Cited by 101Pain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

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Neurohormonal effects of oxytocin and vasopressin receptor agonists on spinal pain processing in male rats

Juif, Pierre-Eric, Poisbeau, Pierrick·2013·Pain

DOI 10.1016/j.pain.2013.05.003

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Abstract

Oxytocin (OT) and arginine vasopressin (AVP) are 2 neuropeptides that display well-known effects on the reproductive system. Although still controversial, oxytocin and vasopressin were demonstrated to exert potent effects on the nociceptive system when administered directly in various central nervous structures. On the other hand, little is known about their peripheral (hormonal) actions on nociception and pain responses. The aim of the present work was to characterize the effects of physiological blood concentrations of OT and AVP on spinal nociception and on pain responses. To do so, growing doses of OT or AVP were administered intravenously and the nociceptive processing by spinal cord neurons was analyzed in anesthetized male rats in vivo. We observed that the action potentials mediated by C-type nociceptive fibers was strongly reduced (antinociception) after intravenous injections of low doses of OT (<5 μg) or AVP (<500 pg), whereas an increase (pronociception) was observed at higher doses. Interestingly, antinociceptive and pronociceptive effects were fully abolished in the presence of the OT receptor antagonist and the AVP receptor antagonist type 1A (V1A), respectively. We confirmed this result with a behavioral model of forced swim stress-induced analgesia associated with plasmatic release of OT (and not vasopressin). Stress-induced analgesia was transiently lost after i.v. administration of OTR antagonist. Together, the present work provides straightforward evidence that blood levels of OT and AVP modulate nociception, windup plasticity and pain responses. The final target structures explaining these effects remains to be identified but are likely to be C-type nociceptors.

