Body weight reduction and metformin: Roles in polycystic ovary syndrome

AL-Nozha, Omar; Habib, Fawziah; Mojaddidi, Moaz; El-Bab, Mohamed Fath

doi:10.1016/j.pathophys.2013.03.002

Cited by 20Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsEndometriosis Research and Treatment

Body weight reduction and metformin: Roles in polycystic ovary syndrome

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AL-Nozha, Omar, Habib, Fawziah, Mojaddidi, Moaz, El-Bab, Mohamed Fath·2013·Pathophysiology

DOI 10.1016/j.pathophys.2013.03.002

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Abstract

BACKGROUND AND OBJECTIVES: Polycystic ovary syndrome (PCOS) is a common problem in women at fertile age. A prospective study was conducted to clarify the pathophysiological responses during an application of insulin sensitizer, metformin and weight reduction therapy at the Gynecology Center in Ohud hospital, in AL-Madinah AL-Munawarah, Kingdom of Saudi Arabia. METHODOLOGY: Twenty healthy women served as controls and 180 PCOS women divided into three groups participated in the study. First group was treated with Clomid citrate 100mg/day from the 2nd day of menses to the 6th day plus gonadotrophin from day three to the 13th. Group II was treated as group I plus 850mg metformin twice a day and group III was treated as group I plus weight reduction. Clinical symptoms, menstrual pattern, hirsutism, blood glucose, body mass index, waist-to-hip ratio, insulin, hormonal, and lipid profiles were assessed pre- and post treatment. Insulin resistance was calculated. RESULTS: PCOS women had significantly higher values than the healthy women in most of the measurements. Metformin and weight reduction therapy resulted in a significant decrease in the fasting insulin, glucose/insulin ratio and HOMA-IR. Metformin and weight reduction therapy resulted in a significant decrease in the lipid parameters, testosterone, LH/FSH ratio, SHBG, and prolactin levels. HOMA-IR was significantly higher in women with PCOS. HOMA-IR was positively correlated with testosterone, estradiol, TG, total cholesterol and LDL-cholesterol parameters, and negatively correlated with HDL-cholesterol and FSH levels. CONCLUSION: Metformin therapy and weight reduction had favorable influences on the basic metabolic and hormonal profiles in women with PCOS and that metformin and lifestyle modification (weight reduction via diet restriction or exercise) resulted in a significantly greater weight loss than hormonal therapy alone. Metformin and weight reduction therapy decreased also hyperandrogenism and insulin resistance.

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Metformin's effect on weight in women with PCOS is not as well defined and depends on the population and study design.
“Metformin’s effect on weight in women with PCOS is not as well defined, depending on the population and study design (69–74).”
From GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin (2020) · cites this paper as [73]

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Authors: AL-Nozha, O., Habib, F., Mojaddidi, M., & El-Bab, M. F.
Affiliations: Taibah University (SA)
ORCID: Mojaddidi, Moaz
Venue: Pathophysiology
Publisher: Elsevier BV
Published: 2013-04
Volume: 20
Issue: 2
Pages: 131-137
ISSN: 0928-4680 (ISSN-L)
DOI: 10.1016/j.pathophys.2013.03.002
OpenAlex: W2073881209
Cited by: 20
References: 49
Citations by year: 2024: 3 · 2023: 1 · 2022: 1 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1
FWCI: 2.81
Type: journal article
Language: en
Open access: gold
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pathophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords: polycystic ovary syndrome, metformin, weight loss, insulin resistance, HOMA-IR, hyperandrogenism, testosterone, insulin sensitizers, lifestyle modification, gonadotropin therapy, lipid profile, menstrual pattern, hirsutism

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Body weight reduction and metformin: Roles in polycystic ovary syndrome

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