Cited by 101Pain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

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Neurohormonal effects of oxytocin and vasopressin receptor agonists on spinal pain processing in male rats

Juif, Pierre-Eric, Poisbeau, Pierrick·2013·Pain

DOI 10.1016/j.pain.2013.05.003

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Abstract

Oxytocin (OT) and arginine vasopressin (AVP) are 2 neuropeptides that display well-known effects on the reproductive system. Although still controversial, oxytocin and vasopressin were demonstrated to exert potent effects on the nociceptive system when administered directly in various central nervous structures. On the other hand, little is known about their peripheral (hormonal) actions on nociception and pain responses. The aim of the present work was to characterize the effects of physiological blood concentrations of OT and AVP on spinal nociception and on pain responses. To do so, growing doses of OT or AVP were administered intravenously and the nociceptive processing by spinal cord neurons was analyzed in anesthetized male rats in vivo. We observed that the action potentials mediated by C-type nociceptive fibers was strongly reduced (antinociception) after intravenous injections of low doses of OT (<5 μg) or AVP (<500 pg), whereas an increase (pronociception) was observed at higher doses. Interestingly, antinociceptive and pronociceptive effects were fully abolished in the presence of the OT receptor antagonist and the AVP receptor antagonist type 1A (V1A), respectively. We confirmed this result with a behavioral model of forced swim stress-induced analgesia associated with plasmatic release of OT (and not vasopressin). Stress-induced analgesia was transiently lost after i.v. administration of OTR antagonist. Together, the present work provides straightforward evidence that blood levels of OT and AVP modulate nociception, windup plasticity and pain responses. The final target structures explaining these effects remains to be identified but are likely to be C-type nociceptors.

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Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
Swanson, L. W., & Sawchenko, P. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001413 · Cited by 1,991
The paraventricular nucleus of the hypothalamus: Cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double‐labeling methods
Swanson, L. W., & Kuypers, H. G. J. M. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901940306 · Cited by 1,413
Morphology of vasopressin and oxytocin neurones and their central and vascular projections
Sofroniew, M. V. (1983) · Progress in Brain Research · doi:10.1016/s0079-6123(08)64378-2 · Cited by 370
Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons
Wotjak, C. T., Ganster, J., Kohl, G., Holsboer, F., Landgraf, R., & Engelmann, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00683-0 · Cited by 345
Hypothalamic enkephalin neurones may regulate the neurohypophysis
Rossier, J., Battenberg, E., Pittman, Q. J., Bayón, A., Koda, L. Y., MILLER, R., Guillemin, R., & Bloom, F. E. (1979) · Nature · doi:10.1038/277653a0 · Cited by 259
Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids
Leuner, B., Caponiti, J., & Gould, E. (2011) · Hippocampus · doi:10.1002/hipo.20947 · Cited by 237
Appearance and transient expression of oxytocin receptors in fetal, infant, and peripubertal rat brain studied by autoradiography and electrophysiology
Tribollet, E., Charpak, S., Schmidt, A., Dubois-Dauphin, M., & Dreifuss, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01764.1989 · Cited by 228
Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse
Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189

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Authors: Juif, P.-E., & Poisbeau, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Poisbeau, Pierrick
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-08
Volume: 154
Issue: 8
Pages: 1449-1456
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2013.05.003
OpenAlex: W2155592901
Cited by: 101
References: 61
Citations by year: 2026: 5 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 13 · 2016: 7 · 2015: 4 · 2014: 11 · 2013: 3
FWCI: 5.79
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Centre National de la Recherche Scientifique
Institut Universitaire de France
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: oxytocin, vasopressin, spinal nociception, antinociception, pronociception, stress-induced analgesia, oxytocin receptor antagonist
MeSH terms: Action Potentials, Analgesics, Animals, Arginine Vasopressin, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Interactions, Hyperalgesia, Male, Neurons, Oxytocin, Pain, Spinal Cord, Swimming, Rats, Sprague-Dawley, Pain Threshold, Receptors, Vasopressin, Nerve Fibers, Unmyelinated, Rats

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Neurohormonal effects of oxytocin and vasopressin receptor agonists on spinal pain processing in male rats

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