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Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
Swanson, L. W., & Sawchenko, P. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001413 · Cited by 1,991
The paraventricular nucleus of the hypothalamus: Cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double‐labeling methods
Swanson, L. W., & Kuypers, H. G. J. M. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901940306 · Cited by 1,413
Morphology of vasopressin and oxytocin neurones and their central and vascular projections
Sofroniew, M. V. (1983) · Progress in Brain Research · doi:10.1016/s0079-6123(08)64378-2 · Cited by 370
Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons
Wotjak, C. T., Ganster, J., Kohl, G., Holsboer, F., Landgraf, R., & Engelmann, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00683-0 · Cited by 345
Hypothalamic enkephalin neurones may regulate the neurohypophysis
Rossier, J., Battenberg, E., Pittman, Q. J., Bayón, A., Koda, L. Y., MILLER, R., Guillemin, R., & Bloom, F. E. (1979) · Nature · doi:10.1038/277653a0 · Cited by 259
Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids
Leuner, B., Caponiti, J., & Gould, E. (2011) · Hippocampus · doi:10.1002/hipo.20947 · Cited by 237
Appearance and transient expression of oxytocin receptors in fetal, infant, and peripubertal rat brain studied by autoradiography and electrophysiology
Tribollet, E., Charpak, S., Schmidt, A., Dubois-Dauphin, M., & Dreifuss, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01764.1989 · Cited by 228
Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse
Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189
Blood—Brain Barrier and Peptides
Ermisch, A., Rühle, H., Landgraf, R., & Hess, J. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.49 · Cited by 187
Oxytocin-Induced Antinociception in the Spinal Cord is Mediated by a Subpopulation of Glutamatergic Neurons in Lamina I-II Which Amplify GABAergic Inhibition
Breton, J.-D., Veinante, P., Uhl-Bronner, S., Vergnano, A. M., Freund-Mercier, M. J., Schlichter, R., & Poisbeau, P. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-19 · Cited by 152
Self-citation
Oxytocin mediates stress‐induced analgesia in adult mice
Robinson, D. A., Wei, F., Wang, G. D., Li, P., Kim, S. J., Vogt, S. K., Muglia, L. J., & Zhuo, M. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013492 · Cited by 148
Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat
Véronneau-Longueville, F., Rampin, O., Freund‐Mercier, M. J., Tang, Y., Calas, A., Marson, L., McKenna, K. E., Stoeckel, M. E., Benoît, G., & Giuliano, F. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00262-6 · Cited by 140
Anti-nociceptive effects of oxytocin in rats and mice
Lundeberg, T., Uvnäs‐Moberg, K., Ågren, G., & BRUZELIUS, G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90262-3 · Cited by 139
Oxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonist
Miranda-Cardenas, Y., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., Rodríguez-Jiménez, J., López-Hidalgo, M. A., Freund‐Mercier, M. J., & Condés‐Lara, M. (2006) · Pain · doi:10.1016/j.pain.2006.01.029 · Cited by 131
Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges
Chini, B., & Manning, M. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350737 · Cited by 123
Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction
Mogil, J. S., Sorge, R. E., LaCroix‐Fralish, M. L., Smith, S. B., Fortin, A., Sotocinal, S. G., Ritchie, J., Austin, J., Schorscher-Petcu, A., Melmed, K. R., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2941 · Cited by 115
Central oxytocin enhances antinociception in the rat
Yang, J., Yang, Y., Chen, J.-M., Liu, W., Wang, C., & Lin, B.-C. (2007) · Peptides · doi:10.1016/j.peptides.2007.03.003 · Cited by 102
Intraventricular Somatostatin-14, Arginine Vasopressin, and Oxytocin: Analgesic Effect in a Patient with Intractable Cancer Pain
Madrazo, I., Franco-Bourland, R. E., León-Meza, V. M., & Mena, I. X. (1987) · Stereotactic and Functional Neurosurgery · doi:10.1159/000100753 · Cited by 98
Involvement of oxytocin in spinal antinociception in rats with inflammation
Yu, S.-Q., Lundeberg, T., & Yu, L. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03019-1 · Cited by 98
In vivo single unit extracellular recordings from spinal cord neurones of rats
Urch, C., & Dickenson, A. H. (2003) · Brain Research Protocols · doi:10.1016/s1385-299x(03)00068-0 · Cited by 89
Evaluation of cardiac output, total peripheral vascular resistance, and plasma concentrations of vasopressin in the conscious, unrestrained rat during endotoxemia.
Brackett, D. J., Schaefer, C., Tompkins, P., Fagraeus, L., Peters, L. J., & Wilson, M. F. (1985) · PubMed · Cited by 88
Pattern of Oxytocin Concentrations in the Plasma and Cerebrospinal Fluid of Lactating Rhesus Monkeys (Macaca mulatto,): Evidence for Functionally Independent Oxytocinergic Pathways in Primates*
AMICO, J. A., CHALLINOR, S. M., & CAMERON, J. L. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1531 · Cited by 87
