulations affect the reinforcement signal used in calculating prediction errors, it would short-circuit learning by suppressing cue-inconsistent prediction errors.”
From Social information creates self-fulfilling prophecies in judgments of pain, vicarious pain, and cognitive effort (2026) · cites this paper as [40]
The Psychological aspects of placebo analgesia section describes expectations and conditioning, including pairing a placebo with reduced pain to strengthen later analgesic expectations. It does not address reinforcement signals used to calculate prediction errors or the suppression of cue-inconsistent errors that the citing sentence proposes (searched for prediction errors and reinforcement signals). No page number is available in our copy. (LLM, conf=0.75)
Experimental — accuracy not yet measuredNocebo effects can influence pain pathways by triggering physiological changes that affect pain perception, pharmacological efficacy, and clinical outcomes in pain management.
“have the potential to significantly influence pain pathways by triggering physiological changes that could consequently affect not only pain perception but also pharmacological efficacy and clinical outcomes in the context of pain management.28”
From Nocebo and pain: an overview of the psychoneurobiological mechanisms (2017) · cites this paper as [28]
Nocebo effects can be induced in different ways: with negative expectations, associative learning, partial conditioning, social learning and even without conscious awareness and direct learning.
“nocebo effects can be induced in different ways: with negative expectations891011, associative learning121314, partial conditioning15, social learning1617 and even without conscious awareness and direct learning18.”
From Changes in perception of treatment efficacy are associated to the magnitude of the nocebo effect and to personality traits (2016) · cites this paper as [7]
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- Authors
- Colloca, L., Klinger, R., Flor, H., & Bingel, U.
- Affiliations
- National Institutes of Health (US)
- Universität Hamburg (DE)
- Heidelberg University (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Colloca, Luana
- Venue
- Pain
- Published
- 2013-04
- Volume
- 154
- Issue
- 4
- Pages
- 511-514
- ISSN
- 0304-3959 (ISSN-L)
- PMC
- PMC3626115
- OpenAlex
- W1968059543
- Cited by
- 263
- References
- 33
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 18 · 2023: 13 · 2022: 22 · 2021: 16 · 2020: 16 · 2019: 22 · 2018: 26 · 2017: 20 · 2016: 18 · 2015: 22 · 2014: 29 · 2013: 12 · 2012: 1
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Funders
- National Institutes of Health (Z99‐AA999999, Z99 AT999999, Z99 DA999999)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- placebo analgesia, placebo effect, psychological mechanisms, neurobiological mechanisms, pain perception, expectations
- MeSH terms
- Analgesia, Brain, Humans, Neurobiology, Pain, Placebo Effect, Pain Management
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