Localization of Oxytocin Binding Sites in the Thoracic and Upper Lumbar Spinal Cord of the Adult and Postnatal Rat: A Histoautoradiographic Study
Reiter, M. K., Krémarik, P., Freund‐Mercier, M. J., Stoeckel, M. E., Desaulles, E., & FELTZ, P. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00251.x · Cited by 85
PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats
Martı́nez-Lorenzana, G., Espinosa-López, L., Carranza, M., Arámburo, C., Paz, C., Rojas‐Piloni, G., & Condés‐Lara, M. (2008) · Pain · doi:10.1016/j.pain.2008.08.015 · Cited by 84
A radioiodinated linear vasopressin antagonist: A ligand with high affinity and specificity for V1a receptors
Schmidt, A., Audigier, S., Barberis, C., Jard, S., Manning, M., Kołodziejczyk, A. S., & Sawyer, W. H. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80448-c · Cited by 83
Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons
Moreno-López, Y., Martı́nez-Lorenzana, G., Condés‐Lara, M., & Rojas‐Piloni, G. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.09.008 · Cited by 80
Blockade effect of mu and kappa opioid antagonists on the anti-nociception induced by intra-periaqueductal grey injection of oxytocin in rats
Ge, Y., Lundeberg, T., & Yu, L.-C. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03346-7 · Cited by 79
Distribution of vasopressin and oxytocin receptors in the rat spinal cord: sex-related differences and effect of castration in pudendal motor nuclei
Tribollet, E., Barberis, C., & Arsenijévic, Y. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00591-x · Cited by 76
Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats
Condés‐Lara, M., Maie, I. A. S., & Dickenson, A. H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.020 · Cited by 71
Neurohypophysial Peptides in Cerebrospinal Fluid
Robinson, I. C. A. F. (1983) · Progress in brain research · doi:10.1016/s0079-6123(08)64381-2 · Cited by 63
Brain uptake and the analgesic effect of oxytocin—its usefulness as an analgesic agent
Kang, Y.-S., & Park, J.-H. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02975453 · Cited by 63
Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats
Gao, L., & Yu, L. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.02.011 · Cited by 61
Angiotensin-converting enzyme in discrete forebrain areas of spontaneously hypertensive rats
Chevillard, C., Niwa, M., & Saavedra, J. M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90611-5 · Cited by 58
Actions of oxytocin and interactions with glutamate on spontaneous and evoked dorsal spinal cord neuronal activities
Condés‐Lara, M., Marina, N., Martı́nez-Lorenzana, G., Luis‐Delgado, O. E., & Freund‐Mercier, M. J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02690-8 · Cited by 58
Oxytocin is expressed in epidermal keratinocytes and released upon stimulation with adenosine 5′‐[γ‐thio]triphosphate in vitro
Denda, S., Takei, K., Kumamoto, J., Goto, M., Tsutsumi, M., & Denda, M. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01507.x · Cited by 53
Vasopressin and oxytocin in the rat spinal cord: analysis of their role in the control of nociception
Millan, M. J., Schmauss, C., Millan, M. H., & Herz, A. (1984) · Brain Research · doi:10.1016/0006-8993(84)90610-3 · Cited by 53
Central antinociceptive effects of lysine-vasopressin and an analogue
Kordower, J. H., Sikorszky, V., & Bodnar, R. J. (1982) · Peptides · doi:10.1016/0196-9781(82)90159-0 · Cited by 51
Role of spinal cord neuropeptides in pain sensitivity and analgesia: Thyrotropin releasing hormone and vasopressin
Watkins, L. R., Suberg, S. N., Thurston, C. L., & Culhane, E. S. (1986) · Brain Research · doi:10.1016/0006-8993(86)90455-5 · Cited by 46
Oxytocin levels in the plasma and cerebrospinal fluid of male rats: effects of circadian phase, light and stress
Devarajan, K., & Rusak, B. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.112 · Cited by 44
Oxytocin, but not vassopressin, modulates nociceptive responses in dorsal horn neurons
Rojas‐Piloni, G., Mejía-Rodríguez, R., Martı́nez-Lorenzana, G., & Condés‐Lara, M. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.076 · Cited by 43
Antinociceptive role of oxytocin in the nucleus raphe magnus of rats, an involvement of μ-opioid receptor
Wang, J., Lundeberg, T., & Yu, L. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00152-6 · Cited by 42
Paraventricular hypothalamic oxytocinergic cells responding to noxious stimulation and projecting to the spinal dorsal horn represent a homeostatic analgesic mechanism
Condés‐Lara, M., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., & Rodríguez‐Jiménez, J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06899.x · Cited by 41
Role of κ- and δ-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice
Reeta, K. H., Mediratta, P. K., Rathi, N., Jain, H., Chugh, C., & Sharma, K. K. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.04.004 · Cited by 38
Presence of functional vasopressin receptors in spinal ventral horn neurons of young rats: a morphological and electrophysiological study
Liu, X., Tribollet, E., Ogier, R., Barberis, C., & Raggenbass, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02625.x · Cited by 38
Antinociception vs motor effects of intrathecal vasopressin as measured by four pain tests
Thurston, C. L., Culhane, E. S., Suberg, S. N., Carstens, E. E., & Watkins, L. R. (1988) · Brain Research · doi:10.1016/0006-8993(88)90520-3 · Cited by 37
Centrally administered adrenomedullin 2 activates hypothalamic oxytocin-secreting neurons, causing elevated plasma oxytocin level in rats
Hashimoto, H., Hyodo, S., Kawasaki, M., Mera, T., Chen, L., Soya, A., Saito, T., Fujihara, H., Higuchi, T., Takei, Y., et al. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00042.2005 · Cited by 37
Molecular Aspects of Vasopressin Receptor Function
Schöneberg, T., Kostenis, E., Liu, J., Gudermann, T. W., & Wess, J. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_44 · Cited by 37
Endogenous vasopressin increases acute endotoxin shock-provoked gastrointestinal mucosal injury in the rat
Varga, C., Pavo, I. J., Lamarque, D., Szepes, Z., Kiss, J. G., Karácsony, G., László, F. A., & László, F. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00345-8 · Cited by 36
New Topics in Vasopressin Receptors and Approach to Novel Drugs: Vasopressin and Pain Perception
Koshimizu, T., & Tsujimoto, G. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08r18fm · Cited by 36
Arginine vasopressin in periaqueductal gray, which relates to antinociception, comes from hypothalamic paraventricular nucleus in the rat
Yang, J., Yang, Y., Chen, J.-M., Xu, H., Liu, W., & Lin, B.-C. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.10.049 · Cited by 33
Characterization of intrathecal vasopressin-induced antinociception, scratching behavior, and motor suppression
Thurston, C. L., Campbell, I. G., Culhane, E. S., Carstens, E. E., & Watkins, L. R. (1992) · Peptides · doi:10.1016/0196-9781(92)90135-p · Cited by 32
MODULATION OF NOCICEPTIVE THRESHOLDS BY VASOPRESSIN IN THE BRATTLEBORO AND NORMAL RAT*
Bodnar, R. J., Wallace, M. M., Kordower, J. H., Nilaver, G., Cort, J. H., & Zimmerman, E. A. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb37491.x · Cited by 30
Specific expression of an oxytocin-enhanced cyan fluorescent protein fusion transgene in the rat hypothalamus and posterior pituitary
Katoh, A., Fujihara, H., Ohbuchi, T., Onaka, T., Young, W. S., Dayanithi, G., Yamasaki, Y., Kawata, M., Suzuki, H., Otsubo, H., et al. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0289 · Cited by 23
Isotonic and hypertonic saline act as stressful stimuli for oxytocinergic system of the pituitary, hypothalamus and spinal cord
Lukic, D., & Haldar, J. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90715-f · Cited by 17
Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the caudate nucleus to participate in pain modulation
Yang, J., Li, P., Zhang, X.-Y., Zhang, J., Hao, F., Pan, Y.-J., Lu, G., Lu, L., Wang, D., Wang, G., et al. (2010) · Peptides · doi:10.1016/j.peptides.2010.10.014 · Cited by 11
Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the nucleus raphe magnus to participate in pain modulation
Yang, J., Yuan, H., Liu, W., Song, C.-Y., Xu, H., Wang, G., Song, C., Ni, N., Yang, D., & Lin, B.-C. (2009) · Peptides · doi:10.1016/j.peptides.2009.05.026 · Cited by 11
[Modulation of GABA-activated currents by oxytocin in rat dorsal root ganglion neurons].
Zj, T., Jb, W., Zw, L., Shao, M., Qs, H., & Bw, P. (2000) · PubMed · Cited by 7
Pharmacological characterization of linear analogues of vasopressin generated by the systematic substitution of positions 1 and 6 by l-amino acids
Howl, J., Filer, A. D., Parslow, R. A., Kirk, C. J., Jurzak, M., Smith, A. I., & Wheatley, M. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90523-1 · Cited by 4

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Authors: Juif, P.-E., & Poisbeau, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Poisbeau, Pierrick
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-08
Volume: 154
Issue: 8
Pages: 1449-1456
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2013.05.003
OpenAlex: W2155592901
Cited by: 101
References: 61
Citations by year: 2026: 5 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 13 · 2016: 7 · 2015: 4 · 2014: 11 · 2013: 3
FWCI: 5.79
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Centre National de la Recherche Scientifique
Institut Universitaire de France
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: oxytocin, vasopressin, spinal nociception, antinociception, pronociception, stress-induced analgesia, oxytocin receptor antagonist
MeSH terms: Action Potentials, Analgesics, Animals, Arginine Vasopressin, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Interactions, Hyperalgesia, Male, Neurons, Oxytocin, Pain, Spinal Cord, Swimming, Rats, Sprague-Dawley, Pain Threshold, Receptors, Vasopressin, Nerve Fibers, Unmyelinated, Rats

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Neurohormonal effects of oxytocin and vasopressin receptor agonists on spinal pain processing in male rats

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